|
| Receptor | Ligand | Adapter molecules | Location | Cell type |
|
| TLR1 + TLR2 | Bacterial lipoproteins | MyD88/Mal | Plasma membrane | Monocytes/macrophages
A subset of dendritic cells
B lymphocytes |
| TLR2 + ? | GPI anchors (parasites),
bacterial porins, and HMGB1 | MyD88/Mal | Plasma membrane | Monocytes/macrophages
A subset of dendritic cells
B lymphocytes |
| TLR3 | dsRNA, poly I:C | TRIF | Intracellular membrane | Dendritic cells
B lymphocytes |
| TLR4 | LPS, HSPs, HMGB1, some viral proteins | MyD88/Mal/TRAM/TRIF | Plasma membrane | Monocytes/macrophages
Myeloid dendritic cells
Mast cells
B lymphocytes
Intestinal epithelium |
| TLR5 | Bacterial flagellin | MyD88 | Plasma membrane | Monocyte/macrophages
A subset of dendritic cells
Intestinal epithelium |
| TLR2 + TLR6 | Bacterial lipoproteins from mycoplasma,
lipoteichoic acid, and
yeast cell wall mannans | MyD88/Mal | Plasma membrane | Monocytes/macrophages
Mast cells
B lymphocytes |
| TLR7 | Imidazoquinoline
ssRNA (viral) | MyD88 | Intracellular membrane | Monocytes/macrophages
Plasmacytoid dendritic cells
B lymphocytes |
| TLR8 | Imidazoquinoline
ssRNA (viral) | MyD88 | Intracellular membrane | Monocytes/macrophages
A subset of dendritic cells
Mast cells |
| TLR9 | CpG-containing DNA
(viral and bacterial) | MyD88 | Intracellular membrane | Monocytes/macrophages
A subset of dendritic cells
Mast cells
B cell |
| TLR10 | Unknown | MyD88 | Plasma membrane | B lymphocytes
Dendritic cells
Eosinophils |
TLR11
(only mouse and rat) | Toxoplasma profilin | MyD88 | Plasma membrane | Monocytes/macrophages
A subset of dendritic cells
Mast cells |
TLR12
(only mouse and rat) | Unknown | MyD88 | Plasma membrane | Neurons |
TLR13
(only mouse and rat) | Unknown | MyD88, TAK-1 | Plasma membrane | |
|
