Angiogenesis-Related Cytokines, RANKL, and Osteoprotegerin in Multiple Myeloma Patients in relation to Clinical Features and Response to Treatment

Table 2

Mean ± SD values of the measured parameters in the group of MM patients in different disease stages.

	Stage	Mean ± SD	𝑃
OPG (pmol/L)	1	16.5±16.2	NS
	2	11.1±9.2
	3	10.4±7.9
RANKL pmol/L	1	72.01±64.05	< 0.001
	2	235.29±107.45
	3	739.98±445.84
RANKL/OPG	1	7.62±8.90	< 0.001
	2	48.63±84.75
	3	91.87±63.71
HGF (pg/mL)	1	804.3±294.9	< 0.001
	2	1547±469.1
	3	2356.8±1466.1
LDH (IU/L)	1	180.4±31.1	< 0.002
	2	218.5±62.2
	3	280.2±88.9
VEGF (pg/mL)	1	140.1±105.0	< 0.001
	2	230.9±141.8
	3	425.1±150.8
B2M (mg/dL)	1	2.1±0.9	< 0.001
	2	4.4±5.3
	3	4.8±3.2
CRP (mg/L)	1	1.5±2.1	NS
	2	0.9±0.7
	3	1.1±0.6
IL-6 (pg/mL)	1	3.4±2.1	< 0.001
	2	5.8±2.7
	3	9.5±6.9