Review Article

TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion

Figure 1

Brain injury caused by cerebral ischemia/reperfusion is a complicated pathophysiological course, in which TLR2 and TLR4 are thought to play an important role. TLR2 and TLR4 play crucial roles in modulating inflammatory response caused by cerebral ischemia and reperfusion via linking to their endogenous ligands and then recruit specific adaptors within cells. TLRs signal activates the transcription factors and generates cytokines and chemokines via intracellular pathways.
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