Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals
Table 4
Clinical characteristics of obese subjects according to anti-apoA-1 IgG status.
Obese Patients ()
Anti-apoA-1 IgG positive patients
Anti-apoA-1 IgG negative patients
P value
()
()
Age, years
47.5 (39–59)
43 (34.5–54)
0.23
Male gender; % (n)
67 (4)
57 (21)
1
Total Cholesterol, mg/dL
156.0 (124.8–175.5)
198.9 (175.5–230.1)
0.008
LDL Cholesterol, mg/dL
87.2 (70.2–113.1)
127.9 (102.6–150.2)
0.01
HDL Cholesterol, mg/dL
45.2 (43.7–46.0)
40.9 (37.4–46.8)
0.24
Triglycerides, mg/dL
62.7 (43.6–117.5)
124.6 (96.1–189.0)
0.01
Glucose, mg/dL
90.5 (86.5–108.1)
100.9 (91.9–108.1)
0.23
Insulin, mU/L
5.2 (5.2–8.3)
12.7 (7.3–21.6)
0.11
HOMA
1.22 (1.11–1.93)
3.59 (1.77–5.56)
0.15
HbA1C, %
5.4 (5.3–5.5)
5.4 (5.1–5.7)
0.92
Hs-CRP, mg/L
4.0 (1.5–13.1)
5.2 (2.9–8.5)
0.69
Framingham Risk Score (FRS)
2.5 (0.9–5)
2.0 (0.9–4)
0.80
BMI, kg/m2
32.2 (31.6–32.8)
42.0 (34.1–45.3)
0.08
Waist
116 (114–120)
119 (111–124)
0.86
Waist to hip ratio
0.98 (0.89–1.03)
0.96 (0.91–0.98)
0.53
Total fat, Kg
34.1 (27.3–39.9)
45.4 (32.9–58.6)
0.12
Percent of body fat
34.9 (24.8–40.5)
38.7 (30.1–47.9)
0.17
*Agatston score
2.05 (0–23.2; 0–38.3)
0(0-0;0–77.1)
0.003
Subjects with significant coronary lesion; % (n)
67 (4)
5 (2)
0.001
Myocardial blood flow (MBF);
(mL/min/g):
At rest
0.76 (0.55–0.79)
0.79 (0.66–0.93)
0.16
Normalized at rest
1.01(0.89–1.20)
0.92 (0.84–1.13)
0.42
During CPT
0.80 (0.71–1.13)
0.87 (0.76–0.95)
0.65
ΔMBF (CPT-rest)
0.16 (0.07–0.34)
0.09 (0.03–0.16)
0.16
Normalized during CPT
0.92 (0.81–1.21)
0.76 (0.67–0.88)
0.05
During hyperemia
2.12 (1.40–2.61)
2.11 (1.78–2.37)
0.85
Myocardial flow reserve; (mL/min/g)
2.92 (2.38–3.30)
2.62 (2.13–3.20)
0.62
MBF hyperemia/NMBF rest
2.14 (1.41–2.18)
2.13 (1.81–2.67)
0.56
Coronary vascular resistance
(CVR); (mmHg/mL/mL/g)
At rest
113.3 (90.3–132.1)
112.7 (97.1–134.3)
0.89
During CPT
119.7 (81.1–140)
128.2 (110.0–139.4)
0.49
ΔCVR (CPT-rest)
−3.25 (−9.17–7.95)
5.86 (−5.06–18.04)
0.59
In response to DP
40.6 (28.9–53.6)
42.8 (37.2–53.4)
0.17
Coronary endothelial dysfunction
ΔMBF to CPT < 0.3, % (n)
67 (4)
97 (36)
0.05
Values are median (Q1, Q3), at the exception of *represented as (Q1–Q3; and range). P values according to Mann-Whitney U test for continuous values and to exact bilateral Fischer test for proportions.
