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Mediators of Inflammation
Volume 2012, Article ID 546786, 16 pages
http://dx.doi.org/10.1155/2012/546786
Review Article

Mechanism of Inflammation in Age-Related Macular Degeneration

1Department of Ophthalmology, University of Ferrara, Ferrara, Italy
2Department of Health Sciences, University of Molise, Campobasso, Italy
3Department of Ophthalmology, Istituto Clinico Humanitas, Milan, Italy
4Department of Ophthalmology, University of Brescia, Brescia, Italy
5Center for Retinitis Pigmentosa of Veneto Region, ULSS 15 Alta Padovana, Camposampiero, Italy

Received 4 July 2012; Accepted 2 October 2012

Academic Editor: Ahmed M. Abu El-Asrar

Copyright © 2012 Francesco Parmeggiani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [61 citations]

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  • Carla Enrica Gallenga, Francesco Parmeggiani, Ciro Costagliola, Adolfo Sebastiani, and Pier Enrico Gallenga, “Inflammaging: should this term be suitable for age related macular degeneration too?,” Inflammation Research, 2013. View at Publisher · View at Google Scholar
  • Francesco Parmeggiani, Francesco S. Sorrentino, Mario R. Romano, Ciro Costagliola, Francesco Semeraro, Carlo Incorvaia, Sergio D'Angelo, Paolo Perri, Katia De Nadai, Elia Bonomo Roversi, Paola Franceschelli, Adolfo Sebastiani, and Michele Rubini, “Mechanism of Inflammation in Age-Related Macular Degeneration: An Up-to-Date on Genetic Landmarks,” Mediators of Inflammation, 2013. View at Publisher · View at Google Scholar
  • Andrea Russo, Ciro Costagliola, Luisa Delcassi, Francesco Parmeggiani, Mario R. Romano, Roberto dell'Omo, and Francesco Semeraro, “Topical Nonsteroidal Anti-Inflammatory Drugs for Macular Edema,” Mediators of Inflammation, vol. 2013, pp. 1–11, 2013. View at Publisher · View at Google Scholar
  • Ya Fatou Njie-Mbye, Madhura Kulkarni-Chitnis, Catherine A. Opere, Aaron Barrett, and Sunny E. Ohia, “Lipid peroxidation: Pathophysiological and pharmacological implications in the eye,” Frontiers in Physiology, vol. 4, 2013. View at Publisher · View at Google Scholar
  • Elizabeth J Johnson, “Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan,” Nutrition Reviews, 2014. View at Publisher · View at Google Scholar
  • Yuan Tian, Aize Kijlstra, Rob L. P. van der Veen, Maria Makridaki, Ian J. Murray, and Tos T. J. M. Berendschot, “Lutein supplementation leads to decreased soluble complement membrane attack complex sC5b-9 plasma levels,” Acta Ophthalmologica, 2014. View at Publisher · View at Google Scholar
  • Volkan Okur, Ozan Cetin, Ebru Cetin, Emre Tepeli, Yunus Bulgu, and Cem Yildirim, “ HIF1A as a major vascular endothelial growth factor regulator: do its polymorphisms have an association with age-related macular degeneration? ,” Clinical & Experimental Ophthalmology, 2014. View at Publisher · View at Google Scholar
  • Nilufer Ilhan, Mutlu Cihan Daglioglu, Ozgur Ilhan, Mesut Coskun, Esra Ayhan Tuzcu, Hilal Kahraman, and Ugurcan Keskin, “Assessment of Neutrophil/Lymphocyte Ratio in Patients with Age-related Macular Degeneration,” Ocular Immunology and Inflammation, pp. 1–4, 2014. View at Publisher · View at Google Scholar
  • Anne Louise Askou, “Development of gene therapy for treatment of age-related macular degeneration,” Acta Ophthalmologica, vol. 92, pp. 1–38, 2014. View at Publisher · View at Google Scholar
  • Francesco Semeraro, Francesco Morescalchi, Sarah Duse, Elena Gambicorti, Mario R Romano, and Ciro Costagliola, “Systemic thromboembolic adverse events in patients treated with intravitreal anti-VEGF drugs for neovascular age-related macular degeneration: an overview,” Expert Opinion on Drug Safety, pp. 1–18, 2014. View at Publisher · View at Google Scholar
  • Robert B. Nussenblatt, Richard W.J. Lee, Emily Chew, Lai Wei, Baoying Liu, Nida Sen, Andrew D. Dick, and Frederick L. Ferris, “Immune Responses in Age Related Macular Degeneration and a possible Long Term Therapeutic Strategy for Prevention,” American Journal of Ophthalmology, 2014. View at Publisher · View at Google Scholar
  • Raj Chovatiya, and Ruslan Medzhitov, “Stress, Inflammation, and Defense of Homeostasis,” Molecular Cell, vol. 54, no. 2, pp. 281–288, 2014. View at Publisher · View at Google Scholar
  • Michael B. Powner, Jenny A. G. McKenzie, Gregory J. Christianson, and Derry C. Roopenian, “Expression of Neonatal Fc Receptor in the Eye,” Investigative Ophthalmology & Visual Science, vol. 55, no. 3, pp. 1607–1615, 2014. View at Publisher · View at Google Scholar
  • Fernando Cruz-Guilloty, Ali M. Saeed, Stephanie Duffort, Marisol Cano, Katayoon B. Ebrahimi, Asha Ballmick, Yaohong Tan, Hua Wang, James M. Laird, Robert G. Salomon, James T. Handa, and Victor L. Perez, “T Cells and Macrophages Responding to Oxidative Damage Cooperate in Pathogenesis of a Mouse Model of Age-Related Macular Degeneration,” Plos One, vol. 9, no. 2, 2014. View at Publisher · View at Google Scholar
  • Michaela Dithmer, Sabine Fuchs, Yang Shi, Harald Schmidt, Elisabeth Richert, Johann Roider, and Alexa Klettner, “Fucoidan Reduces Secretion and Expression of Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium and Reduces Angiogenesis In Vitro,” Plos One, vol. 9, no. 2, 2014. View at Publisher · View at Google Scholar
  • Lama Mulki, J. Harry Sweigard, and Kip M. Connor, “Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay,” Jove-Journal Of Visualized Experiments, no. 94, 2014. View at Publisher · View at Google Scholar
  • Sarah X. Zhang, Jacey H. Ma, Maulasri Bhatta, Steven J. Fliesler, and Joshua J. Wang, “The Unfolded Protein Response in Retinal Vascular Diseases: Implications and Therapeutic Potential Beyond Protein Folding,” Progress in Retinal and Eye Research, 2014. View at Publisher · View at Google Scholar
  • Yunus Bulgu, Gokhan Ozan Cetin, Vildan Caner, Ebru Nevin Cetin, Volkan Yaylali, and Cem Yildirim, “Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population,” International Journal of Ophthalmology, vol. 7, no. 5, pp. 773–777, 2014. View at Publisher · View at Google Scholar
  • Giuseppe Tridentepp. 1–210, 2014. View at Publisher · View at Google Scholar
  • Małgorzata Nita, Andrzej Grzybowski, Francisco J. Ascaso, and Valentín Huerva, “Age-Related Macular Degeneration in the Aspect of Chronic Low-Grade Inflammation (Pathophysiological ParaInflammation),” Mediators of Inflammation, vol. 2014, pp. 1–10, 2014. View at Publisher · View at Google Scholar
  • Yunus Bulgu, Gokhan Ozan Cetin, Vildan Caner, Ebru Nevin Cetin, Volkan Yaylali, and Cem Yildirim, “Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population.,” International journal of ophthalmology, vol. 7, no. 5, pp. 773–7, 2014. View at Publisher · View at Google Scholar
  • F. Favero, S. Glimne, K. Tear Fahnehjelm, and J. Eklund, “Vision, light and aging: A literature overview on older-age workers,” Work-A Journal of Prevention Assessment & Rehabilitation, vol. 47, no. 3, pp. 399–412, 2014. View at Publisher · View at Google Scholar
  • Deborah A. Ferrington, Debasish Sinha, and Kai Kaarniranta, “Defects in Retinal Pigment Epithelial Cell Proteolysis and the Pathology Associated with Age-related Macular Degeneration,” Progress in Retinal and Eye Research, 2015. View at Publisher · View at Google Scholar
  • Francesco Semeraro, Andrea Russo, Luisa Delcassi, Mario R. Romano, Michele Rinaldi, Flavia Chiosi, and Ciro Costagliola, “Treatment Of Exudative Age-Related Macular Degeneration With Ranibizumab Combined With Ketorolac Eyedrops Or Photodynamic Therapy,” Retina, vol. 35, no. 8, pp. 1547–1554, 2015. View at Publisher · View at Google Scholar
  • Francesco Parmeggiani, Katia De Nadai, Roberto Dell’Omo, Andrea Russo, Donato Gemmati, Paolo Perri, Ciro Costagliola, Francesco Semeraro, Mario R. Romano, Michele Rinaldi, Carla Enrica Gallenga, Maria Luisa Serino, Carlo Incorvaia, and Sergio D’Angelo, “Effect of factor XIII-a G185T polymorphism on visual prognosis after photodynamic therapy for neovascular macular degeneration,” International Journal of Molecular Sciences, vol. 16, no. 8, pp. 19796–19811, 2015. View at Publisher · View at Google Scholar
  • Francesco Semeraro, Andrea Russo, Elena Gambicorti, Sarah Duse, Francesco Morescalchi, Sara Vezzoli, and Ciro Costagliola, “Efficacy and vitreous levels of topical NSAIDs,” Expert Opinion on Drug Delivery, pp. 1–16, 2015. View at Publisher · View at Google Scholar
  • Edward Chaum, Christina S. Winborn, and Sujoy Bhattacharya, “Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium,” Mammalian Genome, 2015. View at Publisher · View at Google Scholar
  • Miriam Kolko, Fia Vosborg, Ulrik L. Henriksen, Md Mahdi Hasan-Olive, Elisabeth Holm Diget, Rupali Vohra, Iswariya Raja Sridevi Gurubaran, Albert Gjedde, Shelton Tendai Mariga, Dorte M. Skytt, Tor Paaske Utheim, Jon Storm-Mathisen, and Linda H. Bergersen, “Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease,” Neurochemical Research, 2015. View at Publisher · View at Google Scholar
  • Judith Lechner, Mei Chen, Ruth E. Hogg, Levente Toth, Giuliana Silvestri, Usha Chakravarthy, and Heping Xu, “Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration,” Scientific Reports, vol. 5, pp. 16754, 2015. View at Publisher · View at Google Scholar
  • Marieh Esmaeelpour, and Wolfgang Drexlerpp. 1833–1847, 2015. View at Publisher · View at Google Scholar
  • Chaoqi Liu, Lining Cao, Shuai Yang, Linxinyu Xu, Pei Liu, Fang Wang, and Ding Xu, “Subretinal injection of amyloid-beta peptide accelerates RPE cell senescence and retinal degeneration,” International Journal Of Molecular Medicine, vol. 35, no. 1, pp. 169–176, 2015. View at Publisher · View at Google Scholar
  • Yalong Dang, Chun Zhang, and Yu Zhu, “Stem cell therapies for age-related macular degeneration: the past, present, and future,” Clinical Interventions In Aging, vol. 10, pp. 255–264, 2015. View at Publisher · View at Google Scholar
  • Burcin Kepez Yildiz, Mehmet Ali Ergun, Sezen Ergun, Fulya Yaylacioglu Tuncay, Sengul Ozdek, and Sehri Elbeg, “CFH Y402H and VEGF Polymorphisms and Anti-VEGF Treatment Response in Exudative Age-Related Macular Degeneration,” Ophthalmic Research, vol. 56, no. 3, pp. 132–138, 2016. View at Publisher · View at Google Scholar
  • Gopalan Gnanaguru, Ariel R. Choi, Dhanesh Amarnani, and Patricia A. D’Amore, “Oxidized lipoprotein uptake through the CD36 receptor activates the NLRP3 inflammasome in human retinal pigment epithelial cells,” Investigative Ophthalmology and Visual Science, vol. 57, no. 11, pp. 4704–4712, 2016. View at Publisher · View at Google Scholar
  • Miriam Kolko, Fia Vosborg, Ulrik L. Henriksen, Md Mahdi Hasan-Olive, Elisabeth Holm Diget, Rupali Vohra, Iswariya Raja Sridevi Gurubaran, Albert Gjedde, Shelton Tendai Mariga, Dorte M. Skytt, Tor Paaske Utheim, Jon Storm-Mathisen, and Linda H. Bergersen, “Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease (vol 41, pg 1237, 2016),” Neurochemical Research, vol. 41, no. 6, pp. 1237–1237, 2016. View at Publisher · View at Google Scholar
  • Moshe Ehrenberg, Scott Ehrenberg, Ouri Schwob, and Ofra Benny, “Murine fundus fluorescein angiography: An alternative approach using a handheld camera,” Experimental Eye Research, 2016. View at Publisher · View at Google Scholar
  • Z. A.D Pockpa, X. Struillou, N.T Coulibaly, M. Weber, A. Soueidan, and Z. Badran, “Potential relationship between periodontal diseases and eye diseases,” Medical Hypotheses, 2016. View at Publisher · View at Google Scholar
  • Anzhela Zh. Fursova, Natalia G. Kolosova, Elena E. Korbolina, Anna A. Zhdankina, and Oyuna S. Kozhevnikova, “Genes of susceptibility to early neurodegenerative changes in the rat retina and brain: Analysis by means of congenic strains,” BMC Genetics, vol. 17, 2016. View at Publisher · View at Google Scholar
  • Katie L. Pennington, and Margaret M. DeAngelis, “Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors,” Eye and Vision, vol. 3, no. 1, 2016. View at Publisher · View at Google Scholar
  • Arun Bhaskaran, Harry A. Scott, Umar Mohideen, Kaustabh Ghosh, Andrea P. Cabrera, Jun Xu, and Xiao Yang, “Senescence increases choroidal endothelial stiffness and susceptibility to complement injury: Implications for choriocapillaris loss in AMD,” Investigative Ophthalmology and Visual Science, vol. 57, no. 14, pp. 5910–5918, 2016. View at Publisher · View at Google Scholar
  • Amitabh Sharma, Susan Dina Ghiassian, Joseph Loscalzo, Maksim Kitsak, Jörg Menche, Emre Guney, and Albert-László Barabási, “Tissue Specificity of Human Disease Module,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Scott J. Robbie, Anastasios Georgiadis, Susie E. Barker, Yanai Duran, Alexander J. Smith, Robin R. Ali, Ulrich F.O. Luhmann, and James W. Bainbridge, “Enhanced Ccl2-Ccr2 signalling drives more severe choroidal neovascularisation with aging,” Neurobiology of Aging, 2016. View at Publisher · View at Google Scholar
  • Gyu Hyun Kim, Hyung Il Kim, Sun-Sook Paik, Sung Won Jung, Seungbum Kang, and In-Beom Kim, “Functional and morphological evaluation of blue light-emitting diode-induced retinal degeneration in mice,” Graefe's Archive for Clinical and Experimental Ophthalmology, 2016. View at Publisher · View at Google Scholar
  • Shira Hagbi-Levi, Michelle Grunin, Sarah Elbaz-Hayoun, David Tal, Alexey Obolensky, Joel Hanhart, Eyal Banin, Tal Burstyn-Cohen, and Itay Chowers, “Retinal Phenotype following Combined Deletion of the Chemokine Receptor CCR2 and the Chemokine CX3CL1 in Mice,” Ophthalmic Research, vol. 55, no. 3, pp. 126–134, 2016. View at Publisher · View at Google Scholar
  • Huiling Li, Sumana R. Chintalapudi, and Monica M. Jablonski, “Current drug and molecular therapies for the treatment of atrophic age-related macular degeneration: phase I to phase III clinical development,” Expert Opinion on Investigational Drugs, pp. 1–12, 2017. View at Publisher · View at Google Scholar
  • Wenxin Ma, Yikui Zhang, Chun Gao, Robert N. Fariss, Johnny Tam, and Wai T. Wong, “Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Almudena Crooke, Fernando Huete-Toral, Basilio Colligris, and Jesús Pintor, “The role and therapeutic potential of melatonin in age-related ocular diseases,” Journal of Pineal Research, pp. e12430, 2017. View at Publisher · View at Google Scholar
  • Ke Wang, Xue Zhu, Kai Zhang, Yong Yao, Miao Zhuang, Chengye Tan, Fanfan Zhou, and Ling Zhu, “Puerarin inhibits amyloid β-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses,” Experimental Cell Research, 2017. View at Publisher · View at Google Scholar
  • Mark A. Fields, Hannah E. Bowrey, Jie Gong, Ernesto F. Moreira, Hui Cai, and Lucian V. Del Priore, “Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells,” Plos One, vol. 12, no. 5, pp. e0177763, 2017. View at Publisher · View at Google Scholar
  • Zhongjie Fu, Yan Gong, Raffael Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Steven S. Meng, Samuel B. Burnim, Nicholas J. Saba, Thomas W. Fredrick, Peyton C. Morss, Ann Hellstrom, Saswata Talukdar, and Lois E.H. Smith, “FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice,” Cell Reports, vol. 18, no. 7, pp. 1606–1613, 2017. View at Publisher · View at Google Scholar
  • Alfredo Layana, Angelo Minnella, Gerhard Garhöfer, Tariq Aslam, Frank Holz, Anita Leys, Rufino Silva, Cécile Delcourt, Eric Souied, and Johanna Seddon, “Vitamin D and Age-Related Macular Degeneration,” Nutrients, vol. 9, no. 10, pp. 1120, 2017. View at Publisher · View at Google Scholar
  • Konenkov, Eremina, Trunov, Shevchenko, Prokofyev, Chernykh, Dudnikova, and Kashkina, “Network approach to analysis of quantitative trait loci for tumor necrosis factor (TNFα-863, TNFα-308, TNFα-238), vascular endothelial growth factor (VEGF-2578, VEGF+936) and matrix metalloproteinase (MMP2-1306, MMP3-1171, MMP9-1569) genes in agerelated macular degeneration,” Medical Immunology (Russia), vol. 19, no. 5, pp. 537–546, 2017. View at Publisher · View at Google Scholar
  • Chatarina Löfqvist, Ann Hellström, Raffael Liegl, Ye Sun, Steven S. Meng, Zhongjie Fu, John Paul Sangiovanni, Lois E. H. Smith, Zhongxiao Wang, Yan Gong, Chi-Hsiu Liu, Bertan Cakir, and Samuel B. Burnim, “Adiponectin mediates dietary omega-3 long-chain polyunsaturated fatty acid protection against choroidal neovascularization in mice,” Investigative Ophthalmology and Visual Science, vol. 58, no. 10, pp. 3862–3870, 2017. View at Publisher · View at Google Scholar
  • Feiteng Lu, Shuang Liu, Qingyun Hao, Lixia Liu, Jing Zhang, Xiaolong Chen, Wang Hu, and Peng Huang, “ Association Between Complement Factor C2/C3/CFB/CFH Polymorphisms and Age-Related Macular Degeneration: A Meta-Analysis ,” Genetic Testing and Molecular Biomarkers, 2018. View at Publisher · View at Google Scholar
  • Nobuhiro Terao, Hideki Koizumi, Kentaro Kojima, Tetsuya Yamagishi, Yuji Yamamoto, Kengo Yoshii, Koji Kitazawa, Asako Hiraga, Munetoyo Toda, Shigeru Kinoshita, Chie Sotozono, and Junji Hamuro, “Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Audrey Voisin, Christelle Monville, Alexandra Plancheron, Anaïs Balbous, Afsaneh Gaillard, and Nicolas Leveziel, “hRPE cells derived from induced pluripotent stem cells are more sensitive to oxidative stress than ARPE-19 cells,” Experimental Eye Research, 2018. View at Publisher · View at Google Scholar
  • Kai Kaarniranta, Ali Koskela, Szabolcs Felszeghy, Niko Kivinen, Antero Salminen, and Anu Kauppinen, “Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration,” Biochimie, 2018. View at Publisher · View at Google Scholar
  • Nur Afiqah Mohamad, Wan Aliaa Wan Sulaiman, Patimah Ismail, Nor Fariza Ngah, Siew Mooi Ching, Fan Kee Hoo, Vasudevan Ramachandran, Hazlita Mohd Isa, Yoke Mun Chan, and Norshakimah Md Bakri, “R102G polymorphism of the complement component 3 gene in Malaysian subjects with neovascular age-related macular degeneration,” Egyptian Journal of Medical Human Genetics, vol. 19, no. 2, pp. 77–81, 2018. View at Publisher · View at Google Scholar
  • Andrea Sodi, Ilaria Passerini, Daniela Bacherini, Luca Boni, Simona Palchetti, Vittoria Murro, Orsola Caporossi, Dario Pasquale Mucciolo, Fabrizio Franco, Lorenzo Vannozzi, Francesca Torricelli, Elisabetta Pelo, Stanislao Rizzo, and Gianni Virgili, “CFH Y402H polymorphism in Italian patients with age-related macular degeneration, retinitis pigmentosa, and Stargardt disease,” Ophthalmic Genetics, pp. 1–7, 2018. View at Publisher · View at Google Scholar
  • Kyoung Sang Cho, Myeongcheol Shin, Sunhong Kim, and Sung Bae Lee, “Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases,” Oxidative Medicine and Cellular Longevity, vol. 2018, pp. 1–13, 2018. View at Publisher · View at Google Scholar
  • Luis Fernando Hernández-Zimbrón, Ruben Zamora-Alvarado, Lenin Ochoa-De la Paz, Raul Velez-Montoya, Edgar Zenteno, Rosario Gulias-Cañizo, Hugo Quiroz-Mercado, and Roberto Gonzalez-Salinas, “Age-Related Macular Degeneration: New Paradigms for Treatment and Management of AMD,” Oxidative Medicine and Cellular Longevity, vol. 2018, pp. 1–14, 2018. View at Publisher · View at Google Scholar