Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2012 (2012), Article ID 214581, 5 pages
http://dx.doi.org/10.1155/2012/214581
Clinical Study

Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia

1Division of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, Turkey
2Fırat Üniversitesi Hastanesi Çocuk Sağ. ve Hast. Anabilim Dalı Elazığ, Turkey
3Department of Medical Pathology, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, Turkey

Received 12 August 2011; Accepted 10 January 2012

Academic Editor: Helieh S. Oz

Copyright © 2012 Yaşar Doğan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups. Results. The study included 64 cases (average: 1 0 . 2 ± 0 . 4 years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were 4 5 . 5 ± 4 . 7 % and 1 . 9 ± 0 . 1 , respectively. Hp-negative cases showed significantly different values of 1 7 . 8 ± 4 . 5 % and 1 . 3 ± 0 . 2 , respectively. Hemoglobin and serum ferritin values of Hp-positive cases were 1 2 . 7 ± 0 . 2 g /dL and 3 2 . 5 ± 2 n g /mL, but these were comparable with Hp-negative cases ( 1 2 . 6 ± 0 . 1 g /dL and 3 0 . 7 ± 4 . 4 n g /mL). Conclusions. Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.