Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice

Figure 1

The sera of mice in each group were collected before treatment (0), 2, 4, and 8 weeks later, and levels of IgM anti-ssDNA and Antihistone antibodies were detected by ELISA. EI was calculated according to the formula. (a) the level of IgM anti-ssDNA antibody in each group, (b) the level of IgM Antihistone antibody in each group. Data were given in $\text{mean}\pm \text{SD}$ ($n=6\text{–}8$). ${}_{}{}^{*}P<.05\text{,}$${}_{}{}^{**}P<.01$ versus sera at 0 wk, $∆P<.05,$$∆∆P<.01$ versus sera in model control mice.

(a)

(b)