Interleukin-1β Accelerates the Onset of Stroke in Stroke-Prone Spontaneously Hypertensive Rats
Table 2
Effect of continuous IL-1β administration to SHR.
Before
1 week
2 weeks
3 weeks
4 weeks
BW (g)
Control
268.7 ± 9.5
295.5 ± 10.4
316.0 ± 11.7
327.9 ± 10.4
335.4 ± 10.7
IL-1β
266.4 ± 8.8
290.3 ± 11.2
300.0 ± 10.1**
317.9 ± 11.2
326.8 ± 11.4
SBP (mmHg)
Control
173 ± 11
158 ± 12
181 ± 17
173 ± 14
181 ± 8
IL-1β
175 ± 10
161 ± 11
172 ± 16
171 ± 10
174 ± 14
IL-1β (pg/mL)
Control
24.6 ± 15.5
26.1 ± 5.9
33.5 ± 17.7
37.9 ± 12.6
21.9 ± 8.2
IL-1β
25.4 ± 19.2
65.4 ± 18.8***
66.5 ± 20.6***
61.2 ± 30.7*
24.3 ± 6.2
Intake (g/day)
Control
23.9 ± 1.1
20.8 ± 1.1
20.6 ± 0.7
18.7 ± 0.9
IL-1β
22.6 ± 1.1*
19.7 ± 1.0*
20.8 ± 0.9
19.0 ± 0.9
Data presented as mean ± SD. Body weight (BW), systolic blood pressure (SBP), and plasma level of IL-1β were measured at before (10 weeks of age) and every one week of IL-1β administration. Food intake (Intake) is presented as the mean weight of food eaten per day during each week. *, **, *** versus Control by unpaired Student -test. in each group.