Low Dose Theophylline Showed an Inhibitory Effect on the Production of IL-6 and IL-8 in Primary Lung Fibroblast from Patients with COPD

Table 1

Clinical and demographic features of the subjects.

	COPD^†	Control^‡	𝑃 value
Gender (M/F)	5/5	5/3	NS
Age (yrs)	65.3±9.8	69.5±3.1	NS
Smoking history (pack-yrs)	43.0±17.7	30.0±10.0	NS
FEV1 (L)	1.35±0.26	2.20±0.33	<0.001
FEV1% pred	68.7±18.7	90.2±5.5	0.0128
FVC (L)	2.75±0.76	2.97±0.45	NS
FVC% pred	86.2±20.5	89.0±10.2	NS
FEV1/FVC%	57.4±8.8	79.3±9.4	<0.001

Data are presented as mean ± SD. COPD: chronic obstructive pulmonary disease; M: male; F: female; FEV1: forced expiratory volume in one second; % pred: % predicted; FVC: forced vital capacity; NS: nonsignificant. ^†Subjects having an FEV1/FVC < 70%. ^‡Subjects having an FEV1/FVC ≥ 70%.