Eicosanoids and Respiratory Viral Infection: Coordinators of Inflammation and Potential Therapeutic Targets

Table 1

Effects of PGE₂ and leukotrienes on immune function.

	PGE2	LTB4	cysLTs
Neutrophils	Inhibits neutrophil chemotaxis, phagocytosis, and bacterial killing	Promotes neutrophil chemotaxis, ROS generation, and survival	Induces NO generation in neutrophils
Macrophages	Inhibits AM phagocytosis, ROS generation, and bacterial killing	Enhances AM phagocytosis	Enhance AM phagocytosis
T cells	Promotes Th17 differentiation	Induces T cell recruitment	Enhances Th2 response
B cells/Antibody production	Promotes isotype switching to IgE and IgG1	Induces activation, differentiation, and proliferation of B cells	Upregulate IgE and IgG1 production by B cells
Dendritic Cells	Varies	Promotes DC migration	Promotes DC migration
Cytokines	Suppresses IFN-γ and IL-12 production	Enhances TNF-α production	Enhances IL-5, IL-13, and eotaxin expression
	Enhances IL-10 and IL-6 production
Antimicrobial Peptides	Inhibits AMP production by epithelial cells	Induces AMP production by neutrophils	Unknown