Review Article
Eicosanoids and Respiratory Viral Infection: Coordinators of Inflammation and Potential Therapeutic Targets
Figure 1
Synthesis of PGE2 and the leukotrienes. cPLA2—cytosolic phospholipase A2, AA—arachidonic acid, FLAP—5-lipoxygenase activating protein, 5-LO—5-lipoxygenase, LTA4—leukotriene A4, LTA4H—leukotriene A4 hydrolase, LTB4— leukotriene B4, BLT1 and BLT2—B leukotriene receptor 1 and 2, LTC4S—leukotriene C4 synthase, LTC4—leukotriene C4, γ-GT-γ-glutamyl transpeptidase, γ-GL-γ-glutamyl leukotrienease, LTD4—leukotriene D4, DiP—dipeptidase, LTE4—leukotriene E4, cysLTs—cysteinyl leukotrienes, cysLT1 and cysLT2—cysteinyl leukotriene receptor 1 and 2, COX-1 and COX-2—cyclooxygenase 1 and 2, PGH2—prostaglandin H2, mPGES-1 and -2—microsomal prostaglandin E synthase-1 and -2, PGE2—prostaglandin E2, EP1-4—E prostanoid receptors 1–4.
