Gene Expression Profiling in Lungs of Chronic Asthmatic Mice Treated with Galectin-3: Downregulation of Inflammatory and Regulatory Genes

Table 1

Genes included in upregulated gene ontology pathways in OVA versus pEGFP-GAL 3 comparison.

Biological process (GO database)	Genes
Inflammatory response	IDO1, IL17A, IL17B, IL17F, IL1A, IL25, TGFB1, IL6, IL4, FOXP3, JAK2, STAT5A, TLR4
Regulation of immunoglobulin mediated immune response	BCL6, FOXP3, FCG2B, IGH7, TNF, TGFB1, IL4, STAT6, IGH1A, IGH3, IGH7, C3, IL27RA
Negative regulation of inflammatory response	IL10, FOXP3, TGFB, SOCS3, IL2, TNF1B, AD, FOXF1A, IL2RA, ZFP36
Cytokine biosynthetic process	ADAM3, GATA3, IGF2BP1, IL12B, MAP2K3, IL6, FOXP3, IL-10, NFKB1, BCL3, INFG, IL1B, TNF, WNT5A, IL21, IL1A, STAT5, IL17F
T-cell-mediated immunity	IL4RA, BCL6, TGFB, IL20RB, IL2RA, IDO, FOXP3, CD27, CD74, LAG3, CASP3
Cytokine and chemokine mediated signalling pathway	ILR1, IL23R, IL2RB, IL3, IL5, JAK1, JAK3, SOCS1, SOCS3, SOCS5, STAT1, STAT3, STAT5A, STAT5B, IL6, IL6RA, TNF
Leukocyte degranulation	P4K2A, RAB27A, IGH7, HMOX1, FOXF1A, FCER1A, FCER1G, PRAM1

GO: Gene Ontology.