Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators
Figure 2
Heat shock proteins in early human tendinopathy. (a) Biopsies from subscapularis tendon revealed grade 1-2 pathological changes (mucoid degeneration, increased neovascularisation) in keeping with early tendinopathy. This was a chance finding when using this tissue as an internal control. This has subsequently allowed us to investigate alarmin molecule in early stressed tendon tissue. (b) These biopsies subsequently showed a significant increase in heat shock protein mRNA in tendon pathology. The bar graph illustrates the relative expression of apoptosis and HSP genes in human tendon samples. The data are displayed as the mean ± SEM, for supraspinatus and matched subscapularis, for control group (*; **). (c) The immunohistochemistry of heat shock protein HSP27 and HSP70 is shown in torn human subscapularis tendon (a) and in torn human supraspinatus tendon (b) (magnification ×200).
