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Mediators of Inflammation
Volume 2010, Article ID 928030, 5 pages
Review Article

Cytokines and Other Mediators in Alopecia Areata

Andreas Sygros Hospital, University of Athens Medical School, 5 Ionos Dragoumi Street, 16121 Athens, Greece

Received 28 November 2009; Revised 28 January 2010; Accepted 28 January 2010

Academic Editor: Fulvio D'Acquisto

Copyright © 2010 Stamatis Gregoriou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN- 𝛾 , interleukins, TNF- 𝛼 , are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. Among them, MIG, IP-10, BAFF, HLA antigens, MIG, as well as stress hormones are implicated in disease onset and activity. Within the scope of this paper, the authors attempt to shed light upon the complexity of alopecia areata underlying mechanisms and indicate pathways that may suggest future treatments.