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Mediators of Inflammation
Volume 2012 (2012), Article ID 692467, 8 pages
Research Article

The PBDE-209 Exposure during Pregnancy and Lactation Impairs Immune Function in Rats

1The Third Affiliated Hospital of Guangzhou Medical College, The Medical Center for Critical Pregnant Women in Guangzhou, Duobao Road, No. 63, Guangzhou 510150, China
2Department of Pathology, Detroit Medical Center, Harper Hospital, School of Medicine, Wayne State University, 3990 John R, Detroit, MI 48201, USA

Received 5 November 2011; Revised 17 January 2012; Accepted 19 January 2012

Academic Editor: Antonio Macciò

Copyright © 2012 Xianbao Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the present study, we assessed the treatment effects of PBDE-209 administration on the immune function in rats during pregnancy and lactation. We harvested the blood and organs for flow cytometry, viability assay, enzyme-linked immunosorbent assay, and histological evaluation. The results of this study were the PBDE-209 exposure during pregnancy and lactation impairs immune function in rats. The results may contribute to understanding the mechanism of PBDE-209 in immune function.