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Mediators of Inflammation
Volume 2012, Article ID 125458, 14 pages
http://dx.doi.org/10.1155/2012/125458
Review Article

Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases

1SERGAS, Santiago University Clinical Hospital and NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Building C, Level-2, 15706 Santiago de Compostela, Spain
2Division of Rheumatology, Fundación Jiménez Diaz, 2-28040 Madrid, Spain
3SERGAS, Santiago University Clinical Hospital and Division of Orthopaedics Surgery and Traumatology, 15706 Santiago de Compostela, Spain
4SERGAS, Santiago University Clinical Hospital and Laboratory of Genetics in Rheumatic Diseases, Institute of Medical Research (IDIS), Building C, Level-2, 15706 Santiago de Compostela, Spain
5SERGAS, Santiago University Clinical Hospital and Research Laboratory 7 (Molecular and Cellular Cardiology), Institute of Medical Research (IDIS), 15706 Santiago de Compostela, Spain

Received 6 June 2012; Accepted 19 June 2012

Academic Editor: Miguel A. González-Gay

Copyright © 2012 Morena Scotece et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. N. Tyrrell, J. Beyene, B. M. Feldman, B. W. McCrindle, E. D. Silverman, and T. J. Bradley, “Rheumatic disease and carotid intima-media thickness: a systematic review and meta-analysis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 5, pp. 1014–1026, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. S. M. Naz and D. P. Symmons, “Mortality in established rheumatoid arthritis,” Best Practice & Research Clinical Rheumatology, vol. 21, no. 5, pp. 871–883, 2007. View at Google Scholar
  3. S. Van Doornum, G. McColl, and I. P. Wicks, “Accelerated atherosclerosis: an extraarticular feature of rheumatoid arthritis?” Arthritis and Rheumatism, vol. 46, no. 4, pp. 862–873, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Erb, A. V. Pace, K. M. J. Douglas, M. J. Banks, and G. D. Kitas, “Risk assessment for coronary heart disease in rheumatoid arthritis and osteoarthritis,” Scandinavian Journal of Rheumatology, vol. 33, no. 5, pp. 293–299, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Svenungsson, K. Jensen-Urstad, M. Heimbürger et al., “Risk factors for cardiovascular disease in systemic lupus erythematosus,” Circulation, vol. 104, no. 16, pp. 1887–1893, 2001. View at Google Scholar · View at Scopus
  6. J. Frostegard, “Atherosclerosis in patients with autoimmune disorders,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 9, pp. 1776–1785, 2005. View at Google Scholar
  7. D. Malesci, A. Niglio, G. A. Mennillo, R. Buono, G. Valentini, and G. La Montagna, “High prevalence of metabolic syndrome in patients with ankylosing spondylitis,” Clinical Rheumatology, vol. 26, no. 5, pp. 710–714, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Lago, C. Dieguez, J. Gómez-Reino, and O. Gualillo, “The emerging role of adipokines as mediators of inflammation and immune responses,” Cytokine and Growth Factor Reviews, vol. 18, no. 3-4, pp. 313–325, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. Y. Li, P. Wangand, and C. Y. Miao, “Adipokines in inflammation, insulin resistance and cardiovascular disease,” Clinical and Experimental Pharmacology and Physiology, vol. 38, no. 12, pp. 888–896, 2011. View at Google Scholar
  10. Y. Cho, S. E. Lee, H. C. Lee et al., “Adipokine resistin is a key player to modulate monocytes, endothelial cells, and smooth muscle cells, leading to progression of atherosclerosis in rabbit carotid artery,” Journal of the American College of Cardiology, vol. 57, no. 1, pp. 99–109, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Schneiderman, A. J. Simon, M. R. Schroeter, M. Y. Flugelman, S. Konstantinides, and K. Schaefer, “Leptin receptor is elevated in carotid plaques from neurologically symptomatic patients and positively correlated with augmented macrophage density,” Journal of Vascular Surgery, vol. 48, no. 5, pp. 1146–1155, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman, “Positional cloning of the mouse obese gene and its human homologue,” Nature, vol. 372, no. 6505, pp. 425–432, 1994. View at Publisher · View at Google Scholar · View at Scopus
  13. R. S. Ahlma, D. Prabakaran, C. Mantzoros et al., “Role of leptin in the neuroendocrine response to fasting,” Nature, vol. 382, no. 6588, pp. 250–252, 1996. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Gualillo, S. Eiras, F. Lago, C. Diéguez, and F. F. Casanueva, “Elevated serum leptin concentrations induced by experimental acute inflammation,” Life Sciences, vol. 67, no. 20, pp. 2433–2441, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Beltowski, “Leptin and atherosclerosis,” Atherosclerosis, vol. 189, no. 1, pp. 47–60, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. R. W. O'Rourke, “Inflammation in obesity-related diseases,” Surgery, vol. 145, no. 3, pp. 255–259, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Sierra-Johnson, A. Romero-Corral, F. Lopez-Jimenez et al., “Relation of increased leptin concentrations to history of myocardial infarction and stroke in the United States population,” American Journal of Cardiology, vol. 100, no. 2, pp. 234–239, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Karaduman, C. Oktenli, U. Musabak et al., “Leptin, soluble interleukin-6 receptor, C-reactive protein and soluble vascular cell adhesion molecule-1 levels in human coronary atherosclerotic plaque,” Clinical and Experimental Immunology, vol. 143, no. 3, pp. 452–457, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. H. G. Rus, R. Vlaicu, and F. Niculescu, “Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall,” Atherosclerosis, vol. 127, no. 2, pp. 263–271, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. T. P. Zwaka, V. Hombach, and J. Torzewski, “C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis,” Circulation, vol. 103, no. 9, pp. 1194–1197, 2001. View at Google Scholar · View at Scopus
  21. A. Zeidan, D. M. Purdham, V. Rajapurohitam, S. Javadov, S. Chakrabarti, and M. Karmazyn, “Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy,” Journal of Pharmacology and Experimental Therapeutics, vol. 315, no. 3, pp. 1075–1084, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Li, J. C. Mamputu, N. Wiernsperger, and G. Renier, “Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin,” Diabetes, vol. 54, no. 7, pp. 2227–2234, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Y. Park, H. M. Kwon, H. J. Lim et al., “Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro,” Experimental and Molecular Medicine, vol. 33, no. 2, pp. 95–102, 2001. View at Google Scholar · View at Scopus
  24. P. Quehenberger, M. Exner, R. Sunder-Plassmann et al., “Leptin induces endothelin-1 in endothelial cells in vitro,” Circulation Research, vol. 90, no. 6, pp. 711–718, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. F. Maingrette and G. Renier, “Leptin increases lipoprotein lipase secretion by macrophages: involvement of oxidative stress and protein kinase C,” Diabetes, vol. 52, no. 8, pp. 2121–2128, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Nakata, T. Yada, N. Soejima, and I. Maruyama, “Leptin promotes aggregation of human platelets via the long form of its receptor,” Diabetes, vol. 48, no. 2, pp. 426–429, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Corsonello, A. Malara, R. Ientile, and F. Corica, “Leptin enhances adenosine diphosphate-induced platelet aggregation in healthy subjects,” Obesity Research, vol. 10, no. 4, p. 306, 2002. View at Google Scholar · View at Scopus
  28. P. Singh, M. Hoffmann, R. Wolk, A. S. M. Shamsuzzaman, and V. K. Somers, “Leptin induces C-reactive protein expression in vascular endothelial cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 9, pp. e302–e307, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Singh, T. E. Peterson, F. H. Sert-Kuniyoshi, M. D. Jensen, and V. K. Somers, “Leptin upregulates caveolin-1 expression: implications for development of atherosclerosis,” Atherosclerosis, vol. 217, no. 2, pp. 499–502, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. P. G. Frank, G. S. Hassan, J. A. Rodriguez-Feo, and M. P. Lisanti, “Caveolae and caveolin-1: novel potential targets for the treatment of cardiovascular disease,” Current Pharmaceutical Design, vol. 13, no. 17, pp. 1761–1769, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Fernández-Hernando, J. Yu, Y. Suárez et al., “Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis,” Cell Metabolism, vol. 10, no. 1, pp. 48–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Singh, T. E. Peterson, K. R. Barber et al., “Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells,” Biochemical and Biophysical Research Communications, vol. 392, no. 1, pp. 47–52, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. H. R. Lijnen, “Pleiotropic functions of plasminogen activator inhibitor-1,” Journal of Thrombosis and Haemostasis, vol. 3, no. 1, pp. 35–45, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. B. E. Sobel, D. J. Taatjes, and D. J. Schneider, “Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 11, pp. 1979–1989, 2003. View at Google Scholar
  35. D. T. Eitzman, R. J. Westrick, Z. Xu, J. Tyson, and D. Ginsburg, “Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery,” Blood, vol. 96, no. 13, pp. 4212–4215, 2000. View at Google Scholar · View at Scopus
  36. J. Schneiderman, M. S. Sawdey, M. R. Keeton et al., “Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 15, pp. 6998–7002, 1992. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Takeda and G. Karsenty, “Molecular bases of the sympathetic regulation of bone mass,” Bone, vol. 42, no. 5, pp. 837–840, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Otero, J. J. Gomez Reino, and O. Gualillo, “Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-γ in human chondrocytes and ATDC5 chondrogenic cells,” Arthritis and Rheumatism, vol. 48, no. 2, pp. 404–409, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Otero, R. Logo, R. Gomez et al., “Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 65, no. 9, pp. 1198–1201, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. T. Yoshino, N. Kusunoki, N. Tanaka et al., “Elevated serum levels of resistin, leptin, and adiponectin are associated with c-reactive protein and also other clinical conditions in rheumatoid arthritis,” Internal Medicine, vol. 50, no. 4, pp. 269–275, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Hizmetli, M. Kisa, N. Gokalp, and M. Z. Bakici, “Are plasma and synovial fluid leptin levels correlated with disease activity in rheumatoid arthritis?” Rheumatology International, vol. 27, no. 4, pp. 335–338, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. S. W. Lee, M. C. Park, Y. B. Park, and S. K. Lee, “Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis,” Rheumatology International, vol. 27, no. 6, pp. 537–540, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. B. Targońska-Stȩpniak, M. Majdan, and M. Dryglewska, “Leptin serum levels in rheumatoid arthritis patients: relation to disease duration and activity,” Rheumatology International, vol. 28, no. 6, pp. 585–591, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Targonska-Stepniak, M. Dryglewska, and M. Majdan, “Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis,” Rheumatology International, vol. 30, no. 6, pp. 731–737, 2008. View at Google Scholar
  45. S. M. Olama, M. K. Senna, and M. Elarman, “Synovial/serum leptin ratio in rheumatoid arthritis: the association with activity and erosion,” Rheumatology International, vol. 32, no. 3, pp. 683–690, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. M. A. Gonzalez-Gay, M. T. Garcia-Unzueta, A. Berja et al., “Anti-TNF-α therapy does not modulate leptin in patients with severe rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 27, no. 2, pp. 222–228, 2009. View at Google Scholar · View at Scopus
  47. C. Gonzalez-Juanatey, J. Llorca, A. Sanchez Andrade, C. Garcia-Porrua, J. Martin, and M. A. Gonzalez-Gay, “Short-term adalimumab therapy improves endothelial function in patients with rheumatoid arthritis refractory to infliximab,” Clinical and Experimental Rheumatology, vol. 24, no. 3, pp. 309–312, 2006. View at Google Scholar · View at Scopus
  48. M. A. Gonzales-Gay, M. T. Garcia-Unzueta, J. M. De Matias et al., “Influence of anti-TNF-α infliximab therapy on adhesion molecules associated with atherogenesis in patients with rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 24, no. 4, pp. 373–379, 2006. View at Google Scholar · View at Scopus
  49. C. Gonzalez-Juanatey, A. Testa, A. Garcia-Castelo et al., “HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis,” American Journal of Medicine, vol. 114, no. 8, pp. 647–652, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. L. Rodríguez-Rodríguez, C. González-Juanatey, R. Palomino-Morales et al., “TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis,” Atherosclerosis, vol. 216, no. 1, pp. 125–130, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. L. Rodriguez-Rodriguez, C. Gonzalez-Juanatey, M. Garcia-Bermudez et al., “CCR5Delta32 variant and cardiovascular disease in patients with rheumatoid arthritis: a cohort study,” Arthritis Research & Therapy, vol. 13, no. 4, p. R133, 2011. View at Google Scholar
  52. M. García-Bermúdez, C. González-Juanatey, L. Rodríguez-Rodríguez et al., “Lack of association between LEP rs2167270 (19 G>A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 29, no. 2, pp. 293–298, 2011. View at Google Scholar · View at Scopus
  53. D. A. Fraser, J. Thoen, J. E. Reseland, O. Førre, and J. Kjeldsen-Kragh, “Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation,” Clinical Rheumatology, vol. 18, no. 5, pp. 394–401, 1999. View at Publisher · View at Google Scholar · View at Scopus
  54. P. Härle, P. Sarzi-Puttini, M. Cutolo, and R. H. Straub, “No change of serum levels of leptin and adiponectin during anti-tumour necrosis factor antibody treatment with adalimumab in patients with rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 65, no. 7, pp. 970–971, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. C. S. Derdemezis, T. D. Filippatos, P. V. Voulgari, A. D. Tselepis, A. A. Drosos, and D. N. Kiortsis, “Effects of a 6-month infliximab treatment on plasma levels of leptin and adiponectin in patients with rheumatoid arthritis,” Fundamental and Clinical Pharmacology, vol. 23, no. 5, pp. 595–600, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. L. Otvos, W. H. Shao, A. S. Vanniasinghe et al., “Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis,” Peptides, vol. 32, no. 8, pp. 1567–1574, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. K. M. Tong, D. C. Shieh, C. P. Chen et al., “Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-κB/p300 binding in human synovial fibroblasts,” Cellular Signalling, vol. 20, no. 8, pp. 1478–1488, 2008. View at Publisher · View at Google Scholar · View at Scopus
  58. C. Procaccini, F. Carbone, M. Galgani et al., “Obesity and susceptibility to autoimmune diseases,” Expert Review of Clinical Immunology, vol. 7, no. 3, pp. 287–294, 2011. View at Publisher · View at Google Scholar · View at Scopus
  59. C. A. Notleyand and M. R. Ehrenstein, “The yin and yang of regulatory T cells and inflammation in RA,” Nature Reviews Rheumatology, vol. 6, no. 10, pp. 572–577, 2010. View at Google Scholar
  60. H. Dumond, N. Presle, B. Terlain et al., “Evidence for a key role of leptin in osteoarthritis,” Arthritis and Rheumatism, vol. 48, no. 11, pp. 3118–3129, 2003. View at Publisher · View at Google Scholar · View at Scopus
  61. N. Presle, P. Pottie, H. Dumond et al., “Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production,” Osteoarthritis and Cartilage, vol. 14, no. 7, pp. 690–695, 2006. View at Publisher · View at Google Scholar · View at Scopus
  62. J. H. Ku, C. K. Lee, B. S. Joo et al., “Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis,” Clinical Rheumatology, vol. 28, no. 12, pp. 1431–1435, 2009. View at Publisher · View at Google Scholar · View at Scopus
  63. T. Simopoulou, K. N. Malizos, D. Iliopoulos et al., “Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism,” Osteoarthritis and Cartilage, vol. 15, no. 8, pp. 872–883, 2007. View at Publisher · View at Google Scholar · View at Scopus
  64. T. M. Griffin, J. L. Huebner, V. B. Kraus, and F. Guilak, “Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis,” Arthritis and Rheumatism, vol. 60, no. 10, pp. 2935–2944, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. R. Gomez, M. Scotece, J. Conde et al., “Adiponectin and leptin increase IL-8 production in human chondrocytes,” Annals of the Rheumatic Diseases, vol. 70, no. 11, pp. 2052–2054, 2011. View at Google Scholar
  66. M. Otero, R. Lago, F. Lago, J. J. Reino, and O. Gualillo, “Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1,” Arthritis Research & Therapy, vol. 7, no. 3, pp. R581–R591, 2005. View at Google Scholar · View at Scopus
  67. E. Moilanen, K. Vuolteenaho, A. Koskinen et al., “Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage-mediator role of NO in leptin-induced PGE2 IL-6, and IL-8 production,” Mediators of Inflammation, vol. 2009, Article ID 345838, 10 pages, 2009. View at Publisher · View at Google Scholar · View at Scopus
  68. M. S. Mutabaruka, M. Aoulad Aissa, A. Delalandre, M. Lavigne, and D. Lajeunesse, “Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression,” Arthritis Research and Therapy, vol. 12, no. 1, article R20, 2010. View at Publisher · View at Google Scholar · View at Scopus
  69. A. Garcia-Gonzalez, L. Gonzalez-Lopez, I. C. Valera-Gonzalez et al., “Serum leptin levels in women with systemic lupus erythematosus,” Rheumatology International, vol. 22, no. 4, pp. 138–141, 2002. View at Publisher · View at Google Scholar · View at Scopus
  70. K. E. Sada, Y. Yamasaki, M. Maruyama et al., “Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus,” Journal of Rheumatology, vol. 33, no. 8, pp. 1545–1552, 2006. View at Google Scholar · View at Scopus
  71. A. S. E. Elwakkad, R. N. Said, S. I. Muhammad, M. T. Saleh, and A. Elhamshary, “Role for leptin and prolactin in human juvenile rheumatic diseases,” Pakistan Journal of Biological Sciences, vol. 10, no. 12, pp. 1984–1989, 2007. View at Google Scholar · View at Scopus
  72. M. Vadacca, D. Margiotta, A. Rigon et al., “Adipokines and systemic lupus erythematosus: relationship with metabolic syndrome and cardiovascular disease risk factors,” Journal of Rheumatology, vol. 36, no. 2, pp. 295–297, 2009. View at Publisher · View at Google Scholar · View at Scopus
  73. C. P. Chung, A. G. Long, J. F. Solus et al., “Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis,” Lupus, vol. 18, no. 9, pp. 799–806, 2009. View at Publisher · View at Google Scholar · View at Scopus
  74. B. H. Hahn, E. V. Lourenço, M. McMahon et al., “Pro-inflammatory high-density lipoproteins and atherosclerosis are induced in lupus-prone mice by a high-fat diet and leptin,” Lupus, vol. 19, no. 8, pp. 913–917, 2010. View at Publisher · View at Google Scholar · View at Scopus
  75. J. B. De Sanctis, M. Zabaleta, N. E. Bianco, J. V. Garmendia, and L. Rivas, “Serum adipokine levels in patients with systemic lupus erythematosus,” Autoimmunity, vol. 42, no. 4, pp. 272–274, 2009. View at Publisher · View at Google Scholar · View at Scopus
  76. M. Wislowska, M. Rok, K. Stepien et al., “Serum leptin in systemic lupus erythematosus,” Rheumatology International, vol. 28, no. 5, pp. 467–473, 2008. View at Google Scholar
  77. H. Hulejova, A. Levitova, M. Kuklova et al., “No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis,” Clinical Rheumatology, vol. 31, no. 1, pp. 67–71, 2012. View at Google Scholar
  78. E. Toussirot, G. Streit, N. U. Nguyen et al., “Adipose tissue, serum adipokines, and ghrelin in patients with ankylosing spondylitis,” Metabolism, vol. 56, no. 10, pp. 1383–1389, 2007. View at Publisher · View at Google Scholar · View at Scopus
  79. I. Sari, T. Demir, L. D. Kozaci et al., “Body composition, insulin, and leptin levels in patients with ankylosing spondylitis,” Clinical Rheumatology, vol. 26, no. 9, pp. 1427–1432, 2007. View at Publisher · View at Google Scholar · View at Scopus
  80. M. C. Park, S. W. Lee, S. T. Choi, Y. B. Park, and S. K. Lee, “Serum leptin levels correlate with interleukin-6 levels and disease activity in patients with ankylosing spondylitis,” Scandinavian Journal of Rheumatology, vol. 36, no. 2, pp. 101–106, 2007. View at Publisher · View at Google Scholar · View at Scopus
  81. M. C. Park, S. J. Chung, Y. B. Park, and S. K. Lee, “Pro-inflammatory effect of leptin on peripheral blood mononuclear cells of patients with ankylosing spondylitis,” Joint Bone Spine, vol. 76, no. 2, pp. 170–175, 2009. View at Publisher · View at Google Scholar · View at Scopus
  82. T. Kadowaki and T. Yamauchi, “Adiponectin and adiponectin receptors,” Endocrine Reviews, vol. 26, no. 3, pp. 439–451, 2005. View at Publisher · View at Google Scholar · View at Scopus
  83. D. K. Oh, T. Ciaraldi, and R. R. Henry, “Adiponectin in health and disease,” Diabetes, Obesity and Metabolism, vol. 9, no. 3, pp. 282–289, 2007. View at Google Scholar
  84. J. P. Whitehead, A. A. Richards, I. J. Hickman, G. A. Macdonald, and J. B. Prins, “Adiponectin—a key adipokine in the metabolic syndrome,” Diabetes, Obesity and Metabolism, vol. 8, no. 3, pp. 264–280, 2006. View at Publisher · View at Google Scholar · View at Scopus
  85. N. Maeda, M. Takahashi, T. Funahashi et al., “PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein,” Diabetes, vol. 50, no. 9, pp. 2094–2099, 2001. View at Google Scholar · View at Scopus
  86. T. Yamauchi, Y. Nio, T. Maki et al., “Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions,” Nature Medicine, vol. 13, no. 3, pp. 332–339, 2007. View at Publisher · View at Google Scholar · View at Scopus
  87. M. Stumvoll, O. Tschritter, A. Fritsche et al., “Association of the T-G polymorphism in adiponectin (Exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes,” Diabetes, vol. 51, no. 1, pp. 37–41, 2002. View at Google Scholar · View at Scopus
  88. W. Zhu, K. K. Y. Cheng, P. M. Vanhoutte, K. S. L. Lam, and A. Xu, “Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention,” Clinical Science, vol. 114, no. 5-6, pp. 361–374, 2008. View at Publisher · View at Google Scholar · View at Scopus
  89. Z. V. Wang and P. E. Scherer, “Adiponectin, cardiovascular function, and hypertension,” Hypertension, vol. 51, no. 1, pp. 8–14, 2008. View at Publisher · View at Google Scholar · View at Scopus
  90. W. S. Chow, B. M. Y. Cheung, A. W. K. Tso et al., “Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study,” Hypertension, vol. 49, no. 6, pp. 1455–1461, 2007. View at Publisher · View at Google Scholar · View at Scopus
  91. C. Tsioufis, K. Dimitriadis, M. Selima et al., “Low-grade inflammation and hypoadiponectinaemia have an additive detrimental effect on aortic stiffness in essential hypertensive patients,” European Heart Journal, vol. 28, no. 9, pp. 1162–1169, 2007. View at Publisher · View at Google Scholar · View at Scopus
  92. Y. Iwashima, T. Katsuya, K. Ishikawa et al., “Hypoadiponectinemia is an independent risk factor for hypertension,” Hypertension, vol. 43, no. 6, pp. 1318–1323, 2004. View at Publisher · View at Google Scholar · View at Scopus
  93. K. L. Ong, C. Q. Jiang, B. Liu et al., “Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese,” Clinical Endocrinology, vol. 74, no. 2, pp. 206–213, 2010. View at Google Scholar
  94. M. E. Trujillo and P. E. Scherer, “Adipose tissue-derived factors: impact on health and disease,” Endocrine Reviews, vol. 27, no. 7, pp. 762–778, 2006. View at Google Scholar
  95. T. A. Hopkins, N. Ouchi, R. Shibata, and K. Walsh, “Adiponectin actions in the cardiovascular system,” Cardiovascular Research, vol. 74, no. 1, pp. 11–18, 2007. View at Publisher · View at Google Scholar · View at Scopus
  96. M. Matsuda, I. Shimomura, M. Sata et al., “Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis,” Journal of Biological Chemistry, vol. 277, no. 40, pp. 37487–37491, 2002. View at Publisher · View at Google Scholar · View at Scopus
  97. Y. Wang, K. S. L. Lam, J. Y. Xu et al., “Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner,” Journal of Biological Chemistry, vol. 280, no. 18, pp. 18341–18347, 2005. View at Publisher · View at Google Scholar · View at Scopus
  98. Y. Motobayashi, Y. Izawa-Ishizawa, K. Ishizawa et al., “Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells,” Hypertension Research, vol. 32, no. 3, pp. 188–193, 2009. View at Publisher · View at Google Scholar · View at Scopus
  99. N. Ouchi, S. Kihara, Y. Arita et al., “Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages,” Circulation, vol. 103, no. 8, pp. 1057–1063, 2001. View at Google Scholar · View at Scopus
  100. K. Tsubakio-Yamamoto, F. Matsuura, M. Koseki et al., “Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages,” Biochemical and Biophysical Research Communications, vol. 375, no. 3, pp. 390–394, 2008. View at Publisher · View at Google Scholar · View at Scopus
  101. C. Tsatsanis, V. Zacharioudaki, A. Androulidaki et al., “Adiponectin induces TNF-α and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli,” Biochemical and Biophysical Research Communications, vol. 335, no. 4, pp. 1254–1263, 2005. View at Publisher · View at Google Scholar · View at Scopus
  102. R. Ouedraogo, X. Wu, S. Q. Xu et al., “Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway,” Diabetes, vol. 55, no. 6, pp. 1840–1846, 2006. View at Publisher · View at Google Scholar · View at Scopus
  103. H. Motoshima, X. Wu, K. Mahadev, and B. J. Goldstein, “Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL,” Biochemical and Biophysical Research Communications, vol. 315, no. 2, pp. 264–271, 2004. View at Publisher · View at Google Scholar · View at Scopus
  104. J. E. Kim, S. E. Song, Y. W. Kim et al., “Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase,” Journal of Endocrinology, vol. 207, no. 1, pp. 35–44, 2010. View at Publisher · View at Google Scholar · View at Scopus
  105. B. J. Goldstein, R. G. Scalia, and X. L. Ma, “Protective vascular and myocardial effects of adiponectin,” Nature Clinical Practice Cardiovascular Medicine, vol. 6, no. 1, pp. 27–35, 2009. View at Google Scholar
  106. L. Tao, E. Gao, X. Jiao et al., “Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress,” Circulation, vol. 115, no. 11, pp. 1408–1416, 2007. View at Publisher · View at Google Scholar · View at Scopus
  107. T. Pischon, C. J. Girman, G. S. Hotamisligil, N. Rifai, F. B. Hu, and E. B. Rimm, “Plasma adiponectin levels and risk of myocardial infarction in men,” Journal of the American Medical Association, vol. 291, no. 14, pp. 1730–1737, 2004. View at Publisher · View at Google Scholar · View at Scopus
  108. M. B. Schulze, I. Shai, E. B. Rimm, T. Li, N. Rifai, and F. B. Hu, “Adiponectin and future coronary heart disease events among men with type 2 diabetes,” Diabetes, vol. 54, no. 2, pp. 534–539, 2005. View at Publisher · View at Google Scholar · View at Scopus
  109. R. Wolk, P. Berger, R. J. Lennon, E. S. Brilakis, D. E. Davison, and V. K. Somers, “Association between plasma adiponectin levels and unstable coronary syndromes,” European Heart Journal, vol. 28, no. 3, pp. 292–298, 2007. View at Publisher · View at Google Scholar · View at Scopus
  110. A. Schäffler, A. Ehling, E. Neumann et al., “Adipocytokines in synovial fluid,” Journal of the American Medical Association, vol. 290, no. 13, pp. 1709–1710, 2003. View at Publisher · View at Google Scholar · View at Scopus
  111. M. Ozgen, S. S. Koca, N. Dagli, M. Balin, B. Ustundag, and A. Isik, “Serum adiponectin and vaspin levels in rheumatoid arthritis,” Archives of Medical Research, vol. 41, no. 6, pp. 457–463, 2010. View at Publisher · View at Google Scholar · View at Scopus
  112. Y. H. Rho, J. Solus, T. Sokka et al., “Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis,” Arthritis and Rheumatism, vol. 60, no. 7, pp. 1906–1914, 2009. View at Publisher · View at Google Scholar · View at Scopus
  113. A. M. El-Barbary, M. S. Hussein, E. M. Rageh, H. E. Hamouda, A. A. Wagih, and R. G. Ismail, “Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis,” Journal of Rheumatology, vol. 38, no. 2, pp. 229–235, 2011. View at Publisher · View at Google Scholar · View at Scopus
  114. L. Šenolt, K. Pavelka, D. Housa, and M. Haluzík, “Increased adiponectin is negatively linked to the local inflammatory process in patients with rheumatoid arthritis,” Cytokine, vol. 35, no. 5-6, pp. 247–252, 2006. View at Publisher · View at Google Scholar · View at Scopus
  115. W. Tan, F. Wang, M. Zhang, D. Guo, Q. Zhang, and S. He, “High adiponectin and adiponectin receptor 1 expression in synovial fluids and synovial tissues of patients with rheumatoid arthritis,” Seminars in Arthritis and Rheumatism, vol. 38, no. 6, pp. 420–427, 2009. View at Publisher · View at Google Scholar · View at Scopus
  116. M. A. Gonzalez-Gay, J. Llorca, M. T. Garcia-Unzueta et al., “High-grade inflammation, circulating adiponectin concentrations and cardiovascular risk factors in severe rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 26, no. 4, pp. 596–603, 2008. View at Google Scholar · View at Scopus
  117. C. Gonzalez-Juanatey, J. Llorca, J. Martin, and M. A. Gonzalez-Gay, “Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis,” Seminars in Arthritis and Rheumatism, vol. 38, no. 5, pp. 366–371, 2009. View at Publisher · View at Google Scholar · View at Scopus
  118. M. A. Gonzalez-Gay, C. Gonzalez-Juanatey, L. Rodriguez-Rodriguez, J. A. Miranda-Filloy, J. Martin, and J. Llorca, “Lack of association between adipokines and ghrelin and carotid intima-media thickness in patients with severe rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 29, no. 2, pp. 358–359, 2011. View at Google Scholar · View at Scopus
  119. L. Rodríguez-Rodríguez, M. García-Bermúdez, C. González-Juanatey et al., “Lack of association between ADIPOQ rs266729 and ADIPOQ rs1501299 polymorphisms and cardiovascular disease in rheumatoid arthritis patients,” Tissue Antigens, vol. 77, no. 1, pp. 74–78, 2011. View at Publisher · View at Google Scholar · View at Scopus
  120. N. Kusunoki, K. Kitahara, F. Kojima et al., “Adiponectin stimulates prostaglandin E2 production in rheumatoid arthritis synovial fibroblasts,” Arthritis and Rheumatism, vol. 62, no. 6, pp. 1641–1649, 2010. View at Publisher · View at Google Scholar · View at Scopus
  121. K. Kitahara, N. Kusunoki, T. Kakiuchi, T. Suguro, and S. Kawai, “Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts,” Biochemical and Biophysical Research Communications, vol. 378, no. 2, pp. 218–223, 2009. View at Publisher · View at Google Scholar · View at Scopus
  122. A. Ehling, A. Schäffler, H. Herfarth et al., “The potential of adiponectin in driving arthritis,” Journal of Immunology, vol. 176, no. 7, pp. 4468–4478, 2006. View at Google Scholar · View at Scopus
  123. R. Lago, R. Gomez, M. Otero et al., “A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes,” Osteoarthritis and Cartilage, vol. 16, no. 9, pp. 1101–1109, 2008. View at Publisher · View at Google Scholar · View at Scopus
  124. Y. A. Lee, H. M. Choi, S. H. Lee et al., “Synergy between adiponectin and interleukin-1b on the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in fibroblast-like synoviocytes,” Experimental and Molecular Medicine. In press.
  125. A. Koskinen, S. Juslin, R. Nieminen et al., “Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways,” Arthritis Research & Therapy, vol. 13, no. 6, p. R184, 2011. View at Google Scholar
  126. K. W. Frommer, B. Zimmermann, F. M. P. Meier et al., “Adiponectin-mediated changes in effector cells involved in the pathophysiology of rheumatoid arthritis,” Arthritis and Rheumatism, vol. 62, no. 10, pp. 2886–2899, 2010. View at Publisher · View at Google Scholar · View at Scopus
  127. K. W. Frommer, A. Schaffler, C. Buchler et al., “Adiponectin isoforms: a potential therapeutic target in rheumatoid arthritis?” Annals of the Rheumatic Diseases. In press. View at Publisher · View at Google Scholar
  128. M. Al, L. Ng, P. Tyrrell, J. Bargman, T. Bradley, and E. Silverman, “A dipokines as novel biomarkers in paediatric systemic lupus erythematosus,” Rheumatology, vol. 48, no. 5, pp. 497–501, 2009. View at Publisher · View at Google Scholar · View at Scopus
  129. M. Vadacca, E. M. Zardi, D. Margiotta et al., “Leptin, adiponectin and vascular stiffness parameters in women with systemic lupus erythematosus,” Internal and Emergency Medicine. In press. View at Publisher · View at Google Scholar
  130. B. H. Rovin, H. Song, L. A. Hebert et al., “Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus,” Kidney International, vol. 68, no. 4, pp. 1825–1833, 2005. View at Publisher · View at Google Scholar · View at Scopus
  131. T. Aprahamian, R. G. Bonegio, C. Richez et al., “The peroxisome proliferator-activated receptor γ agonist rosiglitazone ameliorates murine lupus by induction of adiponectin,” Journal of Immunology, vol. 182, no. 1, pp. 340–346, 2009. View at Google Scholar · View at Scopus
  132. M. McMahon, B. J. Skaggs, L. Sahakian et al., “High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids,” Annals of the Rheumatic Diseases, vol. 70, no. 9, pp. 1619–1624, 2011. View at Publisher · View at Google Scholar · View at Scopus
  133. S. Katsiougiannis, E. K. Kapsogeorgou, M. N. Manoussakis, and F. N. Skopouli, “Salivary gland epithelial cells: a new source of the immunoregulatory hormone adiponectin,” Arthritis and Rheumatism, vol. 54, no. 7, pp. 2295–2299, 2006. View at Publisher · View at Google Scholar · View at Scopus
  134. S. Katsiougiannis, R. Tenta, and F. N. Skopouli, “Activation of AMP-activated protein kinase by adiponectin rescues salivary gland epithelial cells from spontaneous and interferon-γ-induced apoptosis,” Arthritis and Rheumatism, vol. 62, no. 2, pp. 414–419, 2010. View at Publisher · View at Google Scholar · View at Scopus
  135. B. Samal, Y. Sun, G. Stearns, C. Xie, S. Suggs, and I. McNiece, “Cloning and characterization of the cDNA encoding a novel human pre-B- cell colony-enhancing factor,” Molecular and Cellular Biology, vol. 14, no. 2, pp. 1431–1437, 1994. View at Google Scholar · View at Scopus
  136. A. Fukuhara, M. Matsuda, M. Nishizawa et al., “Visfatin: a protein secreted by visceral fat that Mimics the effects of insulin,” Science, vol. 307, no. 5708, pp. 426–430, 2005. View at Publisher · View at Google Scholar · View at Scopus
  137. D. Friebe, M. Neef, J. Kratzsch et al., “Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans,” Diabetologia, vol. 54, no. 5, pp. 1200–1211, 2011. View at Publisher · View at Google Scholar · View at Scopus
  138. V. Catalán, J. Gómez-Ambrosi, A. Rodríguez et al., “Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 21, no. 4, pp. 245–253, 2011. View at Publisher · View at Google Scholar · View at Scopus
  139. C. A. Curat, V. Wegner, C. Sengenès et al., “Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin,” Diabetologia, vol. 49, no. 4, pp. 744–747, 2006. View at Publisher · View at Google Scholar · View at Scopus
  140. A. Fukuhara, M. Matsuda, M. Nishizawa et al., “Retraction,” Science, vol. 318, no. 5850, p. 565, 2007. View at Google Scholar · View at Scopus
  141. S. H. Jia, Y. Li, J. Parodo et al., “Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis,” Journal of Clinical Investigation, vol. 113, no. 9, pp. 1318–1327, 2004. View at Publisher · View at Google Scholar · View at Scopus
  142. M. Zhong, H. W. Tan, H. P. Gong, S. F. Wang, Y. Zhang, and W. Zhang, “Increased serum visfatin in patients with metabolic syndrome and carotid atherosclerosis,” Clinical Endocrinology, vol. 69, no. 6, pp. 878–884, 2008. View at Publisher · View at Google Scholar · View at Scopus
  143. T. B. Dahl, A. Yndestad, M. Skjelland et al., “Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization,” Circulation, vol. 115, no. 8, pp. 972–980, 2007. View at Publisher · View at Google Scholar · View at Scopus
  144. S. G. Spiroglou, C. G. Kostopoulos, J. N. Varakis, and H. H. Papadaki, “Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis,” Journal of Atherosclerosis and Thrombosis, vol. 17, no. 2, pp. 115–130, 2010. View at Google Scholar · View at Scopus
  145. T. D. Filippatos and V. Tsimihodimos, “Increased plasma visfatin concentration is a marker of an atherogenic metabolic profile,” Nutrition, Metabolism & Cardiovascular Diseases. In press. View at Publisher · View at Google Scholar
  146. R. Adya, B. K. Tan, J. Chen, and H. S. Randeva, “Pre-B cell colony enhancing factor (PBEF)/visfatin induces secretion of MCP-1 in human endothelial cells: role in visfatin-induced angiogenesis,” Atherosclerosis, vol. 205, no. 1, pp. 113–119, 2009. View at Publisher · View at Google Scholar · View at Scopus
  147. F. Lovren, Y. Pan, P. C. Shukla et al., “Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis,” American Journal of Physiology, vol. 296, no. 6, pp. E1440–E1449, 2009. View at Publisher · View at Google Scholar · View at Scopus
  148. L. Šenolt, O. Kryštůfková, H. Hulejová et al., “The level of serum visfatin (PBEF) is associated with total number of B cells in patients with rheumatoid arthritis and decreases following B cell depletion therapy,” Cytokine, vol. 55, no. 1, pp. 116–121, 2011. View at Publisher · View at Google Scholar · View at Scopus
  149. F. Brentano, O. Schorr, C. Ospelt et al., “Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities,” Arthritis and Rheumatism, vol. 56, no. 9, pp. 2829–2839, 2007. View at Publisher · View at Google Scholar · View at Scopus
  150. I. R. Klein-Wieringa, M. P. van der Linden, R. Knevel et al., “Baseline serum adipokine levels predict radiographic progression in early rheumatoid arthritis,” Arthritis & Rheumatism, vol. 63, no. 9, pp. 2567–2574, 2011. View at Google Scholar
  151. M. A. Gonzalez-Gay, T. R. Vazquez-Rodriguez, M. T. Garcia-Unzueta et al., “Visfatin is not associated with inflammation or metabolic syndrome in patients with severe rheumatoid arthritis undergoing anti-TNF-α therapy,” Clinical and Experimental Rheumatology, vol. 28, no. 1, pp. 56–62, 2010. View at Google Scholar · View at Scopus
  152. A. R. Moschen, A. Kaser, B. Enrich et al., “Visfatin, an adipocytokine with proinflammatory and immunomodulating properties,” Journal of Immunology, vol. 178, no. 3, pp. 1748–1758, 2007. View at Google Scholar · View at Scopus
  153. N. Busso, M. Karababa, M. Nobile et al., “Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD,” PLoS ONE, vol. 3, no. 5, Article ID e2267, 2008. View at Publisher · View at Google Scholar · View at Scopus
  154. M. Garcia-Bermudez and C. Gonzalez-Juanatey, “Lack of association of NAMPT rs9770242 and rs59744560 polymorphisms with disease susceptibility and cardiovascular risk in patients with rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 29, no. 4, pp. 681–688, 2011. View at Google Scholar
  155. M. Gosset, F. Berenbaum, C. Salvat et al., “Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis,” Arthritis and Rheumatism, vol. 58, no. 5, pp. 1399–1409, 2008. View at Publisher · View at Google Scholar · View at Scopus
  156. Y. Duan, D. Hao, M. Li et al., “Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis,” Rheumatology International, vol. 32, no. 4, pp. 985–990, 2012. View at Google Scholar
  157. M. Ozgen, S. S. Koca, K. Aksoy, N. Dagli, B. Ustundag, and A. Isik, “Visfatin levels and intima-media thicknesses in rheumatic diseases,” Clinical Rheumatology, vol. 30, no. 6, pp. 757–763, 2011. View at Publisher · View at Google Scholar · View at Scopus
  158. C. M. Steppan, S. T. Bailey, S. Bhat et al., “The hormone resistin links obesity to diabetes,” Nature, vol. 409, no. 6818, pp. 307–312, 2001. View at Publisher · View at Google Scholar · View at Scopus
  159. M. Degawa-Yamauchi, J. E. Bovenkerk, B. E. Juliar et al., “Serum resistin (FIZZ3) protein is increased in obese humans,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 11, pp. 5452–5455, 2003. View at Publisher · View at Google Scholar · View at Scopus
  160. P. G. McTernan, C. L. McTernan, R. Chetty et al., “Increased resistin gene and protein expression in human abdominal adipose tissue,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 5, pp. 2407–2410, 2002. View at Publisher · View at Google Scholar · View at Scopus
  161. C. M. Steppan, E. J. Brown, C. M. Wright et al., “A family of tissue-specific resistin-like molecules,” Proceedings of the National Academy of Sciences of the United State, vol. 98, no. 2, pp. 502–506, 2001. View at Google Scholar
  162. L. K. Heilbronn, J. Rood, L. Janderova et al., “Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 4, pp. 1844–1848, 2004. View at Publisher · View at Google Scholar · View at Scopus
  163. J. H. Lee, J. L. Chan, N. Yiannakouris et al., “Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 10, pp. 4848–4856, 2003. View at Publisher · View at Google Scholar · View at Scopus
  164. M. S. Jamaluddin, S. M. Weakley, Q. Yao et al., “Resistin: functional roles and therapeutic considerations for cardiovascular disease,” British Journal of Pharmacology, vol. 165, no. 3, pp. 622–632, 2012. View at Google Scholar
  165. C. Espinola-Klein, T. Gori, S. Blankenberg, and T. Munzel, “Inflammatory markers and cardiovascular risk in the metabolic syndrome,” Frontiers in Bioscience, vol. 16, no. 5, pp. 1663–1674, 2011. View at Publisher · View at Google Scholar · View at Scopus
  166. H. Wang, D. Y. Chen, J. Cao, Z. Y. He, B. P. Zhu, and M. Long, “High serum resistin level may be an indicator of the severity of coronary disease in acute coronary syndrome,” Chinese Medical Sciences Journal, vol. 24, no. 3, pp. 161–166, 2009. View at Publisher · View at Google Scholar · View at Scopus
  167. W. L. Hu, S. B. Qiao, Q. Hou, and J. S. Yuan, “Plasma resistin is increased in patients with unstable angina,” Chinese Medical Journal, vol. 120, no. 10, pp. 871–875, 2007. View at Google Scholar · View at Scopus
  168. S. Chu, W. Ding, K. Li, Y. Pang, and C. Tang, “Plasma resistin associated with myocardium injury in patients with acute coronary syndrome,” Circulation Journal, vol. 72, no. 8, pp. 1249–1253, 2008. View at Publisher · View at Google Scholar · View at Scopus
  169. H. S. Jung, K. H. Park, Y. M. Cho et al., “Resistin is secreted from macrophages in atheromas and promotes atherosclerosis,” Cardiovascular Research, vol. 69, no. 1, pp. 76–85, 2006. View at Publisher · View at Google Scholar · View at Scopus
  170. S. Langheim, L. Dreas, L. Veschini et al., “Increased expression and secretion of resistin in epicardial adipose tissue of patients with acute coronary syndrome,” American Journal of Physiology, vol. 298, no. 3, pp. H746–H753, 2010. View at Publisher · View at Google Scholar · View at Scopus
  171. M. Melone, L. Wilsie, O. Palyha et al., “Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin/kexin type 9,” Journal of the American College of Cardiology, vol. 59, no. 19, pp. 1697–1705, 2012. View at Google Scholar
  172. H. Forsblad d'Elia, R. Pullerits, H. Carlsten, and M. Bokarewa, “Resistin in serum is associated with higher levels of IL-1Ra in post-menopausal women with rheumatoid arthritis,” Rheumatology, vol. 47, no. 7, pp. 1082–1087, 2008. View at Publisher · View at Google Scholar · View at Scopus
  173. L. Šenolt, D. Housa, Z. Vernerová et al., “Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum,” Annals of the Rheumatic Diseases, vol. 66, no. 4, pp. 458–463, 2007. View at Publisher · View at Google Scholar · View at Scopus
  174. L. Rodriguez-Rodriguez, M. Garcia-Bermudez, C. Gonzalez-Juanatey et al., “Lack of association between RETN rs1862513 polymorphism and cardiovascular disease in rheumatoid arthritis patients,” Clinical and Experimental Rheumatology, vol. 29, no. 1, pp. 19–25, 2011. View at Google Scholar · View at Scopus
  175. M. Bokarewa, I. Nagaev, L. Dahlberg, U. Smith, and A. Tarkowski, “Resistin, an adipokine with potent proinflammatory properties,” Journal of Immunology, vol. 174, no. 9, pp. 5789–5795, 2005. View at Google Scholar · View at Scopus
  176. E. A. Bostrom, M. Svensson, S. Andersson et al., “Resistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis,” Arthritis & Rheumatism, vol. 63, no. 10, pp. 2894–2904, 2011. View at Google Scholar
  177. M. A. Gonzalez-Gay, M. T. Garcia-Unzueta, C. Gonzalez-Juanatey et al., “Anti-TNF-α therapy modulates resistin in patients with rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 26, no. 2, pp. 311–316, 2008. View at Google Scholar · View at Scopus
  178. Y. M. Son, S. M. Ahn, G. R. Kim et al., “Resistin enhances the expansion of regulatory T cells through modulation of dendritic cells,” BMC Immunology, vol. 11, article 33, 2010. View at Publisher · View at Google Scholar · View at Scopus
  179. R. Krysiak, G. Handzlik-Orlik, and B. Okopien, “The role of adipokines in connective tissue diseases,” European Journal of Nutrition. In press. View at Publisher · View at Google Scholar
  180. K. Almehed, H. F. d'Elia, M. Bokarewa, and H. Carlsten, “Role of resistin as a marker of inflammation in systemic lupus erythematosus,” Arthritis Research and Therapy, vol. 10, no. 1, article R15, 2008. View at Publisher · View at Google Scholar · View at Scopus
  181. H. Kocabas, V. Kocabas, S. Buyukbas, M. A. Melikoglu, I. Sezer, and B. Butun, “The serum levels of resistin in ankylosing spondylitis patients: a pilot study,” Rheumatology International, vol. 32, no. 3, pp. 699–702, 2012. View at Publisher · View at Google Scholar · View at Scopus