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Mediators of Inflammation
Volume 2012, Article ID 307189, 5 pages
Research Article

Mast Cells and Histamine: Do They Influence Placental Vascular Network and Development in Preeclampsia?

1Chair and Department of General and Experimental Pathology, Medical University of Warsaw, Ul. Krakowskie Przedmiescie 26/28, 00-927 Warsaw, Poland
2Department of Gynecological Oncology, National Institute of Oncology, Ul. Wawelska 15, 02-000 Warsaw, Poland
3Department of Anesthesiology and Intensive Care, Military Institute of Health, Ul. Szaserów 128, 04-141 Warsaw, Poland

Received 16 February 2012; Revised 27 April 2012; Accepted 27 April 2012

Academic Editor: Felipe Vadillo-Ortega

Copyright © 2012 Grzegorz Szewczyk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The physiological course of pregnancy is closely related to adequate development of the placenta. Shallow invasion of trophoblast as well as decreased development of the placental vascular network are both common features of preeclampsia. To better understand the proangiogenic features of mast cells, in this study we aim to identify the potential relationship between the distribution of mast cells within the placenta and vascular network development. Material and Methods. Placentas from preeclampsia-complicated pregnancies ( 𝑛 = 1 1 ) and from physiological pregnancies ( 𝑛 = 1 1 ) were acquired after cesarean section. The concentration of histamine was measured, and immunohistochemical staining for mast cell tryptase was performed. Morphometric analysis was then performed. Results. We noticed significant differences between the examined groups. Notably, in the preeclampsia group compared to the control group, we observed a higher mean histamine concentration, higher mast cell density (MCD), lower mean mast cell (MMCA) and lower vascular/extravascular (V/EVT) index. In physiological pregnancies, a positive correlation was observed between the histamine concentration and V/VEVT index as well as MCD and the V/VEVT index. In contrast, a negative correlation was observed between MMCA and the V/EVT index in physiological pregnancies. Conclusions. Based on the data from our study, we suggest that a differential distribution of mast cells and corresponding changes in the concentration of histamine are involved in the defective placental vascularization seen in preeclamptic placentas.