Role of PGE₂ in Asthma and Nonasthmatic Eosinophilic Bronchitis

Figure 1

Hypothetical mechanisms through which PGE₂ reduces the AHR and in NAEB. (a) The PGE₂ decreases the smooth muscle proliferation producing a reduction of muscular hyperplasia, via EP2 and EP4 receptors; (b) The PGE₂ closes the K_Ca 3.1 channel, preventing the migration of mastocytes by means of EP2. Both mechanisms will decrease or inhibit airway hyperresponsiveness, a relevant hallmark of asthma.