Association of Toll-Like Receptor Signaling and  Reactive Oxygen Species: A Potential Therapeutic Target for  Posttrauma Acute Lung Injury

<table>Model of HS-induced PMN NADPH oxidase activation. HMGB1 acts through TLR4 and MyD88-dependent signaling to mediate HS-induced NADPH oxidase activation. Akt and P38 MAP kinase are both involved in this event.</table>

Mediators of Inflammation

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Figure 3

Figure 3: Association of Toll-Like Receptor Signaling and  Reactive Oxygen Species: A Potential Therapeutic Target for  Posttrauma Acute Lung Injury 