CXCL1-Triggered Interaction of LFA1 and ICAM1 Control Glucose-Induced Leukocyte Recruitment during Inflammation In Vivo

Table 1

Hemodynamic and microvascular parameters of cremaster muscle venules before and after stimulation with glucose in the trauma model. Vessel diameter, centerline velocity, and wall shear rate are displayed before and after the intravenous administration of different doses of glucose and compared to the application of the equivalent volume of normal saline and the biologically inactive L-glucose. Experiments are presented as mean ± SEM; n.s.: not significant, stating no differences of hemodynamic parameters among the different doses and during the time course after glucose/saline injection.

	Mice	Venules	Diameter	Centerline velocity	Wall shear rate	Systemic leukocyte counts
	𝑁	𝑛	(𝜇m)	(𝜇m/s)	(s^−1)	(/𝜇L)
Saline injection
Pre-saline	4	18	28 ± 1	2200 ± 100	1900 ± 100	6300 ± 300
5′ after saline	4	18	28 ± 1	2300 ± 100	1900 ± 100	6200 ± 200
15′ after saline	4	18	28 ± 1	2400 ± 100	2000 ± 100	5900 ± 400
			n.s.	n.s.	n.s.	n.s.
Injection of 0,25 g/kg glucose
Pre-glucose	3	12	30 ± 1	2400 ± 100	2400 ± 100	4300 ± 200
5′ after glucose	3	12	30 ± 1	2400 ± 100	2000 ± 100	4300 ± 200
15′ after glucose	3	12	30 ± 1	2400 ± 100	2000 ± 100	4400 ± 200
			n.s.	n.s.	n.s.	n.s.
Injection of 0,5 g/kg L-glucose
Pre-glucose	5	26	29 ± 1	2300 ± 100	1900 ± 100	4900 ± 200
5′ after glucose	5	13	29 ± 1	2300 ± 100	1900 ± 100	4800 ± 200
15′ after glucose	5	18	29 ± 1	2300 ± 100	2000 ± 100	4900 ± 200
			n.s.	n.s.	n.s.	n.s.
Injection of 0,5 g/kg glucose
Pre-glucose	16	64	28 ± 1	2200 ± 100	1900 ± 100	6500 ± 100
5′ after glucose	16	64	28 ± 1	2300 ± 100	2000 ± 200	6200 ± 200
15′ after glucose	16	64	28 ± 1	2400 ± 100	2000 ± 100	6400 ± 100
			n.s.	n.s.	n.s.	n.s.
Injection of 1 g/kg glucose
Pre-glucose	4	10	27 ± 1	2300 ± 100	2200 ± 100	6300 ± 200
5′ after glucose	4	10	27 ± 1	2400 ± 100	2100 ± 100	6300 ± 200
15′ after glucose	4	10	27 ± 1	2300 ± 100	2100 ± 200	6300 ± 200
			n.s.	n.s.	n.s.	n.s.