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Mediators of Inflammation
Volume 2010, Article ID 976024, 12 pages
http://dx.doi.org/10.1155/2010/976024
Review Article

Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract

Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita 879-5593, Japan

Received 17 November 2009; Revised 10 January 2010; Accepted 15 February 2010

Academic Editor: Kathy Triantafilou

Copyright © 2010 Kaei Nasu and Hisashi Narahara. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [73 citations]

The following is the list of published articles that have cited the current article.

  • Gustavo F. Doncel, and Meredith R. Clark, “Preclinical evaluation of anti-HIV microbicide products: New models and biomarkers,” Antiviral Research, vol. 88, pp. S10–S18, 2010. View at Publisher · View at Google Scholar
  • Claire Gillaux, Celine Mehats, Daniel Vaiman, Dominique Cabrol, and Michelle Breuiller-Fouche, “Functional Screening of TLRs in Human Amniotic Epithelial Cells,” Journal of Immunology, vol. 187, no. 5, pp. 2766–2774, 2011. View at Publisher · View at Google Scholar
  • J. P. Mackern Oberti, M. L. Breser, N. Nunez, M. Maccioni, N. Rodriguez, N. Wantia, T. Ertl, T. Miethke, and V. E. Rivero, “Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45- cells,” Reproduction, vol. 142, no. 3, pp. 427–437, 2011. View at Publisher · View at Google Scholar
  • Sang-Min Lee, Eun-Ju Kim, Kyoungho Suk, and Won-Ha Lee, “CD300F Blocks Both MyD88 and TRIF-Mediated TLR Signaling through Activation of Src Homology Region 2 Domain-Containing Phosphatase 1,” Journal Of Immunology, vol. 186, no. 11, pp. 6296–6303, 2011. View at Publisher · View at Google Scholar
  • Yoshihiko Yamada, Hiroshi Shigetomi, Akira Onogi, Shoji Haruta, Ryuji Kawaguchi, Shozo Yoshida, Naoto Furukawa, Akira Nagai, Yasuhito Tanase, Taihei Tsunemi, Hidekazu Oi, and Hiroshi Kobayashi, “New insights into pattern recognition receptors and their ligands in gynecologic pathologies,” Human Immunology, vol. 72, no. 3, pp. 213–218, 2011. View at Publisher · View at Google Scholar
  • Iara M. Linhares, Paul R. Summers, Bryan Larsen, Paulo C. Giraldo, and Steven S. Witkin, “Contemporary perspectives on vaginal pH and lactobacilli,” American Journal of Obstetrics and Gynecology, vol. 204, no. 2, pp. 120.e1–120.e5, 2011. View at Publisher · View at Google Scholar
  • Jae-Kwan Kim, Sang-Min Lee, Kyoungho Suk, and Won-Ha Lee, “A Novel Pathway Responsible for Lipopolysaccharide-Induced Translational Regulation of TNF-alpha and IL-6 Expression Involves Protein Kinase C and Fascin,” Journal Of Immunology, vol. 187, no. 12, pp. 6327–6334, 2011. View at Publisher · View at Google Scholar
  • Sirivaidyapong, and Chotimanukul, “Differential expression of Toll-like receptor 4 (TLR4) in healthy and infected canine endometrium,” Theriogenology, vol. 76, no. 6, pp. 1152–1161, 2011. View at Publisher · View at Google Scholar
  • S Domingos-Pereira, L Decrausaz, L Derré, M Bobst, P Romero, J T Schiller, P Jichlinski, and D Nardelli-Haefliger, “Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice,” Mucosal Immunology, vol. 6, no. 2, pp. 393–404, 2012. View at Publisher · View at Google Scholar
  • Jonathan A. Bernstein, “Immunologic disorders of the female and male reproductive tract,” Annals of Allergy, Asthma & Immunology, vol. 108, no. 6, pp. 390–395, 2012. View at Publisher · View at Google Scholar
  • Margaret A. Stanley, “Epithelial Cell Responses to Infection with Human Papillomavirus,” Clinical Microbiology Reviews, vol. 25, no. 2, pp. 215–222, 2012. View at Publisher · View at Google Scholar
  • Andrea L. Radtke, Alison J. Quayle, and Melissa M. Herbst-Kralovetz, “Microbial Products Alter the Expression of Membrane-Associated Mucin and Antimicrobial Peptides in a Three-Dimensional Human Endocervical Epithelial Cell Model,” Biology Of Reproduction, vol. 87, no. 6, 2012. View at Publisher · View at Google Scholar
  • J. -P. Lepargneur, and M. Abbal, “Innate and adaptative immunity of the female genital tract,” Journal de Gynecologie Obstetrique et Biologie de la Reproduction, vol. 41, no. 7, pp. 612–622, 2012. View at Publisher · View at Google Scholar
  • Rodney R. Dietert, “Misregulated infl ammation as an outcome of early-life exposure to endocrine-disrupting chemicals,” Reviews on Environmental Health, vol. 27, no. 2-3, pp. 117–131, 2012. View at Publisher · View at Google Scholar
  • S-M. Lee, K. Suk, and W-H. Lee, “Synthetic peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling through activation of SHP and/or PI3K,” Clinical & Experimental Immunology, vol. 167, no. 3, pp. 438–446, 2012. View at Publisher · View at Google Scholar
  • Eun-Ju Kim, Sang-Min Lee, Kyoungho Suk, and Won-Ha Lee, “CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines,” Immunology, vol. 135, no. 3, pp. 226–235, 2012. View at Publisher · View at Google Scholar
  • Theresa Joseph, Irina A. Zalenskaya, Nazita Yousefieh, Suzanne D. Schriver, Lyn C. Cote, Neelima Chandra, and Gustavo F. Doncel, “Induction of Cyclooxygenase (COX)-2 in Human Vaginal Epithelial Cells in Response to TLR ligands and TNF-α,” American Journal of Reproductive Immunology, vol. 67, no. 6, pp. 482–490, 2012. View at Publisher · View at Google Scholar
  • Clara Bodelon, Margaret M. Madeleine, Lisa G. Johnson, Qin Du, Denise A. Galloway, Mari Malkki, Effie W. Petersdorf, and Stephen M. Schwartz, “Genetic variation in the TLR and NF-κB pathways and cervical and vulvar cancer risk: A population-based case-control study,” International Journal of Cancer, 2013. View at Publisher · View at Google Scholar
  • Karen Racicot, Ingrid Cardenas, Vera Wuensche, Paulomi Aldo, Seth Guller, Robert E. Means, Roberto Romero, and Gil Mor, “Viral Infection of the Pregnant Cervix Predisposes to Ascending Bacterial Infection,” Journal of Immunology, vol. 191, no. 2, pp. 934–941, 2013. View at Publisher · View at Google Scholar
  • Martha Triantafilou, Benjamin De Glanville, Ali F. Aboklaish, O. Brad Spiller, Sailesh Kotecha, and Kathy Triantafilou, “Synergic Activation of Toll-Like Receptor (TLR) 2/6 and 9 in Response to Ureaplasma parvum & urealyticum in Human Amniotic Epithelial Cells,” Plos One, vol. 8, no. 4, 2013. View at Publisher · View at Google Scholar
  • Liping Li, Jing Yang, Lihua Ren, Ning Su, Yichuan Fang, and Yi Lin, “Invariant NKT cells increase lipopolysacchride-induced pregnancy loss by a mechanism involving Th1 and Th17 responses,” Journal of Maternal-Fetal and Neonatal Medicine, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  • Reet Mändar, “Microbiota of male genital tract: Impact on the health of man and his partner,” Pharmacological Research, vol. 69, no. 1, pp. 32–41, 2013. View at Publisher · View at Google Scholar
  • Uma Shanmugasundaram, J. William Critchfield, Jane Pannell, Jean Perry, Linda C. Giudice, Karen Smith-McCune, Ruth M. Greenblatt, and Barbara L. Shacklett, “ Phenotype and Functionality of CD4 + and CD8 + T Cells in the Upper Reproductive Tract of Healthy Premenopausal Women ,” American Journal of Reproductive Immunology, vol. 71, no. 2, pp. 95–108, 2013. View at Publisher · View at Google Scholar
  • Alfredo Amador-Molina, Jose Fernando Hernandez-Valencia, Edmundo Lamoyi, Adriana Contreras-Paredes, and Marcela Lizano, “Role of Innate Immunity against Human Papillomavirus (HPV) Infections and Effect of Adjuvants in Promoting Specific Immune Response,” Viruses-Basel, vol. 5, no. 11, pp. 2624–2642, 2013. View at Publisher · View at Google Scholar
  • Eun-Ju Kim, Kyoungho Suk, and Won-Ha Lee, “SHPS-1 and a synthetic peptide representing its ITIM inhibit the MyD88, but not TRIF, pathway of TLR signaling through activation of SHP and PI3K in THP-1 cells,” Inflammation Research, vol. 62, no. 4, pp. 377–386, 2013. View at Publisher · View at Google Scholar
  • PhilipC Calder, Parveen Yaqoob, F Trejo, and Y Sanz, “Intestinal bacteria and probiotics: effects on the immune system and impacts on human health,” Diet, immunity and inflammation, pp. 267–291, 2013. View at Publisher · View at Google Scholar
  • Małgorzata Krzyzowska, and Karolina Paulina Gregorczyk, “Innate immunity to infection in the lower female genital tract,” Postepy Higieny i Medycyny Doswiadczalnej, vol. 67, pp. 388–401, 2013. View at Publisher · View at Google Scholar
  • Alison Mary Rich, Haizal Mohd Hussaini, Venkata P. B. Parachuru, and Gregory J. Seymour, “Toll-Like Receptors and Cancer, Particularly Oral Squamous Cell Carcinoma,” Frontiers in Immunology, vol. 5, 2014. View at Publisher · View at Google Scholar
  • Karen Racicot, Ja-Young Kwon, Paulomi Aldo, Michelle Silasi, and Gil Mor, “Understanding the Complexity of the Immune System during Pregnancy,” American Journal of Reproductive Immunology, 2014. View at Publisher · View at Google Scholar
  • Anirban Roy, Indranil Chatterjee, Rahul Chowdhury, and Snehasikta Swarnakar, “Landscape of Papillomavirus in Human Cancers: Prevention and Therapeutic Avenues,” Cancer-Causing Viruses and Their Inhibitors, pp. 207–242, 2014. View at Publisher · View at Google Scholar
  • Fabiana Cannella, Alessandra Pierangeli, Carolina Scagnolari, Giulia Cacciotti, Giulia Tranquilli, Patrizia Stentella, Nadia Recine, and Guido Antonelli, “TLR9 is expressed in human papillomavirus-positive cervical cells and is overexpressed in persistent infections,” Immunobiology, 2014. View at Publisher · View at Google Scholar
  • Guoku Hu, Yaoyu Feng, Steven P. O’Hara, and Xian-Ming Chenpp. 423–454, 2014. View at Publisher · View at Google Scholar
  • Yanyan Yang, Woo Seok Yang, Tao Yu, Young-Su Yi, Jae Gwang Park, Deok Jeong, Ji Hye Kim, Jeong Su Oh, Keejung Yoon, Jong-Hoon Kim, and Jae Youl Cho, “Novel anti-inflammatory function of NSC95397 by the suppression of multiple kinases,” Biochemical Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Margaret A. Stanley, and Jane C. Sterling, “Host responses to infection with human papillomavirus,” Current Problems in Dermatology (Switzerland), vol. 45, pp. 58–74, 2014. View at Publisher · View at Google Scholar
  • Małgorzata Pawlikowska-Warych, and Wiesław Deptuła, “Chlamydiosis of urogenitary tract in humans,” Postepy Higieny i Medycyny Doswiadczalnej, vol. 68, pp. 419–427, 2014. View at Publisher · View at Google Scholar
  • Fatemehsadat Amjadi, Ensieh Salehi, Mehdi Mehdizadeh, and Reza Aflatoonian, “Role of the innate immunity in female reproductive tract.,” Advanced biomedical research, vol. 3, pp. 1, 2014. View at Publisher · View at Google Scholar
  • Margaret Stanley, “Immunology of HPV Infection,” Current Obstetrics and Gynecology Reports, 2015. View at Publisher · View at Google Scholar
  • Muriel Aldunate, Daniela Srbinovski, Anna C. Hearps, Catherine F. Latham, Paul A. Ramsland, Raffi Gugasyan, Richard A. Cone, and Gilda Tachedjian, “Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis,” Frontiers in Physiology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Irina A. Zalenskaya, Theresa Joseph, Jasmin Bavarva, Nazita Yousefieh, Suzanne S. Jackson, Titilayo Fashemi, Hidemi S. Yamamoto, Robert Settlage, Raina N. Fichorova, and Gustavo F. Doncel, “Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarke,” Plos One, vol. 10, no. 6, 2015. View at Publisher · View at Google Scholar
  • Marta Rodriguez Garcia, Mickey V. Patel, Zheng Shen, John V. Fahey, Nabanita Biswas, Jiri Mestecky, and Charles R. Wiravol. 2-2, pp. 2097–2124, 2015. View at Publisher · View at Google Scholar
  • María E. Fátima Nader-Macías, and María Silvina Juárez Tomás, “Profiles and technological requirements of urogenital probiotics,” Advanced Drug Delivery Reviews, 2015. View at Publisher · View at Google Scholar
  • Reet Mändar, Margus Punab, Natalja Borovkova, Eleri Lapp, Riinu Kiiker, Paul Korrovits, Andres Metspalu, Kaarel Krjutškov, Hiie Nõlvak, Jens-Konrad Preem, Kristjan Oopkaup, Andres Salumets, and Jaak Truu, “Complementary seminovaginal microbiome in couples,” Research in Microbiology, 2015. View at Publisher · View at Google Scholar
  • Nan-Xin Zheng, Yan Wang, Dan-Dan Hu, Lan Yan, and Yuan-Ying Jiang, “ The role of pattern recognition receptors in the innate recognition of Candida albicans ,” Virulence, pp. 00–00, 2015. View at Publisher · View at Google Scholar
  • Z. Zandieh, M. Ashrafi, B. Jameie, S. Amanpour, N. Mosaffa, R. Salman Yazdi, A. Pacey, and R. Aflatoonian, “Evaluation of immunological interaction between spermatozoa and fallopian tube epithelial cells,” Andrologia, 2015. View at Publisher · View at Google Scholar
  • Ml Falsetta, Dc Foster, Ad Bonham, and Rp Phipps, “A review of the available clinical therapies for vulvodynia management and new data implicating proinflammatory mediators in pain elicitation,” BJOG: An International Journal of Obstetrics & Gynaecology, 2016. View at Publisher · View at Google Scholar
  • Solat Eslami, Jamshid Hadjati, Elahe Motevaseli, Reza Mirzaei, Samad Farashi Bonab, Bita Ansaripour, and Mohammad Reza Khoramizadeh, “ Lactobacillus crispatus strain SJ-3C-US induces human dendritic cells (DCs) maturation and confers an anti-inflammatory phenotype to DCs ,” Apmis, 2016. View at Publisher · View at Google Scholar
  • Martina Kutmon, Kristina Hanspers, Alexander R. Pico, Chris T. Evelo, Anwesha Bohler, Guanming Wu, Leontius Adhika Pradhana, Susan L. Coort, and Robin Haw, “Reactome from a WikiPathways Perspective,” PLoS Computational Biology, vol. 12, no. 5, 2016. View at Publisher · View at Google Scholar
  • Nunzia Zanotta, Maria Lina Tornesello, Clorinda Annunziata, Giovanni Stellato, Franco Maria Buonaguro, and Manola Comar, “Candidate Soluble Immune Mediators in Young Women with High-Risk Human Papillomavirus Infection: High Expression of Chemokines Promoting Angiogenesis ,” Plos One, vol. 11, no. 3, 2016. View at Publisher · View at Google Scholar
  • Collynn F. Woeller, Stephen J. Pollock, Adrienne D. Bonham, Richard P. Phipps, Megan L. Falsetta, David C. Foster, and Constantine G. Haidaris, “A Role for Bradykinin Signaling in Chronic Vulvar Pain,” Journal of Pain, vol. 17, no. 11, pp. 1183–1197, 2016. View at Publisher · View at Google Scholar
  • Anthonio O. Adefuye, Henry A. Adeola, Kurt J. Sales, and Arieh A. Katz, “Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract,” Journal of Immunology Research, vol. 2016, pp. 1–13, 2016. View at Publisher · View at Google Scholar
  • Ying Chen, Elizabeth Bruning, Joseph Rubino, and Scott E Eder, “Role of female intimate hygiene in vulvovaginal health: Global hygiene practices and product usage,” Women's Health, pp. 174550571773101, 2017. View at Publisher · View at Google Scholar
  • Alina Steinbach, and Angelika B. Riemer, “Immune evasion mechanisms of human papillomavirus: An update,” International Journal of Cancer, 2017. View at Publisher · View at Google Scholar
  • S. Kovachev, “Defence factors of vaginal lactobacilli,” Critical Reviews in Microbiology, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Fernanda Costa Brandão Berti, Ana Paula Lombardi Pereira, Guilherme Cesar Martelossi Cebinelli, Kleber Paiva Trugilo, and Karen Brajão de Oliveira, “The role of interleukin 10 in human papilloma virus infection and progression to cervical carcinoma,” Cytokine & Growth Factor Reviews, vol. 34, pp. 1–13, 2017. View at Publisher · View at Google Scholar
  • Behnia S. Lashkari, and Dilly O. C. Anumba, “Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4,” Plos One, vol. 12, no. 3, pp. e0173646, 2017. View at Publisher · View at Google Scholar
  • Brandie D. Taylor, Patricia A. Totten, Sabina G. Astete, Michael J. Ferris, David H. Martin, Roberta B. Ness, and Catherine L. Haggerty, “ Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease ,” American Journal of Reproductive Immunology, pp. e12804, 2017. View at Publisher · View at Google Scholar
  • Mickey V. Patel, Zheng Shen, Richard M. Rossoll, and Charles R. Wira, “Estradiol-regulated innate antiviral responses of human endometrial stromal fibroblasts,” American Journal of Reproductive Immunology, pp. e13042, 2018. View at Publisher · View at Google Scholar
  • Hossein Motedayyen, Farshid Fathi, Mahdi Fasihi-Ramandi, and Ramezan Ali Taheri, “The effect of lipopolysaccharide on anti-inflammatory and pro-inflammatory cytokines production of human amniotic epithelial cells,” Reproductive Biology, 2018. View at Publisher · View at Google Scholar
  • Shasha Yang, Lan Liu, Dongyuan Xu, and Xiangdan Li, “The Relationship of the TLR9 and TLR2 Genetic Polymorphisms with Cervical Cancer Risk: a Meta-Analysis of Case-Control Studies,” Pathology & Oncology Research, 2018. View at Publisher · View at Google Scholar
  • Fernando Real, Alexis Sennepin, Yonatan Ganor, Alain Schmitt, and Morgane Bomsel, “Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection,” Cell Reports, vol. 23, no. 6, pp. 1794–1805, 2018. View at Publisher · View at Google Scholar
  • Mickey V. Patel, Zheng Shen, and Charles R. Wira, “Poly (I:C) and LPS Induce Distinct Immune Responses by Ovarian Stromal Fibroblasts,” Journal of Reproductive Immunology, 2018. View at Publisher · View at Google Scholar
  • Lucas Boeno Oliveira, Ismar R. Haga, and Luisa Lina Villa, “Human papillomavirus (HPV) 16 E6 oncoprotein targets the Toll-like receptor pathway,” Journal of General Virology, 2018. View at Publisher · View at Google Scholar
  • Stephanie Triseptya Hunto, Kon Kuk Shin, Han Gyung Kim, Sang Hee Park, Junsang Oh, Gi-Ho Sung, Mohammad Amjad Hossain, Ho Sik Rho, Jongsung Lee, Jong-Hoon Kim, and Jae Youl Cho, “ Phosphatidylinositide 3-Kinase Contributes to the Anti-Inflammatory Effect of Abutilon crispum L. Medik Methanol Extract ,” Evidence-Based Complementary and Alternative Medicine, vol. 2018, pp. 1–10, 2018. View at Publisher · View at Google Scholar
  • Gordana Halec, Mark E. Scott, Sepideh Farhat, Teresa M. Darragh, and Anna-Barbara Moscicki, “Toll-like receptors: Important immune checkpoints in the regression of cervical intra-epithelial neoplasia 2,” International Journal of Cancer, 2018. View at Publisher · View at Google Scholar
  • Emel Alan, and Narin Liman, “Toll-like receptor expression patterns in the rat uterus during post partum involution,” Reproduction, Fertility and Development, vol. 30, no. 2, pp. 330, 2018. View at Publisher · View at Google Scholar
  • Fatemehsadat Amjadi, Zahra Zandieh, Ensieh Salehi, Reza Jafari, Nasrin Ghasemi, Abbas Aflatoonian, Alireza Fazeli, and Reza Aflatoonian, “Variable localization of Toll-like receptors in human fallopian tube epithelial cells,” Clinical and Experimental Reproductive Medicine, vol. 45, no. 1, pp. 1, 2018. View at Publisher · View at Google Scholar
  • Zahra Zandieh, Fatemehsadat Amjadi, Haghighat Vakilian, Khashayar Aflatoonian, Elham Amirchaghmaghi, Alireza Fazeli, and Reza Aflatoonian, “Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells,” Clinical and Experimental Reproductive Medicine, vol. 45, no. 4, pp. 154, 2018. View at Publisher · View at Google Scholar
  • Eillen Tecle, Hector Sequoyah Reynoso, Ruixuan Wang, and Pascal Gagneux, “The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival,” Journal of Biological Chemistry, vol. 294, no. 31, pp. 11910–11919, 2019. View at Publisher · View at Google Scholar
  • Salim S Abdool Karim, Cheryl Baxter, Jo‐Ann S Passmore, Lyle R McKinnon, and Brent L Williams, “The genital tract and rectal microbiomes: their role in HIV susceptibility and prevention in women,” Journal of the International AIDS Society, vol. 22, no. 5, pp. e25300, 2019. View at Publisher · View at Google Scholar
  • A. Said Álamos-Musre, Alejandro Escobar, Cecilia V. Tapia, Myron Christodoulides, and Paula I. Rodas, “Use of Human Fallopian Tube Organ in Culture (FTOC) and Primary Fallopian Tube Epithelial Cells (FTEC) to Study the Biology of Neisseria gonorrhoeae Infection,” Neisseria gonorrhoeae, vol. 1997, pp. 377–402, 2019. View at Publisher · View at Google Scholar
  • Alba Martín-Moreno, Daniel Sepúlveda-Crespo, Mª Jesús Serramía-Lobera, Ana Judith Perisé-Barrios, and Mª Angeles Muñoz-Fernández, “G2-S16 dendrimer microbicide does not interfere with the vaginal immune system,” Journal of Nanobiotechnology, vol. 17, no. 1, 2019. View at Publisher · View at Google Scholar
  • Han Gyung Kim, Woo Seok Yang, Yo Han Hong, Dae-Hyuk Kweon, Jongsung Lee, Sunggyu Kim, and Jae Youl Cho, “Anti-inflammatory functions of the CDC25 phosphatase inhibitor BN82002 via targeting AKT2,” Biochemical Pharmacology, 2019. View at Publisher · View at Google Scholar
  • Hossein Motedayyen, Farshid Fathi, Mahdi Fasihi-Ramandi, Ramezan Ali Taheri, and Ali Mohammad Sabzghabaee, “Toll-like receptor 4 activation on human amniotic epithelial cells is a risk factor for pregnancy loss,” Journal of Research in Medical Sciences, vol. 24, no. 1, 2019. View at Publisher · View at Google Scholar