Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders

<table><i>Correlations between clinical and serological variables</i>. (a) Negative correlation between nitric oxide (NO) levels and intima-media thickness (IMT) values in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients. <svg height="11.375" id="M38" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 60.662498 11.375" width="60.662498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><path d="M627 18l-10 -26q-79 6 -116 27t-69 76q-41 71 -71 138q-13 29 -27.5 39t-42.5 10h-46l-27 -145q-13 -74 -2.5 -88.5t78.5 -20.5l-6 -28h-271l5 28q66 6 82.5 21.5t30.5 87.5l71 387q12 66 2 78.5t-77 19.5l8 28h233q102 0 147 -29q65 -43 65 -129q0 -69 -45.5 -117
t-115.5 -72q40 -86 66 -133q39 -68 65 -101q28 -37 73 -51zM491 483q0 67 -33.5 101t-91.5 34q-35 0 -51 -10q-13 -8 -20 -48l-45 -245h49q71 0 113 28q79 52 79 140z" id="x1D445"></path></g><g transform="matrix(.017,-0,0,-.017,15.718,11.112)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,30.422,11.112)"><path d="M535 230h-483v50h483v-50z" id="x2212"></path></g><g transform="matrix(.017,-0,0,-.017,40.401,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,48.56,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,52.436,11.112)"><use xlink:href="#x33"></use></g>
</svg>, <svg height="11.375" id="M39" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.875 11.375" width="66.875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x33"></use></g><g transform="matrix(.017,-0,0,-.017,58.64,11.112)"><use xlink:href="#x33"></use></g>
</svg>. (b) Negative correlation between <i><i>β</i></i>-carotene levels and the onset of the disease (evaluated in terms of year in which the disease was diagnosed) in RA patients. <svg height="11.375" id="M40" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 68.824997 11.375" width="68.824997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D445"></use></g><g transform="matrix(.017,-0,0,-.017,15.718,11.112)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,30.422,11.112)"><use xlink:href="#x2212"></use></g><g transform="matrix(.017,-0,0,-.017,40.401,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,48.56,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,52.436,11.112)"><use xlink:href="#x36"></use></g><g transform="matrix(.017,-0,0,-.017,60.595,11.112)"><use xlink:href="#x32"></use></g>
</svg>, <svg height="11.375" id="M41" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.875 11.375" width="66.875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x32"></use></g><g transform="matrix(.017,-0,0,-.017,58.64,11.112)"><use xlink:href="#x38"></use></g>
</svg>.</table>

Mediators of Inflammation

fig5

Figure 5

Figure 5: Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders 