Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst

<table>Peritonitis is limited by SOD3. Ade-SOD3-treated mice had less peritoneal infiltrating cells after peritonitis induction with proteose peptone and IL-1<i>β</i> than Ade-LacZ-treated control mice (a) (<svg height="10.925" id="M8" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.65)"><use xlink:href="#x1D45B"></use></g><g transform="matrix(.017,-0,0,-.017,13.305,10.65)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,28.008,10.65)"><use xlink:href="#x35"></use></g>
</svg>). The reduction in cell number was mainly due to diminished peritoneal macrophage population (b) (Nf = neutrophil, Mf = macrophage, Lc = lymphocyte).</table>

Mediators of Inflammation

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Figure 4

Figure 4: Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst 