Mediators of Inflammation / 2012 / Article / Fig 2

Research Article

Low Dose Theophylline Showed an Inhibitory Effect on the Production of IL-6 and IL-8 in Primary Lung Fibroblast from Patients with COPD

Figure 2

Increased mRNA and protein levels of interleukin-8 (IL-8) in lung fibroblasts from COPD patients. (a) Real-time RT-PCR was adopted to evaluate the transcription levels of IL-8, and the relative expression was calculated based on the expression of GAPDH. ** 𝑃 = 0 . 0 0 2 , when compared to control group. (b) The relationship of IL-8 mRNA and FEV1. (c) The protein level of IL-8 of primary lung fibroblasts from subjects with COPD. ELISA was adopted to measure the concentration of IL-8 in the cell-free supernatants. *** 𝑃 < 0 . 0 0 1 , when compared to control group. (d) The relationship of IL-8 secretion.
492901.fig.002a
(a)
492901.fig.002b
(b)
492901.fig.002c
(c)
492901.fig.002d
(d)

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.