Research Article
Serum IL-18 Is Closely Associated with Renal Tubulointerstitial Injury and Predicts Renal Prognosis in IgA Nephropathy
Table 5
Comparison of clinical and histological parameters between IgAN patients with renal function deterioration or not in follow-up.
| | Parameters | Renal function deteriorated
(n = 26) | Renal function stable
(n = 50) | value |
| | Age (year) | 39.71 ± 9.59 | 37.12 ± 11.07 | 0.38 | | SBP (mmHg) | 130.02 ± 20.18 | 125.42 ± 18.09 | 0.27 | | DBP (mmHg) | 85.03 ± 10.40 | | 0.19 | | Hemoglobin (g/dL) | 119.00 ± 21.68 | 128.79 ± 12.45 | 0.03 | | Proteinuria (g/24 h) | 2.4 (1.4~4.0) | 2.6 (1.7~3.1) | 0.56 | | sAlb (g/L) | 36.1 ± 6.2 | 38.9 ± 3.9 | 0.34 | | Cholesterol (mmol/L) | 5.78 ± 1.36 | 5.90 ± 1.19 | 0.89 | | Triglyceride (mmol/L) | 2.49 ± 0.70 | 2.78 ± 0.58 | 0.08 | | Scr (μmol/L) | 97.50 (71.20–111.80) | 83.10 (71.00–109.70) | 0.03 | | eGFR (mL/min) | 71.49 ± 5.11 | 82.65 ± 7.89 | 0.04 | | sIgA (g/L) | 3.2 ± 0.7 | | 0.28 | | Hs-CRP (mg/L) | 4.76 ± 1.01 | | 0.30 | | sIL-18 at baseline (pg/mL) | 364.45 ± 40.25 | 353.67 ± 16.36 | 0.02 | | sIL-18 after treatment (pg/mL) | 132.44 ± 32.40 | 99.41 ± 24.14 | 0.04 | | GSS | 0.28 (0.09–0.50) | 0.25 (0.08–0.43) | 0.78 | | TID | 4.00 (3.00–6.00) | 2.50 (2.00–4.00) | 0.03 | | Steroid responsiveness (n) | 19 | 32 | 0.06 |
|
|
