Review Article
Mechanism of Inflammation in Age-Related Macular Degeneration
Table 1
Main AMD-susceptibility genetic loci.
| | Locus | Role in immunoinflammatory pathways | Possibility of AMD-risk elevation |
| | CFH | Yes (complement system) | High (in carriers of polymorphic allele) | | ARMS2 | Not clarified | High (in carriers of polymorphic allele) | | HTRA1 | Possible (complement system) | High (in carriers of polymorphic allele) | | CFB | Yes (complement system) | Intermediate (in carriers of wild allele) | | C2 | Yes (complement system) | Intermediate (in carriers of wild allele) | | C3 | Yes (complement system) | Intermediate (in carriers of polymorphic allele) | | CFI | Yes (complement system) | Low (in carriers of polymorphic allele) | | TIMP3 | Yes (immunity in extracellular matrix) | Low (in carriers of polymorphic allele) | | LIPC | Not clarified | Low (in carriers of polymorphic allele) | | ABCR | No | Low (in carriers of polymorphic allele) | | APOE | No | Low (in carriers of polymorphic allele) |
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Legend: CFH: complement factor H; ARMS2: age-related maculopathy susceptibility 2; HTRA1: high-temperature requirement factor A of serine peptidase 1; CFB: complement factor B; C2: complement component 2; C3: complement component 3; CFI: complement factor I; TIMP3: tissue inhibitor of metalloproteinases 3; LIPC: hepatic lipase gene; ABCR: ATP-binding cassette transporter; APOE: apolipoprotein E.
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