Mediators of Inflammation / 2012 / Article / Tab 2

Research Article

Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome

Table 2

Specific activities of proteasomes isolated from healthy controls and ARDS patients.

Chtr (pmol/min μg)Try (pmol/min μg)PGPH (pmol/min μg)Chtr/PGPHPGPH/TryChtr/Try

Healthy controls24.310.738.222.9511.233.3
ARDS patients9.870.689.930.9914.614.5

Proteolytic activities of purified 20S proteasome from BAL supernatant of healthy controls and of ARDS patients, as measured with specific proteasomal fluorogenic substrates. BAL supernatants were pooled from 5 healthy subjects and from 5 ARDS patients, respectively. The ratio of enzyme activities differs between ARDS patients and healthy subjects, suggesting a rearrangement of proteasomal subunit composition.
PGPH: peptidyl-glutamyl peptide-hydrolysing activity; Try: trypsin-like activity; Chtr: chymotrypsin-like activity.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.