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Mediators of Inflammation
Volume 2012, Article ID 257808, 8 pages
http://dx.doi.org/10.1155/2012/257808
Clinical Study

Evaluation of Serum Adipokines in Peripheral Arterial Occlusive Disease

Surgical Clinic II, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, No. 4-6 Clinicilor Street, 400006 Cluj-Napoca, Romania

Received 12 October 2011; Revised 6 January 2012; Accepted 20 January 2012

Academic Editor: Oreste Gualillo

Copyright © 2012 Claudia D. Gherman and Aurel I. Mironiuc. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. Out study aimed to assess the serum levels of adipokines in patients with peripheral arterial occlusive disease (PAOD) caused by atherosclerosis. Methods. Serum samples were obtained from 221 patients. One hundred and forty patients, (26 females and 114 males) met the inclusion criteria and were assigned into the case group. Eighty one patients (17 females and 64 males), were included in the control group. Circulating plasma levels of adiponectin, leptin, resistin, and TNF-α were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results. Significant lower levels of adiponectin were present ( 𝑃 = 0 . 0 0 6 1 ) in PAOD patients ( 2 3 8 0 . 2 3 ± 1 6 3 4 . 4 2  pg/mL) compared to the control group ( 3 0 6 5 . 0 6 ± 1 9 0 1 . 2  pg/mL). The mean value of leptin ( 2 8 4 4 . 4 2 ± 3 3 0 1 . 0 8  pg/mL) and resistin (2047.81±3301.08 pg/mL) patients included in the PAOD group was higher, as compared to the control group. Statistically significant difference was found between the two groups for leptin ( 𝑃 = 0 . 0 3 3 2 ) and for resistin ( 𝑃 = 0 . 0 3 5 2 ). No statistically significant difference for TNF-α was found between the two groups ( 𝑃 > 0 . 0 5 ). Conclusion. The markers of inflammation secreted by the adipose tissue (adiponectin, leptin, resistin) showed significant differences in patients from the case group (with PAOD) compared to the control group.