Cyclooxygenase Inhibition in Sepsis: Is There Life after Death?
Figure 1
Influence of COX inhibitors on animal models of sepsis. (a) Studies were reviewed for experiments in which mortality was assessed for animals treated with COX inhibitors either before or after the systemic administration of pathogen-associated molecular patterns (generally, lipopolysaccharide). One mouse study (that showed a benefit to survival) included COX-2 knockout animals and not a pharmacological inhibitor. (b) Studies were reviewed for experiments in which mortality was assessed for animals treated with COX inhibitors either before or after the induction of systemic infection (see text for details). One mouse study (that showed a reduction in survival) included COX-2 knockout animals and not a pharmacological inhibitor.
