Mediators of Inflammation / 2011 / Article / Fig 2

Review Article

Thrombospondin-1: Multiple Paths to Inflammation

Figure 2

Dual role of CD-36—TSP-1 interaction in inflammation. Expression of CD36 is positively regulated by PPARγ and negatively regulated by TGFβ. As an integral membrane protein, CD36 binds many ligands including TSP-1. The CD36-TSP-1 interaction involves conformational changes in TSP-1. This interaction mediates apoptotic effects via the CD47-dependent pathway, which has multiple effects. The CD36-TSP-1 interaction can also activate macrophage TGFβ1 and the NFκB pathway *[98, 99], **[100102], [100], [103]. Blue shading indicates pathways occurring in endothelial cells, pink shading in macrophages, and yellow shading in epithelial cells.

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