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Mediators of Inflammation
Volume 2012, Article ID 874149, 6 pages
Research Article

Microalbuminuria and sRAGE in High-Risk Hypertensive Patients Treated with Nifedipine/Telmisartan Combination Treatment: A Substudy of TALENT

1Interdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, Italy
2Department of Cardiology, Istituto di Cura Città di Pavia, University Hospital, 27100 Pavia, Italy
3Department of Nephrology, IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy
4Scientific Relations, Medical Department, Bayer S.p.A-Pharmaceutical, 20156 Milan, Italy
5Department of Clinical Medicine and Prevention, University of Milano-Bicocca, 20126 Milan, Italy

Received 14 September 2011; Revised 15 November 2011; Accepted 24 November 2011

Academic Editor: Fabrizio Montecucco

Copyright © 2012 Colomba Falcone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some antihypertensive drugs have also renoprotective and anti-inflammatory properties that go beyond their effect on blood pressure. It has been suggested that microalbuminuria and glomerular filtration rate (GFR) are associated with circulating levels of the soluble form of the receptor, sRAGE (soluble receptor for advanced glycation ends-products). In the present analysis, we used data from the TALENT study to evaluate soluble receptor for advanced glycation end-products (sRAGE) plasma levels in patients with hypertension and high-cardiovascular risk-treated nifedipine and telmisartan in combination. Treatment with nifedipine-telmisartan significantly decreased mean systolic and diastolic ambulatory blood pressure and resulted in a significant increase in sRAGE plasma concentrations after 24 weeks of therapy. We concluded that in hypertensive patients with early-stage renal disease, sRAGE concentrations are not influenced by either microalbuminuria or GFR. Long-term treatment with a combination of nifedipine-telmisartan may have a beneficial effect increasing sRAGE plasma levels, thus exerting an atheroprotective and anti-inflammatory activity.