Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome

Table 3

Characteristics of BAL in ARDS and healthy subjects.

	ARDS patients (𝑛=28)	Healthy subjects (𝑛=10)	𝑃 value
Proteasome concentration in BAL supernatant [ng/mL]	971 ± 1116	59 ± 25	<0.001
Proteasome concentration in plasma [ng/mL]	2855 ± 2422	348 ± 126	<0.001
Suc-LLVY-AMC proteasome activity in BAL supernatant [pkat/mg]	3.1±6.2	7.3±3.7	<0.001
BZ-VGR-AMC proteasome activity in BAL supernatant [pkat/mg]	1.8±2.5	5.7±3.2	<0.001
Suc-LLE-AMC proteasome activity in BAL supernatant [pkat/mg]	0.8±1.1	2 ± 1.2	0.002
Total protein concentration in BAL supernatant [mg/mL]	3.8±6.4	0.06±0.01	<0.001
Albumin concentration in BAL supernatant [mg/mL]	1.5 ± 3	0.03±0.01	0.0011
LDH in BAL supernatant [U/L]	342 ± 779	28 ± 9.7	0.024
LDH in plasma [U/L]	821 ± 1104	184 ± 53	<0.001
Cell count in cell pellet [10^6/mL]	330 ± 994	8.6±2.5	0.007
Macrophages [%]	29.1±27.4	92.6±3.4	<0.001
Neutrophile granulocytes [%]	65.1±27.7	2.8±2.5	<0.001
Lymphocytes [%]	5.1±7.9	6.3±2.9	0.056

Data are means ± SD.