The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses

Table 1

Src family kinases and their functions in immune responses.

Molecule	Distribution	Specific functions in immune responses	Reference
Src	Ubiquitous	- See Sections 2, 3, and 4
Fyn	Ubiquitous	- CD5 glycoprotein-mediated T-cell inhibition by inhibitory phosphorylation of Fyn	[76]
		- Rac and stress kinase activation in TCR signaling by Fyn
Yes	Ubiquitous	- LTB4-mediated degranulation of human neutrophils by Yes activation	[77]
Frk	Ubiquitous	- Unclear
Blk	G, Mo, Ma, B	- Preferentially expression in B-cell lineage. Control of proliferation during B-cell development	[78]
Fgr	G, Mo, Ma	- Inhibition of Hck and Fgr kinase activity	[79]
		- Inhibition of beta 2 integrin receptor and Syk kinase signaling by Fgr	[80]
Hck	G, Mo, Ma	- Inhibition of Hck and Fgr kinase activity	[79]
Lck	T, B	- Modulation of signaling and cellular fate of B-1 cells	[81]
		- Promoting B-cell development	[82]
Lyn	P, G, Mo, Ma, B	- Redox sensor mediating initial neutrophil recruitment to wounds	[83]
		- Inhibition of platelet aggregation with PECAM-1	[84]

^*Data from http://www.proteinkinase.de. G: granulocyte, Mo: monocyte, Ma: macrophage, B: B cell, T: T cell, and P: platelet.