Anti-Inflammatory and Antinociceptive Effects of Salbutamol on Acute and Chronic Models of Inflammation in Rats: Involvement of an Antioxidant Mechanism

Table 1

Effects of salbutamol and indomethacin on carrageenan-induced inflammatory paw edema in rats.

Drugs	Increase in inflammatory paw volume (mL)				Anti-inflammatory effect
	1st h	2nd h	3rd h	4th h	1st h	2nd h	3rd h	4th h
SAL-1	0.14 ± 0.02*	0.28 ± 0.13*	0.27 ± 0.05*	0.27 ± 0.03*	43.9	43.4	44	37.5
SAL-2	0.13 ± 0.03*	0.26 ± 0.05*	0.25 ± 0.04*	0.22 ± 0.03*	44.6	48.1	48.5	48.8
IND-25	0.19 ± 0.01*	0.29 ± 0.06*	0.28 ± 0.02*	0.22 ± 0.02*	27.7	40.3	42.7	48.4
Control	0.25 ± 0.03	0.49 ± 0.06	0.49 ± 0.02	0.43 ± 0.02	—	—	—	—

SAL-1: salbutamol 1 mg/kg; SAL-2: salbutamol 2 mg/kg; IND: indomethacin 25 mg/kg. *Significant at 𝑃<0.05 when compared to control. (All groups received an intraplantar injection of 0.1 mL, 1% carrageenan.)