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Mediators of Inflammation
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Mediators of Inflammation
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2011
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Article
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Tab 1
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Review Article
Cross-Talk between Apolipoprotein E and Cytokines
Table 1
The main differences among human apoE isoforms.
Isoform
AA residues
Domain interaction
Binding to LDLR
Lipoprotein-binding preference
112
158
ApoE 2
Cysteine
Cysteine
No
Low affinity
HDL
ApoE 3
Cysteine
Arginine
No
High affinity
HDL
ApoE 4
Arginine
Arginine
Yes
High affinity
LDL
AA = amino acid.
LDLR = low density lipoprotein receptor.