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Mediators of Inflammation
Volume 2010 (2010), Article ID 985614, 8 pages
http://dx.doi.org/10.1155/2010/985614
Clinical Study

Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels

1Department of Anaesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
2Department of Anaesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Baltimore, MD 21287, USA
3Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Rudolf-Buchheim-Straße 7, 35392 Giessen, Germany
4Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
5Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
6Department of Medicine, Faculty of Clinical Medicine, University of Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

Received 22 February 2010; Accepted 30 June 2010

Academic Editor: Eeva Moilanen

Copyright © 2010 Thorsten Brenner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock ( ) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers ( ) were collected once; samples from postoperative patients ( ) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: : ). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.