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Mediators of Inflammation
Volume 2012 (2012), Article ID 512926, 18 pages
http://dx.doi.org/10.1155/2012/512926
Review Article

The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses

1Department of Genetic Engineering, Sungkyunkwan University, Suwon 446-746, Republic of Korea
2Research Institute and Hospital, National Cancer Center, Goyang 410-769, Republic of Korea

Received 12 August 2012; Accepted 28 September 2012

Academic Editor: Marja Ojaniemi

Copyright © 2012 Se Eun Byeon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [95 citations]

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  • Christel Verollet, Anne Gallois, Romain Dacquin, Claire Lastrucci, Subramanya N. M. Pandruvada, Nathalie Ortega, Renaud Poincloux, Annie Behar, Celine Cougoule, Clifford Lowell, Talal Al Saati, Pierre Jurdic, and Isabelle Maridonneau-Parini, “Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors,” Faseb Journal, vol. 27, no. 9, pp. 3608–3618, 2013. View at Publisher · View at Google Scholar
  • Ju Young Yoon, Hye Yoon Jeong, Shi Hyoung Kim, Han Gyung Kim, Gyeongsug Nam, Jin Pyo Kim, Deok Hyo Yoon, Hyunsik Hwang, Tae Woong Kimc, Sungyoul Hong, and Jae Youl Cho, “Methanol extract of Evodia lepta displays Syk/Src-targeted anti-inflammatory activity,” Journal of Ethnopharmacology, 2013. View at Publisher · View at Google Scholar
  • Ji Hye Kim, Yong Gyu Lee, Seungwan Yoo, Jueun Oh, Deok Jeong, Woo Keun Song, Byong Chul Yoo, Man Hee Rhee, Jongsun Park, Sang-hoon Cha, Sungyoul Hong, and Jae Youl Cho, “Involvement of Src and the actin cytoskeleton in the antitumorigenic action of adenosine dialdehyde,” Biochemical Pharmacology, vol. 85, no. 8, pp. 1042–1056, 2013. View at Publisher · View at Google Scholar
  • Wojciech Witkowski, and Bruno Verhasselt, “Contributions of HIV-1 Nef to immune dysregulation in HIV-infected patients: a therapeutic target?,” Expert Opinion on Therapeutic Targets, vol. 17, no. 11, pp. 1345–1356, 2013. View at Publisher · View at Google Scholar
  • Woo Seok Yang, Deok Jeong, Young-Su Yi, Jae Gwang Park, Hyohyun Seo, Sang Hyun Moh, and Sungyoul Hong, “IRAK1/4-Targeted Anti-Inflammatory Action of Caffeic Acid,” Mediators of Inflammation, 2013. View at Publisher · View at Google Scholar
  • Jae Youl Cho, and Mi-Yeon Kim, “20S-dihydroprotopanaxadiol, a ginsenoside derivative, boosts innate immune responses of monocytes and macrophages,” Journal Of Ginseng Research, vol. 37, no. 3, pp. 293–299, 2013. View at Publisher · View at Google Scholar
  • Mi-Yeon Kim, and Jae Youl Cho, “20S-dihydroprotopanaxatriol modulates functional activation of monocytes and macrophages,” Journal Of Ginseng Research, vol. 37, no. 3, pp. 300–307, 2013. View at Publisher · View at Google Scholar
  • Hyung Jun Noh, Ju Young Yoon, Geum Sook Kim, Seung Eun Lee, Dae Young Lee, Je Hun Choi, Seung Yu Kim, Ki Sung Kang, Jae Youl Cho, and Ki Hyun Kim, “ Benzyl alcohol derivatives from the mushroom Hericium erinaceum attenuate LPS-stimulated inflammatory response through the regulation of NF- κ B and AP-1 activity ,” Immunopharmacology and Immunotoxicology, pp. 1–6, 2014. View at Publisher · View at Google Scholar
  • Ruchi Roy, Dinesh Kumar, Akanksha Sharma, Parul Gupta, Bhushan P. Chaudhari, Anurag Tripathi, Mukul Das, and Premendra D. Dwivedi, “ZnO nanoparticles induced adjuvant effect via Toll-like receptors and Src signaling in Balb/c mice,” Toxicology Letters, 2014. View at Publisher · View at Google Scholar
  • Xiaoxing You, Liangzhuan Liu, Yanhua Zeng, Ranhui Li, Jun He, Xiaohua Ma, Chuanhao Jiang, Cuiming Zhu, Liesong Chen, Minjun Yu, Guangli Ou, and Yimou Wu, “Macrophage-Activating Lipopeptide-2 Requires Mal and PI3K for Efficient Induction of Heme Oxygenase-1,” Plos One, vol. 9, no. 7, 2014. View at Publisher · View at Google Scholar
  • Yanyan Yang, Jongsung Lee, Man Hee Rhee, Tao Yu, Kwang-Soo Baek, Nak Yoon Sung, Yong Kim, Keejung Yoon, Ji Hye Kim, Yi-Seong Kwak, Sungyoul Hong, Jong-Hoon Kim, and Jae Youl Cho, “Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions,” Journal of Ginseng Research, 2014. View at Publisher · View at Google Scholar
  • Eunji Kim, Kee Dong Yoon, Woo-Shin Lee, Woo Seok Yang, Shi Hyoung Kim, Nak Yoon Sung, Kwang-Soo Baek, Yong Kim, Khin Myo Htwe, Young-Dong Kim, Sungyoul Hong, Jong-Hoon Kim, and Jae Youl Cho, “Syk/Src-targeted anti-inflammatory activity of Codariocalyx motorius ethanolic extract,” Journal of Ethnopharmacology, 2014. View at Publisher · View at Google Scholar
  • Yanyan Yang, Woo Seok Yang, Tao Yu, Gi-Ho Sung, Kye Won Park, Keejung Yoon, Young-Jin Son, Hyunsik Hwang, Yi-Seong Kwak, Chang-Muk Lee, Man Hee Rhee, Jong-Hoon Kim, and Jae Youl Cho, “ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract,” Journal of Ethnopharmacology, 2014. View at Publisher · View at Google Scholar
  • To Thi Mai Dung, Seung Cheol Kim, Byong Chul Yoo, Gi-Ho Sung, Woo Seok Yang, Han Gyung Kim, Jae Gwang Park, Man Hee Rhee, Kye Won Park, Keejung Yoon, Yunmi Lee, Sungyoul Hong, Jong-Hoon Kim, and Jae Youl Cho, “(5-Hydroxy-4-oxo-4H-pyran-2-yl)methyl 6-hydroxynaphthalene-2-carboxylate, a kojic acid derivative, inhibits inflammatory mediator production via the suppression of Syk/Src and NF-κB activation,” International Immunopharmacology, 2014. View at Publisher · View at Google Scholar
  • Hye Yoon Jeong, Gi-Ho Sung, Ji Hye Kim, Ju Young Yoon, Yanyan Yang, Jae Gwang Park, Shi Hyoung Kim, Young-Su Yi, Woo Seok Yang, Deok Hyo Yoon, Tae Woong Kim, Jong-Hoon Kim, and Jae Youl Cho, “Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity,” Journal of Ethnopharmacology, vol. 151, no. 2, pp. 960–969, 2014. View at Publisher · View at Google Scholar
  • Woo Seok Yang, Deok Jeong, Young-Su Yi, Byoung-Hee Lee, Tae Woong Kim, Khin Myo Htwe, Young-Dong Kim, Kee Dong Yoon, Sungyoul Hong, Woo-Shin Lee, and Jae Youl Cho, “Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1,” Journal of Ethnopharmacology, vol. 151, no. 3, pp. 1165–1174, 2014. View at Publisher · View at Google Scholar
  • Deok Jeong, Young-Su Yi, Gi-Ho Sung, Woo Seok Yang, Jae Gwang Park, Keejung Yoon, Deok Hyo Yoon, Changsik Song, Yunmi Lee, Jong-Hoon Kim, Man Hee Rhee, Tae Woong Kim, and Jae Youl Cho, “Anti-inflammatory activities and mechanisms of Artemisia asiatica ethanol extract,” Journal of Ethnopharmacology, 2014. View at Publisher · View at Google Scholar
  • Wei Guo, Ping Ye, Hong Yu, Zhonghao Liu, Pishan Yang, and Neil Hunter, “CD24 activates the NLRP3 inflammasome through c-Src kinase activity in a model of the lining epithelium of inflamed periodontal tissues,” Immunity, Inflammation and Disease, 2014. View at Publisher · View at Google Scholar
  • Sebastien Tauzin, Taylor W. Starnes, Francisco Barros Becker, Pui-ying Lam, and Anna Huttenlocher, “Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration,” Journal Of Cell Biology, vol. 207, no. 5, pp. 589–598, 2014. View at Publisher · View at Google Scholar
  • To Thi Mai Dung, Jongsung Lee, Eunji Kim, Byong Chul Yoo, Van Thai Ha, Yong Kim, Deok Hyo Yoon, Sungyoul Hong, Kwang-Soo Baek, Nak Yoon Sung, Tae Woong Kim, Jong-Hoon Kim, and Jae Youl Cho, “ Anti-inflammatory Activities of Gouania leptostachya Methanol Extract and its Constituent Resveratrol ,” Phytotherapy Research, 2014. View at Publisher · View at Google Scholar
  • Muhammad Jahangir Hossen, Kwang-Soo Baek, Eunji Kim, Woo Seok Yang, Deok Jeong, Jun Ho Kim, Dae-Hyuk Kweon, Deok Hyo Yoon, Tae Woong Kim, Jong-Hoon Kim, and Jae Youl Cho, “In vivo and in vitro anti-inflammatory activities of Persicaria chinensis methanolic extract targeting Src/ Syk/NF-κB,” Journal of Ethnopharmacology, 2014. View at Publisher · View at Google Scholar
  • Kwang-Soo Baek, Yong Deog Hong, Yong Kim, Nak Yoon Sung, Sungjae Yang, Kyoung Min Lee, Joo Yong Park, Jun Seong Park, Ho Sik Rho, Song Seok Shin, and Jae Youl Cho, “Anti-inflammatory activity of AP-SF, a ginsenoside-enriched fraction, from Korean ginseng,” Journal of Ginseng Research, 2014. View at Publisher · View at Google Scholar
  • Li-Qian Ma, Chun-Shui Pan, Ning Yang, Yu-Ying Liu, Li Yan, Kai Sun, Xiao-Hong Wei, Ke He, Meng-Meng Xiao, Jing-Yu Fan, and Jing-Yan Han, “Posttreatment with Ma-Xing-Shi-Gan-Tang, a Chinese Medicine Formula, Ameliorates Lipopolysaccharide-Induced Lung Microvessel Hyperpermeability and Inflammatory Reaction in Rat,” Microcirculation, vol. 21, no. 7, pp. 649–663, 2014. View at Publisher · View at Google Scholar
  • Su Jin Lee, Cung Hoa Thien Quach, Kyung-Ho Jung, Tin-Young Paik, Jin Hee Lee, Jin Won Park, and Kyung-Han Lee, “Oxidized Low-Density Lipoprotein Stimulates Macrophage F-18-FDG Uptake via Hypoxia-Inducible Factor-1 alpha Activation Through Nox2-Dependent Reactive Oxygen Species Generation,” Journal of Nuclear Medicine, vol. 55, no. 10, pp. 1699–1705, 2014. View at Publisher · View at Google Scholar
  • Yanyan Yang, Woo Seok Yang, Tao Yu, Young-Su Yi, Jae Gwang Park, Deok Jeong, Ji Hye Kim, Jeong Su Oh, Keejung Yoon, Jong-Hoon Kim, and Jae Youl Cho, “Novel anti-inflammatory function of NSC95397 by the suppression of multiple kinases,” Biochemical Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Young-Su Yi, Young-Jin Son, Chongsuk Ryou, Gi-Ho Sung, Jong-Hoon Kim, and Jae Youl Cho, “Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses,” Mediators of Inflammation, vol. 2014, pp. 1–12, 2014. View at Publisher · View at Google Scholar
  • Eunji Kim, Woo Seok Yang, Ji Hye Kim, Jae Gwang Park, Han Gyung Kim, Jaeyoung Ko, Yong Deog Hong, Ho Sik Rho, Song Seok Shin, Gi-Ho Sung, and Jae Youl Cho, “Lancemaside A from Codonopsis lanceolata Modulates the Inflammatory Responses Mediated by Monocytes and Macrophages,” Mediators of Inflammation, vol. 2014, pp. 1–12, 2014. View at Publisher · View at Google Scholar
  • Han Gyung Kim, Woo Seok Yang, Gi-Ho Sung, Ji Hye Kim, Gwang-Soo Baek, Eunji Kim, Sungjae Yang, Yung Chul Park, Jae Mo Sung, Deok Hyo Yoon, Tae Woong Kim, Sungyoul Hong, Jong-Hoon Kim, and Jae Youl Cho, “ IKK β -Targeted Anti-Inflammatory Activities of a Butanol Fraction of Artificially Cultivated Cordyceps pruinosa Fruit Bodies ,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–12, 2014. View at Publisher · View at Google Scholar
  • Woo Seok Yang, Jaeyoung Ko, Eunji Kim, Ji Hye Kim, Jae Gwang Park, Nak Yoon Sung, Han Gyung Kim, Sungjae Yang, Ho Sik Rho, Yong Deog Hong, Song Seok Shin, and Jae Youl Cho, “ 21-O-Angeloyltheasapogenol E3, a Novel Triterpenoid Saponin from the Seeds of Tea Plants, Inhibits Macrophage-Mediated Inflammatory Responses in a NF- κ B-Dependent Manner ,” Mediators of Inflammation, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Tao Yu, Yong Jun Li, Ai Hong Bian, Hui Bin Zuo, Ti Wen Zhu, Sheng Xiang Ji, Fanming Kong, De Qing Yin, Chuan Bao Wang, Zi Fu Wang, Hong Qun Wang, Yanyan Yang, Byong Chul Yoo, and Jae Youl Cho, “The Regulatory Role of Activating Transcription Factor 2 in Inflammation,” Mediators of Inflammation, vol. 2014, pp. 1–10, 2014. View at Publisher · View at Google Scholar
  • Nak Yoon Sung, Mi-Yeon Kim, and Jae Youl Cho, “Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity,” Korean Journal Of Physiology & Pharmacology, vol. 19, no. 5, pp. 441–449, 2015. View at Publisher · View at Google Scholar
  • Jun Ho Kim, Mi-Yeon Kim, Jong-Hoon Kim, and Jae Youl Cho, “Fisetin suppresses macrophage-mediated inflammatory responses by blockade of Src and Syk,” Biomolecules and Therapeutics, vol. 23, no. 5, pp. 414–420, 2015. View at Publisher · View at Google Scholar
  • Kevin Wilhelmsen, Judith Hellman, Fengyun Xu, Katherine Farrar, Alphonso Tran, Samira Khakpour, Shirin Sundar, Arun Prakash, Jinhua Wang, and Nathanael S. Gray, “Extracellular signalregulated kinase 5 promotes acute cellular and systemic inflammation,” Science Signaling, vol. 8, no. 391, pp. ra86, 2015. View at Publisher · View at Google Scholar
  • Ha Van Thai, Eunji Kim, Seung Cheol Kim, Deok Jeong, Sungjae Yang, Kwang-Soo Baek, Yong Kim, Zubair Ahmed Ratan, Kee Dong Yoon, Jong-Hoon Kim, and Jae Youl Cho, “Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6,” Journal of Functional Foods, vol. 17, pp. 476–490, 2015. View at Publisher · View at Google Scholar
  • Quanchi Chen, Zifei Zhou, Liancheng Shan, Hui Zeng, Yingqi Hua, and Zhengdong Cai, “The importance of Src signaling in sarcoma,” Oncology Letters, vol. 10, no. 1, pp. 17–22, 2015. View at Publisher · View at Google Scholar
  • Shi Hyoung Kim, Jae Gwang Park, Gi-Ho Sung, Sungjae Yang, Woo Seok Yang, Eunji Kim, Jun Ho Kim, Van Thai Ha, Han Gyung Kim, Young-Su Yi, Ji Hye Kim, Kwang-Soo Baek, Nak Yoon Sung, Mi-nam Lee, Jong-Hoon Kim, and Jae Youl Cho, “Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain,” Molecular Nutrition & Food Research, 2015. View at Publisher · View at Google Scholar
  • Muhammad Jahangir Hossen, Sung Ho Jeon, Seung Cheol Kim, Ji Hye Kim, Deok Jeong, Nak Yoon Sung, Sungjae Yang, Kwang-Soo Baek, Jun Ho Kim, Deok Hyo Yoon, Won O. Song, Ki Dong Yoon, Sang-Ho Cho, Sukchan Lee, Jong-Hoon Kim, and Jae Youl Cho, “In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract,” Journal of Ethnopharmacology, 2015. View at Publisher · View at Google Scholar
  • Renato Socodato, Camila C. Portugal, Ivan Domith, Nadia A. Oliveira, Vivian S. M. Coreixas, Erick C. Loiola, Tania Martins, Ana Raquel Santiago, Roberto Paes-de-Carvalho, Antonio F. Ambrosio, and Joao B. Relvas, “c-Src Function is Necessary and Sufficient for Triggering Microglial Cell Activation,” Glia, vol. 63, no. 3, pp. 497–511, 2015. View at Publisher · View at Google Scholar
  • Hongqiao Zhang, and Henry Jay Formann, “4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1B,” Free Radical Biology And Medicine, vol. 89, pp. 701–707, 2015. View at Publisher · View at Google Scholar
  • Jose Miguel Cabral, Daniela Gracio, Patricio Soares-da-Silva, and Fernando Magro, “Short- and long-term regulation of intestinal Na+/H+ exchange by Toll-like receptors TLR4 and TLR5,” American Journal Of Physiology-Gastrointestinal And Liver Physiology, vol. 309, no. 8, pp. G703–G715, 2015. View at Publisher · View at Google Scholar
  • Arthur Weiss, Tanya S Freedman, Ying X Tan, Katarzyna M Skrzypczynska, Boryana N Manz, Frances V Sjaastad, Helen S Goodridge, and Clifford A Lowell, “LynA regulates an inflammation-sensitive signaling checkpoint in macrophages,” eLife, vol. 4, 2015. View at Publisher · View at Google Scholar
  • Yuanyuan Zhang, Minhui Sun, Yuwei Han, Kefeng Zhai, Youmei Tang, Xiaoying Qin, Zhengyu Cao, Boyang Yu, and Junping Kou, “The saponin DT-13 Attenuates Tumor Necrosis Factor-alpha-induced Vascular Inflammation Associated with Src/NF-kappa B/MAPK Pathway Modulation,” International Journal Of Biological Sciences, vol. 11, no. 8, pp. 970–981, 2015. View at Publisher · View at Google Scholar
  • Øystein Bruserud, Bjørn Tore Gjertsen, Håkon Reikvam, Karen-Marie Hagen, Amir Kadi, Frederic Pendino, Hanne Fredly, Jørn Skavland, Tuyen Thy Van Hoang, Annette K. Brenner, and Audrey Astori, “Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells-high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation,” Oncotarget, vol. 6, no. 5, pp. 2794–2811, 2015. View at Publisher · View at Google Scholar
  • Woo Seok Yang, Zubair Ahmed Ratan, Gihyeon Kim, Yunmi Lee, Mi-Yeon Kim, Jong-Hoon Kim, and Jae Youl Cho, “ 4-Isopropyl-2,6-bis(1-phenylethyl)aniline 1, an Analogue of KTH-13 Isolated from Cordyceps bassiana , Inhibits the NF- κ B-Mediated Inflammatory Response ,” Mediators of Inflammation, vol. 2015, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  • Woan Sean Tan, Palanisamy Arulselvan, Govindarajan Karthivashan, and Sharida Fakurazi, “ Moringa oleifera Flower Extract Suppresses the Activation of Inflammatory Mediators in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via NF- κ B Pathway ,” Mediators of Inflammation, vol. 2015, pp. 1–11, 2015. View at Publisher · View at Google Scholar
  • Young-Su Yi, Kwang-Soo Baek, Nak Yoon Sung, Muhammad Jahangir Hossen, Mi-nam Lee, Jong-Hoon Kim, Jae Youl Cho, Shi Hyoung Kim, Jae Gwang Park, Jongsung Lee, Woo Seok Yang, Gye Won Park, and Han Gyung Kim, “The Dietary Flavonoid Kaempferol Mediates Anti-Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets,” Mediators of Inflammation, vol. 2015, pp. 1–15, 2015. View at Publisher · View at Google Scholar
  • Young-Su Yi, Jae Youl Cho, and Daewon Kim, “Cerbera manghas methanol extract exerts anti-inflammatory activity by targeting c-Jun N-terminal kinase in the AP-1 pathway,” Journal of Ethnopharmacology, 2016. View at Publisher · View at Google Scholar
  • Süreyya Ölgen, “Design strategies, structures and molecular interactions of small molecule src inhibitors,” Anti-Cancer Agents in Medicinal Chemistry, vol. 16, no. 8, pp. 992–1002, 2016. View at Publisher · View at Google Scholar
  • Nak Yoon Sung, Seung Cheol Kim, Yun Hwan Kim, Gihyeon Kim, Yunmi Lee, Gi-Ho Sung, Ji Hye Kim, Woo Seok Yang, Mi Seon Kim, Kwang-Soo Baek, Jong-Hoon Kim, and Jae Youl Cho, “Anti-Proliferative and Pro-Apoptotic Activities of 4-Methyl-2,6-bis(1-phenylethyl)phenol in Cancer Cells,” Biomolecules & Therapeutics, vol. 24, no. 4, pp. 402–409, 2016. View at Publisher · View at Google Scholar
  • Woo Seok Yang, Young-Su Yi, Donghyun Kim, Min Ho Kim, Jae Gwang Park, Eunji Kim, Sang Yeol Lee, Keejung Yoon, Jong-Hoon Kim, Junseong Park, and Jae Youl Cho, “Nuclear factor kappa-B- and activator protein-1-mediated immunostimulatory activity of compound K in monocytes and macrophages,” Journal of Ginseng Research, 2016. View at Publisher · View at Google Scholar
  • M. Elena Rodríguez-Cabezas, Olga Genilloud, Julio Gálvez, Caridad Díaz, Mercedes De La Cruz, Jesús Martín, Ignacio Pérez-Victoria, Víctor González-Menéndez, Nuria De Pedro, José R. Tormo, José Pérez Del Palacio, Francesca Algieri, Alba Rodriguez-Nogales, Fernando Reyes, Francisca Vicente, and Frederick Annang, “High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries,” Journal of Biomolecular Screening, vol. 21, no. 6, pp. 567–578, 2016. View at Publisher · View at Google Scholar
  • Muhammad Jahangir Hossen, Jae Youl Cho, and Daewon Kim, “PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities,” Journal of Ethnopharmacology, 2016. View at Publisher · View at Google Scholar
  • Jae Park, Young-Jin Son, Mi-Yeon Kim, and Jae Cho, “Syk and IRAK1 Contribute to Immunopharmacological Activities of Anthraquinone-2-carboxlic Acid,” Molecules, vol. 21, no. 6, pp. 809, 2016. View at Publisher · View at Google Scholar
  • Shi Hyoung Kim, Jae Gwang Park, Yong Deog Hong, Eunji Kim, Kwang-Soo Baik, Deok Hyo Yoon, Sunggyu Kim, Mi-nam Lee, Ho Sik Rho, Song Seok Shin, and Jae Youl Cho, “Src/Syk/IRAK1-targeted anti-inflammatory action of Torreya nucifera butanol fraction in lipopolysaccharide-activated RAW264.7 cells,” Journal of Ethnopharmacology, 2016. View at Publisher · View at Google Scholar
  • Leif D. Nelin, Hilary A. White, Yi Jin, Jennifer K. Trittmann, Bernadette Chen, and Yusen Liu, “The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial c,” American Journal Of Physiology-Lung Cellular And Molecular Physiology, vol. 310, no. 9, pp. L880–L888, 2016. View at Publisher · View at Google Scholar
  • Gyun Jee Song, Myungsu Jung, Jong-Heon Kim, Hana Park, Md Habibur Rahman, Sheng Zhang, Zhong-Yin Zhang, Dong Ho Park, Hyun Kook, In-Kyu Lee, and Kyoungho Suk, “A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation,” Journal Of Neuroinflammation, vol. 13, 2016. View at Publisher · View at Google Scholar
  • Eunji Kim, Young-Jin Son, Yanyan Yang, Ting Shen, Ikyon Kim, Adithan Aravinthan, Jong-Hoon Kim, and Jae Cho, “1-(2,3-Dibenzimidazol-2-ylpropyl)-2-methoxybenzene Is a Syk Inhibitor with Anti-Inflammatory Properties,” Molecules, vol. 21, no. 4, pp. 508, 2016. View at Publisher · View at Google Scholar
  • Maria Pia dell'Oglio, Simona Simone, Marco Ciccone, Roberto Corciulo, Michele Gesualdo, Annapaola Zito, Francesca Cortese, Giuseppe Castellano, Margherita Gigante, Loreto Gesualdo, Giuseppe Grandaliano, and Giovanni Battista Pertosa, “Neutrophil-dependent pentraxin-3 and reactive oxygen species production modulate endothelial dysfunction in haemodialysis patients,” Nephrology Dialysis Transplantation, pp. gfw363, 2016. View at Publisher · View at Google Scholar
  • Nadine Schneble, Julia Müller, Stefanie Kliche, Reinhard Bauer, Reinhard Wetzker, Frank-D. Böhmer, Zhao-Qi Wang, and Jörg P. Müller, “The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase,” Glia, vol. 65, no. 2, pp. 416–428, 2016. View at Publisher · View at Google Scholar
  • In-Sook Han Lee, Jun Ho Kim, Young-Jin Son, Eun Jeong Jeong, Tae Woong Kim, Sungjae Yang, Jae Youl Cho, Yong Kim, Deok Jeong, Sunggyu Kim, and Byong Chul Yoo, “Pyrrole-derivative of chalcone, (E)-3-phenyl-1-(2-pyrrolyl)-2- propenone, inhibits inflammatory responses via inhibition of src, syk, and TAK1 kinase activities,” Biomolecules and Therapeutics, vol. 24, no. 6, pp. 595–603, 2016. View at Publisher · View at Google Scholar
  • Xiaohong Zhou, Mirja Ramke, Ashish V Chintakuntlawar, Jeong Yoon Lee, Jaya Rajaiya, and James Chodosh, “Role of MyD88 in adenovirus keratitis,” Immunology and Cell Biology, vol. 95, no. 1, pp. 108–116, 2016. View at Publisher · View at Google Scholar
  • Jae Gwang Park, Seung Cheol Kim, Yun Hwan Kim, Woo Seok Yang, Yong Kim, Sungyoul Hong, Kyung-Hee Kim, Byong Chul Yoo, Shi Hyung Kim, Jong-Hoon Kim, and Jae Youl Cho, “Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid,” Mediators of Inflammation, vol. 2016, pp. 1–12, 2016. View at Publisher · View at Google Scholar
  • Dubravko Jelić, Agnieszka D. Lower-Nedza, Adelheid H. Brantner, Biljana Blažeković, Baolin Bian, Jian Yang, Karmen Brajša, and Sanda Vladimir-Knežević, “Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6,” Journal of Chemistry, vol. 2016, pp. 1–6, 2016. View at Publisher · View at Google Scholar
  • Young-Su Yi, “Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases,” Mediators of Inflammation, vol. 2016, pp. 1–12, 2016. View at Publisher · View at Google Scholar
  • Liliana M. R. Silva, Tamara Muñoz-Caro, Rafael A. Burgos, Maria A. Hidalgo, Anja Taubert, and Carlos Hermosilla, “ Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo ,” Mediators of Inflammation, vol. 2016, pp. 1–13, 2016. View at Publisher · View at Google Scholar
  • Yong Kim, Eun Jeong Jeong, In-Sook Han Lee, Mi-Yeon Kim, and Jae Youl Cho, “ ( E )-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of inflammatory responses via inhibition of Src, Syk, and NF-κB ,” The Korean Journal of Physiology & Pharmacology, vol. 20, no. 1, pp. 91, 2016. View at Publisher · View at Google Scholar
  • Jia Shao, Inge Stout, Peter J. M. Hendriksen, Henk van Loveren, Ad A. C. M. Peijnenburg, and Oscar L. Volger, “Protein phosphorylation profiling identifies potential mechanisms for direct immunotoxicity,” Journal Of Immunotoxicology, vol. 13, no. 1, pp. 97–107, 2016. View at Publisher · View at Google Scholar
  • Cui-cui Yang, Xue-xian Kuai, Wen-bin Gao, Jian-chun Yu, Qi Wang, Lin Li, and Lan Zhang, “Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration,” Journal Of Alzheimers Disease, vol. 51, no. 1, pp. 33–44, 2016. View at Publisher · View at Google Scholar
  • Gyubyung Park, Eunji Kim, Young-Jin Son, Deok Hyo Yoon, Gi-Ho Sung, Adithan Aravinthan, Yung Chul Park, Jong-Hoon Kim, and Jae Youl Cho, “Anti-inflammatory effect of torilidis fructus ethanol extract through inhibition of Src,” Pharmaceutical Biology, vol. 55, no. 1, pp. 2074–2082, 2017. View at Publisher · View at Google Scholar
  • Young-Su Yi, “Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses,” Immunology, 2017. View at Publisher · View at Google Scholar
  • Xin Wang, Zi-Feng Zhang, Gui-Hong Zheng, Ai-Min Wang, Chun-Hui Sun, Su-Ping Qin, Juan Zhuang, Jun Lu, Dai-Fu Ma, and Yuan-Lin Zheng, “Attenuation of hepatic steatosis by purple sweet potato colour is associated with blocking Src/ERK/C/EBPβ signalling in high-fat-diet–treated mice,” Applied Physiology, Nutrition, and Metabolism, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • Weiqun Lin, Wenting Wang, Dongliang Wang, and Wenhua Ling, “Quercetin protects against atherosclerosis by inhibiting dendritic cell activation,” Molecular Nutrition & Food Research, pp. 1700031, 2017. View at Publisher · View at Google Scholar
  • Rui Qing, Zezhi Huang, Yufei Tang, Qingke Xiang, and Fan Yang, “Cordycepin negatively modulates lipopolysaccharide-induced cytokine production by up-regulation of heme oxygenase-1,” International Immunopharmacology, vol. 47, pp. 20–27, 2017. View at Publisher · View at Google Scholar
  • Sang Yun Han, Juewon Kim, Eunji Kim, Su Hwan Kim, Dae Bang Seo, Jong-Hoon Kim, Song Seok Shin, and Jae Youl Cho, “AKT-targeted anti-inflammatory activity of Panax ginseng calyx ethanolic extract,” Journal of Ginseng Research, 2017. View at Publisher · View at Google Scholar
  • Prachi Tewari, Payal Mandal, Ruchi Roy, Somya Asthana, Premendra D Dwivedi, Mukul Das, and Anurag Tripathi, “A novel function of TLR4 in mediating the immunomodulatory effect of Benzanthrone, an environmental pollutant,” Toxicology Letters, 2017. View at Publisher · View at Google Scholar
  • Jeong-Ook Lee, Woo Seok Yang, Jae Gwang Park, Deok Jeong, Han Gyung Kim, Kee Dong Yoon, Adithan Aravinthan, Jong-Hoon Kim, Eunji Kim, and Jae Youl Cho, “Src and Syk contribute to the anti-inflammatory activities of Achyranthes aspera ethanolic extract,” Journal of Ethnopharmacology, 2017. View at Publisher · View at Google Scholar
  • Hong Lu, “Crosstalk of 5′-Monophosphate-Activated Protein Kinase (AMPK) with Extracellular and Intracellular Signaling Pathways in the Regulation of Nutrient Metabolism and Cell Survival in the Liver,” Current Pharmacology Reports, 2017. View at Publisher · View at Google Scholar
  • Young-Su Yi, Mi-Yeon Kim, and Jae Youl Cho, “JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38,” Korean Journal of Physiology and Pharmacology, vol. 21, no. 3, pp. 345–352, 2017. View at Publisher · View at Google Scholar
  • Woo Seok Yang, Donghyun Kim, Young-Su Yi, Ji Hye Kim, Hye Yoon Jeong, Kyeonghwan Hwang, Jong-Hoon Kim, Junseong Park, and Jae Youl Cho, “AKT-targeted anti-inflammatory activity of the methanol extract of Chrysanthemum indicum var. albescens,” Journal of Ethnopharmacology, vol. 201, pp. 82–90, 2017. View at Publisher · View at Google Scholar
  • Jae Sik Yu, Jun Ho Kim, Seulah Lee, Kiwon Jung, Ki Hyun Kim, and Jae Youl Cho, “ Src/Syk-Targeted Anti-Inflammatory Actions of Triterpenoidal Saponins from Gac ( Momordica cochinchinensis ) Seeds ,” The American Journal of Chinese Medicine, pp. 1–15, 2017. View at Publisher · View at Google Scholar
  • Xiaoting Hua, Liang Song, Qingyou Xia, Fei Wang, and Xianyang Li, “Identification of tyrosine kinase Src responsible for antimicrobial peptides production in Bombyx mori,” Protein and Peptide Letters, vol. 24, no. 2, pp. 174–180, 2017. View at Publisher · View at Google Scholar
  • Ester Gangoso, Rocío Talaverón, Myriam Jaraíz-Rodríguez, Marta Domínguez-Prieto, Pascal Ezan, Annette Koulakoff, José M. Medina, Christian Giaume, and Arantxa Tabernero, “A c-Src Inhibitor Peptide Based on Connexin43 Exerts Neuroprotective Effects through the Inhibition of Glial Hemichannel Activity,” Frontiers in Molecular Neuroscience, vol. 10, 2017. View at Publisher · View at Google Scholar
  • Young-Su Yi, “Roles of ginsenosides in inflammasome activation,” Journal of Ginseng Research, 2017. View at Publisher · View at Google Scholar
  • Md Rashedunnabi Akanda, and Byung-Yong Park, “Involvement of MAPK/NF-κB signal transduction pathways: Camellia japonica mitigates inflammation and gastric ulcer,” Biomedicine & Pharmacotherapy, vol. 95, pp. 1139–1146, 2017. View at Publisher · View at Google Scholar
  • Zhengang Tao, Xia Meng, Yan-qi Han, Ming-ming Xue, Shifei Wu, Ping Wu, Ying Yuan, Qiang Zhu, Tie-Jun Zhang, and Catherine C. L. Wong, “Therapeutic Mechanistic Studies of ShuFengJieDu Capsule in an Acute Lung Injury Animal Model Using Quantitative Proteomics Technology,” Journal of Proteome Research, 2017. View at Publisher · View at Google Scholar
  • Chongxiang Xiong, Ting C. Zhao, Shougang Zhuang, Xiujuan Zang, Xiaoxu Zhou, Lirong Liu, Monica V. Masucci, Jinhua Tang, Xuezhu Li, Na Liu, and George Bayliss, “Pharmacological inhibition of Src kinase protects against acute kidney injury in a murine model of renal ischemia/reperfusion,” Oncotarget, vol. 8, no. 19, pp. 31238–31253, 2017. View at Publisher · View at Google Scholar
  • Fei Wang, Wei Zhang, Chao Wang, Xu Fang, Hao Cheng, Sheng Liu, and Xu-Lin Chen, “Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-κB pathway,” Oncotarget, vol. 8, no. 21, pp. 34099–34110, 2017. View at Publisher · View at Google Scholar
  • Jae Gwang Park, Young-Su Yi, Yo Han Hong, Sulgi Yoo, Sang Yun Han, Eunji Kim, Seong-Gu Jeong, Adithan Aravinthan, Kwang Soo Baik, Su Young Choi, Young-Jin Son, Jong-Hoon Kim, and Jae Youl Cho, “ Tabetri™ ( Tabebuia avellanedae Ethanol Extract) Ameliorates Osteoarthritis Symptoms Induced by Monoiodoacetate through Its Anti-Inflammatory and Chondroprotective Activities ,” Mediators of Inflammation, vol. 2017, pp. 1–14, 2017. View at Publisher · View at Google Scholar
  • Yong Kim, Han Gyung Kim, Sang Yun Han, Deok Jeong, Woo Seok Yang, Jung-Il Kim, Ji Hye Kim, Young-Su Yi, and Jae Youl Cho, “Hydroquinone suppresses IFN-β expression by targeting AKT/IRF3 pathway,” The Korean Journal of Physiology & Pharmacology, vol. 21, no. 5, pp. 547, 2017. View at Publisher · View at Google Scholar
  • Han Gyung Kim, Mi Yeon Kim, and Jae Youl Cho, “Alisma canaliculatum ethanol extract suppresses inflammatory responses in LPS-stimulated macrophages, HCl/EtOH-induced gastritis, and DSS-triggered colitis by targeting Src/Syk and TAK1 activities,” Journal of Ethnopharmacology, 2018. View at Publisher · View at Google Scholar
  • Deok Jeong, Jongsung Lee, Seong-Gu Jeong, Yo Han Hong, Sulgi Yoo, Sang Yun Han, Ji Hye Kim, Sunggyu Kim, Jin Sic Kim, Young Soo Chung, Jong-Hoon Kim, Young-Su Yi, and Jae Youl Cho, “Artemisia asiatica ethanol extract exhibits anti-photoaging activity,” Journal of Ethnopharmacology, 2018. View at Publisher · View at Google Scholar
  • Eunji Kim, Young-Su Yi, Young-Jin Son, Sang Yun Han, Dong Hyun Kim, Gibaeg Nam, Mohammad Amjad Hossain, Jong-Hoon Kim, Junseong Park, and Jae Youl Cho, “BIOGF1K, a compound K-rich fraction of ginseng, plays an antiinflammatory role by targeting an activator protein-1 signaling pathway in RAW264.7 macrophage-like cells,” Journal of Ginseng Research, 2018. View at Publisher · View at Google Scholar
  • Md. Areeful Haque, Ibrahim Jantan, and Hemavathy Harikrishnan, “Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-κB/MAPK/PI3K-Akt signaling pathways,” International Immunopharmacology, vol. 55, pp. 312–322, 2018. View at Publisher · View at Google Scholar
  • Han Gyung Kim, Subin Choi, Jongsung Lee, Yo Han Hong, Deok Jeong, Keejung Yoon, Deok Hyo Yoon, Gi-Ho Sung, Seungihm Lee, Suntaek Hong, Young-Su Yi, Jong-Hoon Kim, and Jae Youl Cho, “ Src Is a Prime Target Inhibited by Celtis choseniana Methanol Extract in Its Anti-Inflammatory Action ,” Evidence-Based Complementary and Alternative Medicine, vol. 2018, pp. 1–17, 2018. View at Publisher · View at Google Scholar
  • Jae Gwang Park, Young-Su Yi, Sang Yun Han, Yo Han Hong, Sulgi Yoo, Eunji Kim, Seong-Gu Jeong, Adithan Aravinthan, Kwang Soo Baik, Su Young Choi, Jung-Il Kim, Young-Jin Son, Jong-Hoon Kim, and Jae Youl Cho, “ Tabetri™ ( Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice ,” Mediators of Inflammation, vol. 2018, pp. 1–11, 2018. View at Publisher · View at Google Scholar