Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats

Figure 1

PDTC and DEX pretreatment prolonged the seizure onset time in KA induced rats. Mean values for the seizure onset time to grade III (SOT3, A) and grade V (SOT5, B) as the latencies to seizure of each group. SOT3 in the PDTC and DEX pretreated groups was 89.58±39.28 min and 87.92±45.80 min, respectively, compared to 67.50±22.91 min in EP group. SOT5 in the PDTC and DEX pretreated groups was 104.17±39.07 min and 103.33±51.27 min, respectively, compared to 74.58±22.10 min in EP group. (*𝑃<.05, versus EP group).

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