Review Article

Peripheral Mechanisms of Dental Pain: The Role of Substance P

Table 1

Key effects of substance P in dental pulp.

Healthy tissues
 Maintenance of tissue homeostasis [6, 27, 28]

Inflamed tissues
 Vasodilatatory response [6, 7]
 Histamine release [29]
 Increase in blood flow [29]
 Increase in vascular permeability [29]
 Increase in blood pressure [29]
 Synthesis of proinflammatory cytokines [30, 31]
 Chemotaxis of inflammatory cells [30]
 Sensitisation of nociceptors [7]