Involvement of the Ubiquitin-Proteasome System in the Formation of Experimental Postsurgical Peritoneal Adhesions

Figure 5

Levels (ng/mg tissue) of TNF-alpha, p50, p65, and IL-6 within the tissues from rats during peritoneal adhesions development at time 0, 5, and 10 days from the peritoneal surgery. The rats were treated or not with bortezomib by intravenous injection (0.05 mg/kg) given 1 hour before surgery, and a second injection was given 1 hour after the surgical procedure (total dose of 0.1 mg/kg). The differences from day 0 are considered with *𝑃<0.01, and the differences from the control group at the same day are considered as °𝑃<0.01.

(a)

(b)