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Mediators of Inflammation
Volume 2012 (2012), Article ID 730469, 9 pages
Research Article

Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst

1Medicity Research Laboratory, University of Turku, Tykistökatu 6 A, 20520 Turku, Finland
2Turku Doctoral Programme of Biomedical Sciences, Kiinamyllynkatu 13, 20520 Turku, Finland
3Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
4Redoxis AB, Sahlgrenska Science Park, Medicinaregatan 8A, 413 46 Göteborg, Sweden
5Fondazione SDN, 80143 Naples, Italy

Received 14 September 2011; Revised 21 November 2011; Accepted 12 December 2011

Academic Editor: Christoph Aufricht

Copyright © 2012 Tiina Kelkka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary figure 1. The expression of SOD3 did not affect arthritis severity in the control paws. Arthritis severity in the non-treated control paws was not affected in either wild type (A) or Ncf1*/* mice (B). Sum score of all three non-treated paws is presented for both genotypes. In wild type mice (Ade-SOD3 n=6, Ade-lacZ n=7) and in Ncf1*/* mice (Ade-SOD3 n=22, Ade-lacZ n=23).

  1. Supplementary Material