Figure 1: The sera of mice in each group were collected before treatment (0), 2, 4, and 8 weeks later, and levels of IgM anti-ssDNA and Antihistone antibodies were detected by ELISA. EI was calculated according to the formula. (a) the level of IgM anti-ssDNA antibody in each group, (b) the level of IgM Antihistone antibody in each group. Data were given in mean±SD (n=68). P*<.05, P**<.01 versus sera at 0 wk, P<.05,P<.01 versus sera in model control mice.