Review Article
Peripheral Mechanisms of Dental Pain: The Role of Substance P
Table 1
Key effects of substance P in dental pulp.
| Healthy tissues | Maintenance of tissue homeostasis [6, 27, 28] |
| Inflamed tissues | Vasodilatatory response [6, 7] | Histamine release [29] | Increase in blood flow [29] | Increase in vascular permeability [29] | Increase in blood pressure [29] | Synthesis of proinflammatory cytokines [30, 31] | Chemotaxis of inflammatory cells [30] | Sensitisation of nociceptors [7] |
|
|