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Mediators of Inflammation
Volume 2011 (2011), Article ID 916807, 6 pages
Clinical Study

Serum Adiponectin, Resistin, and Circulating Soluble Receptor for Advanced Glycation End Products in Colectomy Patients

1Spectrum Health Research, Spectrum Health, 25 Michigan Avenue NE, Grand Rapids, MI 49503, USA
2Department of Colorectal Surgery, Spectrum Health, 4100 Lake Drive NE, Suite 205, Grand Rapids, MI 49546, USA
3Laboratory of Microarray Technology, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA
4Laboratory of Analytical, Cellular, and Molecular Microscopy, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA
5Division of Colorectal Surgery, Department of Surgery, Keck School of Medicine, USC, 1441 Eastlake Avenue, Suite 7418, Los Angeles, CA 90033-4612, USA

Received 27 May 2011; Accepted 26 June 2011

Academic Editor: Fulvio D'Acquisto

Copyright © 2011 Theodor Asgeirsson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. Surgical trauma and associated complications are frequently related to physiological stress during colectomy. This study evaluated the response of adiponectin, resistin, and circulating soluble receptor for advanced glycation end products (sRAGE) in colectomy patients with or without an enhanced recovery protocol. Method. Serum samples were collected from 44 colectomy patients at 3 timframes. The surgical procedures were laparoscopic (LAP), hand-assisted laparoscopic (HALS), or open colectomy (OPEN). Adiponectin, resistin, and sRAGE levels were determined by ELISA. Repeated measures ANOVA was applied and values < 0.05 were considered significant. Results. A total of 132 (44 × 3) sera were used for analysis. Levels of adiponectin was significantly decreased between PREOP and POD3 ( ). Conversely, concentrations of resistin significantly increased from PREOP to POD1 and returned to baseline value by POD3 ( ). Serum sRAGE levels were significantly higher in LAP in comparison with HALS ( ) and OPEN ( ). sRAGE levels were significantly higher in sera of patients that underwent ERP ( ). Conclusions. Serum adiponectin, resistin, and sRAGE have the potential to develop into a panel of stress markers. Higher sRAGE levels in sera of LAP and ERP patients may be indicative of a protective and syngeristic role for colectomy recovery.