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Mediators of Inflammation
Volume 2012, Article ID 568783, 11 pages
Review Article

Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game

1Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, San Diego, CA 92037, USA
2Instituto Nacional de Investigación Agraria y Alimentaria (INIA), Centro de Investigación en Sanidad Animal (CISA), Ctra. de Algete a El Casar s/n, Valdeolmos, 28130 Madrid, Spain
3Unidad de Inflamación y Cáncer, Área de Biología Celular y Desarrollo, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, Km 2,200, Majadahonda, 28220 Madrid, Spain

Received 3 September 2012; Accepted 7 November 2012

Academic Editor: Sung-Jen Wei

Copyright © 2012 Paqui G. Través et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The interaction between tumor progression and innate immune system has been well established in the last years. Indeed, several lines of clinical evidence indicate that immune cells such as tumor-associated macrophages (TAMs) interact with tumor cells, favoring growth, angiogenesis, and metastasis of a variety of cancers. In most tumors, TAMs show properties of an alternative polarization phenotype (M2) characterized by the expression of a series of chemokines, cytokines, and proteases that promote immunosuppression, tumor proliferation, and spreading of the cancer cells. Tumor suppressor genes have been traditionally linked to the regulation of cancer progression; however, a growing body of evidence indicates that these genes also play essential roles in the regulation of innate immunity pathways through molecular mechanisms that are still poorly understood. In this paper, we provide an overview of the immunobiology of TAMs as well as what is known about tumor suppressors in the context of immune responses. Recent advances regarding the role of the tumor suppressor ARF as a regulator of inflammation and macrophage polarization are also reviewed.