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Mediators of Inflammation
Volume 2012, Article ID 136020, 7 pages
http://dx.doi.org/10.1155/2012/136020
Research Article

Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model

1Department of Trauma and Orthopaedic Surgery, Cologne Merheim Medical Center, Faculty of Health-School of Medicine, Witten/Herdecke University, Ostmerheimer Straße 200, 51109 Cologne, Germany
2Department of Trauma, Neurosurgery, Hannover Medical School, 30623 Hannover, Germany
3Department of Traumatology, Hannover Medical School, 30623 Hannover, Germany
4Department of Anaesthesiology, Nordstadt Hospital Hannover, 30167 Hannover, Germany
5International Neuroscience Institute Hannover, Department of Neurosurgery, 30625 Hannover, Germany
6Institute of Experimental Traumatology, University of Technology-Munich, 81675 München, Germany

Received 13 October 2011; Accepted 6 December 2011

Academic Editor: Frank Hildebrand

Copyright © 2012 C. Probst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. J. L. Murray and A. D. Lopez, “Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study,” Lancet, vol. 349, no. 9064, pp. 1498–1504, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Frink, M. van Griensven, P. Kobbe et al., “IL-6 predicts organ dysfunction and mortality in patients with multiple injuries,” Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, vol. 17, p. 49, 2009. View at Google Scholar
  3. C. Probst, B. A. Zelle, N. A. Sittaro, R. Lohse, C. Krettek, and H. C. Pape, “Late death after multiple severe trauma: when does it occur and what are the causes?” The Journal of Trauma, vol. 66, no. 4, pp. 1212–1217, 2009. View at Google Scholar · View at Scopus
  4. M. Bardenheuer, U. Obertacke, C. Waydhas, and D. Nast-Kolb, “Epidemiology of the severe multiple trauma—a prospective registration of preclinical and clinical supply,” Unfallchirurg, vol. 103, no. 5, pp. 355–363, 2000. View at Publisher · View at Google Scholar
  5. D. Nast-Kolb, M. Aufmkolk, S. Rucholtz, U. Obertacke, and C. Waydhas, “Multiple organ failure still a major cause of morbidity but not mortality in blunt multiple trauma,” Journal of Trauma, vol. 51, no. 5, pp. 835–842, 2001. View at Google Scholar · View at Scopus
  6. G. Regel, M. Grotz, T. Weltner, J. A. Sturm, and H. Tscherne, “Pattern of organ failure following severe trauma,” World Journal of Surgery, vol. 20, no. 4, pp. 422–429, 1996. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Smail, A. Messiah, A. Edouard et al., “Role of systemic inflammatory response syndrome and infection in the occurrence of early multiple organ dysfunction syndrome following severe trauma,” Intensive Care Medicine, vol. 21, no. 10, pp. 813–816, 1995. View at Publisher · View at Google Scholar · View at Scopus
  8. R. M. Durham, J. J. Moran, J. E. Mazuski, M. J. Shapiro, A. E. Baue, and L. M. Flint, “Multiple organ failure in trauma patients,” Journal of Trauma, vol. 55, no. 4, pp. 608–616, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Hildebrand, P. Giannoudis, M. Van Griensven et al., “Secondary effects of femoral instrumentation on pulmonary physiology in a standardised sheep model: what is the effect of lung contusion and reaming?” Injury, vol. 36, no. 4, pp. 544–555, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. H. C. Pape, “Effects of changing strategies of fracture fixation on immunologic changes and systemic complications after multiple trauma: damage control orthopedic surgery,” Journal of Orthopaedic Research, vol. 26, no. 11, pp. 1478–1484, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. P. V. Giannoudis, V. T. Veysi, H. C. Pape, C. Krettek, and M. R. Smith, “When should we operate on major fractures in patients with severe head injuries?” American Journal of Surgery, vol. 183, no. 3, pp. 261–267, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Tsukamoto and H. C. Pape, “Animal models for trauma research: what are the options?” Shock, vol. 31, no. 1, pp. 3–10, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Marklund and L. Hillered, “Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?” British Journal of Pharmacology, vol. 164, no. 4, pp. 1207–1229, 2011. View at Publisher · View at Google Scholar
  14. M. Frink, H. Andruszkow, C. Zeckey, C. Krettek, and F. Hildebrand, “Experimental trauma models: an update,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 797383, 15 pages, 2011. View at Publisher · View at Google Scholar
  15. B. D. Semple, N. Bye, M. Rancan, J. M. Ziebell, and M. C. Morganti-Kossmann, “Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice,” Journal of Cerebral Blood Flow and Metabolism, vol. 30, no. 4, pp. 769–782, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Lloyd, K. Somera-Molina, L. J. Van Eldik, D. M. Watterson, and M. S. Wainwright, “Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury,” Journal of Neuroinflammation, vol. 5, article no. 28, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Shapira, E. Shohami, A. Sidi, D. Soffer, S. Freeman, and S. Cotev, “Experimental closed head injury in rats: mechanical, pathophysiologic, and neurologic properties,” Critical Care Medicine, vol. 16, no. 3, pp. 258–265, 1988. View at Google Scholar · View at Scopus
  18. Y. Chen, S. Constantini, V. Trembovler, M. Weinstock, and E. Shohami, “An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits,” Journal of Neurotrauma, vol. 13, no. 10, pp. 557–568, 1996. View at Google Scholar · View at Scopus
  19. M. Van Griensven, M. Kuzu, M. Breddin et al., “Polymicrobial sepsis induces organ changes due to granulocyte adhesion in a murine two hit model of trauma,” Experimental and Toxicologic Pathology, vol. 54, no. 3, pp. 203–209, 2002. View at Google Scholar · View at Scopus
  20. J. Meixensberger and K. Roosen, “Clinical and pathophysiological significance of severe neurotrauma in polytraumatized patients,” Langenbeck's Archives of Surgery, vol. 383, no. 3-4, pp. 214–219, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. T. A. Gennarelli, H. R. Champion, W. S. Copes, and W. J. Sacco, “Comparison of mortality, morbidity, and severity of 59,713 head injured patients with 114,447 patients with extracranial injuries,” Journal of Trauma, vol. 37, no. 6, pp. 962–968, 1994. View at Google Scholar · View at Scopus
  22. M. Maegele, D. Engel, B. Bouillon et al., “Incidence and outcome of traumatic brain injury in an urban area in western Europe over 10 years,” European Surgical Research, vol. 39, no. 6, pp. 372–379, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Ayala, M. M. Perrin, D. R. Meldrum, W. Ertel, and I. H. Chaudry, “Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin,” Cytokine, vol. 2, no. 3, pp. 170–174, 1990. View at Google Scholar · View at Scopus
  24. J. Jiang, K. Tian, and H. Chen, “Changes of plasma cytokines in patients with severe trauma and their relationship with organ damage,” Zhonghua wai ke za zhi [Chinese journal of surgery], vol. 35, no. 7, pp. 406–407, 1997. View at Google Scholar · View at Scopus
  25. S. A. Ross, M. I. Halliday, G. C. Campbell, D. P. Byrnes, and B. J. Rowlands, “The presence of tumour necrosis factor in CSF and plasma after severe head injury,” British Journal of Neurosurgery, vol. 8, no. 4, pp. 419–425, 1994. View at Google Scholar · View at Scopus
  26. J. C. Goodman, C. S. Robertson, R. G. Grossman, and R. K. Narayan, “Elevation of tumor necrosis factor in head injury,” Journal of Neuroimmunology, vol. 30, no. 2-3, pp. 213–217, 1990. View at Google Scholar · View at Scopus
  27. E. Shohami, R. Bass, D. Wallach, A. Yamin, and R. Gallily, “Inhibition of tumor necrosis factor alpha (TNFα) activity in rat brain is associated with cerebroprotection after closed head injury,” Journal of Cerebral Blood Flow and Metabolism, vol. 16, no. 3, pp. 378–384, 1996. View at Google Scholar · View at Scopus
  28. S. M. Knoblach, L. Fan, and A. I. Faden, “Early neuronal expression of tumor necrosis factor-α after experimental brain injury contributes to neurological impairment,” Journal of Neuroimmunology, vol. 95, no. 1-2, pp. 115–125, 1999. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Maegele, P. Riess, S. Sauerland et al., “Characterization of a new rat model of experimental combined neurotrauma,” Shock, vol. 23, no. 5, pp. 476–481, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Van Griensven, C. Krettek, and H. C. Pape, “Immune reactions after trauma,” European Journal of Trauma, vol. 29, no. 4, pp. 181–192, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. J. W. Berman, M. P. Guida, J. Warren, J. Amat, and C. F. Brosnan, “Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat,” Journal of Immunology, vol. 156, no. 8, pp. 3017–3023, 1996. View at Google Scholar · View at Scopus
  32. K. A. Harkness, J. D. Sussman, G. A. B. Davies-Jones, J. Greenwood, and M. N. Woodroofe, “Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells,” Journal of Neuroimmunology, vol. 142, no. 1-2, pp. 1–9, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. I. Thibeault, N. Laflamme, and S. Rivest, “Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating lps and proinflammatory cytokines,” Journal of Comparative Neurology, vol. 434, no. 4, pp. 461–477, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. M. M. Aguilar, F. D. Battistella, J. T. Owings, S. A. Olson, and K. MacColl, “Posttraumatic lymphocyte response: a comparison between peripheral blood T cells and tissue T cells,” Journal of Trauma, vol. 45, no. 1, pp. 14–18, 1998. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Lundblad, P. Ekstrøm, and K. E. Giercksky, “Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats,” Shock, vol. 3, no. 3, pp. 210–215, 1995. View at Google Scholar · View at Scopus
  36. M. T. Coccia, K. Waxman, M. H. Soliman, G. Tominaga, and L. Pinderski, “Pentoxifylline improves survival following hemorrhagic shock,” Critical Care Medicine, vol. 17, no. 1, pp. 36–38, 1989. View at Google Scholar · View at Scopus
  37. M. Maegele, S. Sauerland, B. Bouillon et al., “Differential immunoresponses following experimental traumatic brain injury, bone fracture and “two-hit”-combined neurotrauma,” Inflammation Research, vol. 56, no. 8, pp. 318–323, 2007. View at Publisher · View at Google Scholar · View at Scopus