A Comparative In Vitro Study of the Effects of Separate and Combined Products of Citrus e fructibus and Cydonia e fructibus on Immunological Parameters of Seasonal Allergic Rhinitis
Table 3
Differences in mean scores after seven-day PBMC cultures in the SAR group, healthy group, and total group (grass pollen stimulation minus medium stimulation).
Citrus
Cydonia
Citrus/Cydonia
value Citrus versus Cydonia
value Citrus versus Citrus/Cydonia
value Cydonia versus Citrus/Cydonia
IL-10
SAR
88.4 (28.5)
101.4 (19.5)
115.2 (36.2)
n.s.
n.s.
n.s.
Healthy
76.4 (38.2)
107.4 (16.5)
102.4 (26.1)
n.s.
n.s.
n.s.
Total group
82.4 (32.4)
104.4 (17.3)
108.8 (30.5)
n.s.
n.s.
IL-5
SAR
509,8 (126.6)
727.6 (95.5)
619.0 (87.7)
n.s.
n.s.
Healthy
358.0 (81.3)
575.8 (98.6)
711.4 (144.7)
n.s.
Total group
433.9 (128.3)
651.7 (121.6)
665.2 (122.9)
n.s.
IL-13
SAR
1470 (390.3)
1823.0 (185.7)
1917.2 (277.7)
n.s.
n.s.
Healthy
1589.2 (300.2)
1864.2 (102.0)
1765.4 (186.6)
n.s.
n.s.
n.s.
Total group
1529.6 (334.2)
1843.6 (142.9)
1841.3 (237.0)
n.s.
n.s.
n.s.
IFN-γ
SAR
666.8 (126.2)
724.0 (105.2)
621.4 (90.8)
n.s.
n.s.
n.s.
Healthy
558.0 (130.1)
692.0 (58.4)
571.4 (57.1)
n.s.
n.s.
Total group
612.4 (133.7)
708.0 (82.0)
596.4 (76.2)
n.s.
IFN-γ/ IL-5
SAR
1.4 (0.5)
1.0 (0.2)
1.0 (0.2)
n.s.
n.s.
n.s.
Healthy
1.6 (0.4)
1.2 (0.2)
0.8 (0.2)
n.s.
Total group
1.5 (0.4)
1.1 (0.2)
0.9 (0.2)
n.s.
IFN-γ/ IL-13
SAR
0.5 (0.1)
0.4 (0.1)
0.3 (0.1)
n.s.
n.s.
n.s.
Healthy
0.4 (0.1)
0.4 (0.1)
0.3 (<0.1)
n.s.
n.s.
n.s.
Total group
0.4 (0.1)
0.4 (0.1)
0.3 (0.1)
n.s.
n.s.
n.s.
IL-10/ IL-5
SAR
0.2 (0.1)
0.1 (<0.1)
0.2 (0.1)
n.s.
n.s.
n.s.
Healthy
0.2 (0.1)
0.2 (0.1)
0.2 (0.1)
n.s.
n.s.
n.s.
Total group
0.2 (0.1)
0.2 (<0.1)
0.2 (0.1)
n.s.
n.s.
n.s.
IL-10/ IL-13
SAR
0.1 (<0.1)
0.1 (<0.1)
0.1 (<0.1)
n.s.
n.s.
n.s.
Healthy
<0.1 (<0.1)
0.1 (<0.1)
0.1 (<0.1)
n.s.
n.s.
n.s.
Total group
0.1 (<0.1)
0.1 (<0.1)
0.1 (<0.1)
n.s.
n.s.
n.s.
* The mean score (SD) in pg/mL is presented for all cytokine measurements; n.s., not significant.
