Activation of Human Neutrophils by the Anti-Inflammatory Mediator Esenbeckia leiocarpa Leads to Atypical Apoptosis
Figure 7
CHE induces apoptosis in a p38-independent mechanism. Cells (10 × 106 cells/mL) were incubated with (+) or without (−) CHE or the antiapoptotic cytokine GM-CSF (GM, 65 ng/mL) in the presence (+) or absence (−) of the p38 inhibitor (SB203580) or the MEK-1/MEK-2 inhibitor (PD98059) for 22 h. Apoptosis was evaluated by cytology. Results are means ± SEM (). * versus Ctrl (left column, absence of CHE and inhibitors) and # versus GM by Student’s t-test.
