Review Article
Eicosanoids and Respiratory Viral Infection: Coordinators of Inflammation and Potential Therapeutic Targets
Table 1
Effects of PGE2 and leukotrienes on immune function.
| | PGE2 | LTB4 | cysLTs |
| Neutrophils | Inhibits neutrophil chemotaxis, phagocytosis, and bacterial killing | Promotes neutrophil chemotaxis, ROS generation, and survival | Induces NO generation in neutrophils |
| Macrophages | Inhibits AM phagocytosis, ROS generation, and bacterial killing | Enhances AM phagocytosis | Enhance AM phagocytosis |
| T cells | Promotes Th17 differentiation | Induces T cell recruitment | Enhances Th2 response |
| B cells/Antibody production | Promotes isotype switching to IgE and IgG1 | Induces activation, differentiation, and proliferation of B cells | Upregulate IgE and IgG1 production by B cells |
| Dendritic Cells | Varies | Promotes DC migration | Promotes DC migration |
| Cytokines | Suppresses IFN-γ and IL-12 production | Enhances TNF-α production | Enhances IL-5, IL-13, and eotaxin expression | Enhances IL-10 and IL-6 production | | |
| Antimicrobial Peptides | Inhibits AMP production by epithelial cells | Induces AMP production by neutrophils | Unknown |
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