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Mediators of Inflammation
Volume 2013, Article ID 137579, 13 pages
http://dx.doi.org/10.1155/2013/137579
Review Article

Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

1Programa de Pós-Graduação em Nutrição, Disciplina de Fisiologia da Nutrição, EPM, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu, 862 Edifício de Ciências Biomédicas, 2 andar, Vila Clementino, 04023-060 São Paulo, SP, Brazil
2Departamento de Biociências, UNIFESP, Campus Baixada Santista, 11060-001 Santos, SP, Brazil

Received 25 October 2012; Revised 19 December 2012; Accepted 19 December 2012

Academic Editor: Fábio Santos Lira

Copyright © 2013 Débora Estadella et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [74 citations]

The following is the list of published articles that have cited the current article.

  • Eibhlís M. O’Connor, “The role of gut microbiota in nutritional status,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 16, no. 5, pp. 509–516, 2013. View at Publisher · View at Google Scholar
  • Mei-chin Mong, Te-chun Hsia, and Mei-chin Yin, “Dietary Trans Fats Enhance Doxorubicin-Induced Cardiotoxicity in Mice,” Journal of Food Science, 2013. View at Publisher · View at Google Scholar
  • Veronika Zámbó, Laura Simon-Szabó, Péter Szelényi, Éva Kereszturi, Gábor Bánhegyi, and Miklós Csala, “Lipotoxicity in the liver,” World Journal of Hepatology, vol. 5, no. 10, pp. 550–557, 2013. View at Publisher · View at Google Scholar
  • Valeria Gasperi, Isabella Savini, Maria Valeria Catani, Daniela Evangelista, and Luciana Avigliano, “Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State,” International Journal Of Molecular Sciences, vol. 14, no. 5, pp. 10497–10538, 2013. View at Publisher · View at Google Scholar
  • Bruno dos Santos, Debora Estadella, Ana Cláudia Losinskas Hachul, Marcos Hiromu Okuda, Mayara Franzoi Moreno, Lila Missae Oyama, Eliane Beraldi Ribeiro, and Claudia Maria da Penha Oller do Nascimento, “Effects of a Diet Enriched with Polyunsaturated, Saturated, or Trans Fatty Acids on Cytokine Content in the Liver, White Adipose Tissue, and Skeletal Muscle of Adult Mice,” Mediators of Inflammation, vol. 2013, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  • Susana Rovira-Llopis, Antonio Hernández-Mijares, Milagros Rocha, and Victor M Victor, “The role of reactive oxygen species in obesity therapeutics,” Expert Review of Endocrinology & Metabolism, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  • Olga Raz, Arie Steinvil, Tovit Rosenzweig, Shlomo Berliner, Itzhak Shapira, and Mona Boaz, “An eight-week High complex carbohydrate, energy restricted dietary intervention Is associated with weight loss and a reduction of inflammation markers,” Bioactive Carbohydrates and Dietary Fibre, 2014. View at Publisher · View at Google Scholar
  • Wafa Kharroubi, Madiha Dhibi, Manel Mekni, Zohra Haouas, Imed Chreif, Fadoua Neffati, Mohamed Hammami, and Rachid Sakly, “Sodium arsenate induce changes in fatty acids profiles and oxidative damage in kidney of rats,” Environmental Science and Pollution Research, 2014. View at Publisher · View at Google Scholar
  • Mayara Franzoi Moreno, Gabriel Inacio de Morais Honorato de Souza, Ana Claudia Losinskas Hachul, Bruno dos Santos, Marcos Hiromu Okuda, Nelson Inacio Pinto Neto, Valter Tadeu Boldarine, Elisa Esposito, Eliane Beraldi Ribeiro, Claudia Maria da Penha Oller do Nascimento, Aline de Piano Ganen, and Lila Missae Oyama, “Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet,” Nutrition & Metabolism, vol. 11, 2014. View at Publisher · View at Google Scholar
  • Jackie L. Boucher, Alison B. Evert, and Marion J. Franz, “Evidence-based diabetes nutrition therapy recommendations are effective: The key is individualization,” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. 7, pp. 65–72, 2014. View at Publisher · View at Google Scholar
  • Fernando Milanez Dias, Daniela Dimer Leffa, Francine Daumann, Scherolin de Oliveira Marques, Thais F. Luciano, Jonathan Correa Possato, Aline Alves de Santana, Rodrigo Xavier Neves, Jose Cesar Rosa, Lila Missae Oyama, Bruno Rodrigues, Vanessa Moraes de Andrade, Claudio Teodoro de Souza, and Fabio Santos de Lira, “Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet,” Lipids in Health and Disease, vol. 13, 2014. View at Publisher · View at Google Scholar
  • J.A. Paniagua, J.M. Escandell-Morales, D. Gil-Contreras, F.J. Berral de la Rosa, M. Romero-Jimenez, A. Gómez-Urbano, A. Sanchez-Lopez, E. Bellido, A. Poyato, B. Calatayud, and A.J. Vidal-Puig, “Central obesity and altered peripheral adipose tissue gene expression characterize the NAFLD patient with insulin resistance: Role of nutrition and insulin challenge,” Nutrition, vol. 30, no. 2, pp. 177–185, 2014. View at Publisher · View at Google Scholar
  • Mohamad Hafizi Abu Bakar, Cheng Kian Kai, Wan Najihah Wan Hassan, Mohamad Roji Sarmidi, Harisun Yaakob, and Hasniza Zaman Huri, “Mitochondrial dysfunction as a central event for mechanisms underlying insulin resistance: the roles of long chain fatty acids,” Diabetes/Metabolism Research and Reviews, 2014. View at Publisher · View at Google Scholar
  • Maitane Ibarguren, David J. López, and Pablo V. Escribá, “The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health,” Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014. View at Publisher · View at Google Scholar
  • Anjum Khanam, and Kalpana Platel, “Bioaccessibility of selenium, selenomethionine and selenocysteine from foods and influence of heat processing on the same,” Food Chemistry, 2015. View at Publisher · View at Google Scholar
  • Kenta Mori, Tatsuro Ishida, Tomoyuki Yasuda, Minoru Hasokawa, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Hideto Nakajima, Masakazu Shinohara, Toshiro Shinke, Yasuhiro Irino, Ryuji Toh, Kunihiro Nishimura, and Ken-ichi Hirata, “Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan,” Circulation Journal, vol. 79, no. 9, pp. 2017–U352, 2015. View at Publisher · View at Google Scholar
  • Marion J. Franz, Jackie L. Boucher, Stephanie Rutten-Ramos, and Jeffrey J. VanWormer, “Lifestyle Weight-Loss Intervention Outcomes in Overweight and Obese Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Clinical Trials,” Journal of the Academy of Nutrition and Dietetics, 2015. View at Publisher · View at Google Scholar
  • Deanna Minich, and Benjamin Brown, “Healing the Heart with Whole Foods and Food Bioactives,” Nutritional and Integrative Strategies in Cardiovascular Medicine, pp. 103–146, 2015. View at Publisher · View at Google Scholar
  • Meegun Hong, Seung Woo Kim, Sang Hak Han, Dong Joon Kim, Ki Tae Suk, Yeon Soo Kim, Myong Jo Kim, Moon Young Kim, Soon Koo Baik, and Young Lim Ham, “Probiotics (Lactobacillus rhamnosus R0011 and acidophilus R0052) Reduce the Expression of Toll-Like Receptor 4 in Mice with Alcoholic Liver Disease,” Plos One, vol. 10, no. 2, 2015. View at Publisher · View at Google Scholar
  • A. Mateu, I. De Dios, M. A. Manso, and L. Ramudo, “Unsaturated but not saturated fatty acids induce transcriptional regulation of CCL2 in pancreatic acini. A potential role in acute pancreatitis,” Biochimica Et Biophysica Acta-Molecular Basis Of Disease, vol. 1852, no. 12, pp. 2671–2677, 2015. View at Publisher · View at Google Scholar
  • Takayuki Ishida, Satoko Naoe, Masanori Nakakuki, Hiroyuki Kawano, and Kazunori Imada, “Eicosapentaenoic acid prevents saturated fatty acid-induced vascular endothelial dysfunction: Involvement of long-chain acyl-CoA synthetase,” Journal of Atherosclerosis and Thrombosis, vol. 22, no. 11, pp. 1172–1185, 2015. View at Publisher · View at Google Scholar
  • Chreif Imed, Sakly Rachid, Kharroubi Wafa, Dhibi Madiha, Gérard Lizard, and Hammami Mohamed, “Differential Alterations of Lipid Status and Lipid Metabolism, Induction of Oxidative Stress by Sodium Arsenate in Female Rat's Liver and Kidney,” Biomedical and Environmental Sciences, vol. 28, no. 11, pp. 829–833, 2015. View at Publisher · View at Google Scholar
  • Kharroubi Wafa, Dhibi Madiha, Chreif Imed, Gerard Lizard, Hammami Mohamed, and Sakly Rachid, “Differential Alterations of Lipid Status and Lipid Metabolism, Induction of Oxidative Stress by Sodium Arsenate in Female Rat's Liver and Kidney,” Biomedical And Environmental Sciences, vol. 28, no. 11, pp. 829–833, 2015. View at Publisher · View at Google Scholar
  • Y. Poorna Chandra Rao, and B. R. Lokesh, “Diet containing partially hydrogenated vegetable fat enhances the carrageenan induced paw inflammation but not oxidative stress markers in liver of ra,” Journal Of Food Science And Technology-Mysore, vol. 52, no. 10, pp. 6395–6404, 2015. View at Publisher · View at Google Scholar
  • A.P.S. Dornellas, R.L.H. Watanabe, G.D. Pimentel, V.T. Boldarine, C.M.O. Nascimento, L.M. Oyama, K. Ghebremeskel, Y. Wang, A.A. Bueno, and E.B. Ribeiro, “Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions,” Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2015. View at Publisher · View at Google Scholar
  • Thiago Belchior de Oliveira, Marcelo Macedo Rogero, and Maria Inés Genovese, “Poliphenolic-rich extracts from cocoa (Theobroma cacao L.) and cupuassu (Theobroma grandiflorum Willd. Ex Spreng. K. Shum) liquors: A comparison of metabolic effects in high-fat fed rats,” PharmaNutrition, 2015. View at Publisher · View at Google Scholar
  • Ema Kantorová, Ľubica Jesenská, Daniel Čierny, Kamil Zeleňák, Štefan Sivák, Matej Stančík, Peter Galajda, Vladimír Nosáľ, and Egon Kurča, “The Intricate Network of Adipokines and Stroke,” International Journal of Endocrinology, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Natalia Garay-Lugo, Aarón Domínguez-Lopez, Angel Miliar García, Eliud Aguilar Barrera, Modesto Gómez López, Alejandro Gómez Alcalá, Maria de los Angeles Martínez Godinez, and Eleazar Lara-Padilla, “ n-3 Fatty acids modulate the mRNA expression of the Nlrp3 inflammasome and Mtor in the liver of rats fed with high-fat or high-fat/fructose diets ,” Immunopharmacology and Immunotoxicology, vol. 38, no. 5, pp. 353–363, 2016. View at Publisher · View at Google Scholar
  • Qun Zhu, Jianjun Yang, Rongping Zhu, Xin Jiang, Wanlian Li, Songqing He, and Junfei Jin, “Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis,” Apoptosis, 2016. View at Publisher · View at Google Scholar
  • Sosuke Akagi, Nozomu Kono, Hiroyuki Ariyama, Hideo Shindou, Takao Shimizu, and Hiroyuki Arai, “Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids,” Faseb Journal, vol. 30, no. 5, pp. 2027–2039, 2016. View at Publisher · View at Google Scholar
  • Marion J. Franz, “Diabetes Nutrition Therapy: Effectiveness, Macronutrients, Eating Patterns and Weight Management,” American Journal of the Medical Sciences, vol. 351, no. 4, pp. 374–379, 2016. View at Publisher · View at Google Scholar
  • Marion J. Franz, “Nutrition Therapy for the Prevention and Treatment of Prediabetes and Diabetes,” Nutrition in Lifestyle Medicine, pp. 151–171, 2016. View at Publisher · View at Google Scholar
  • Hu Xiao, Naoki Tanaka, Guo Ran, Lu Yu, Takero Nakajima, Frank J. Gonzalez, and Toshifumi Aoyama, “PPARα protects against trans-fatty acid-containing diet-induced steatohepatitis,” The Journal of Nutritional Biochemistry, 2016. View at Publisher · View at Google Scholar
  • Rafael Longhi, Roberto Farina Almeida, Letiane Machado, Maria Marta Medeiros Frescura Duarte, Débora Guerini Souza, Priscila Machado, Adriano Martimbianco de Assis, André Quincozes-Santos, and Diogo Onofre Souza, “Effect of a trans fatty acid-enriched diet on biochemical and inflammatory parameters in Wistar rats,” European Journal of Nutrition, 2016. View at Publisher · View at Google Scholar
  • Y. Poorna Chandra Rao, and B. R. Lokesh, “Down-regulation of NF-κB expression by n-3 fatty acid-rich linseed oil is modulated by PPARγ activation, eicosanoid cascade and secretion of cytokines by macrophages in rats fed partially hydrogenated vegetable fat,” European Journal of Nutrition, vol. 56, no. 3, pp. 1135–1147, 2016. View at Publisher · View at Google Scholar
  • Giovanni Annuzzi, Ettore Griffo, Giuseppina Costabile, and Lutgarda Bozzetto, “Dietary Fatty Acids and C-Reactive Protein,” Molecular Nutrition and Diabetes, pp. 221–236, 2016. View at Publisher · View at Google Scholar
  • Fernanda Michielin Busnello, Zilda Elisabeth de Albuquerque Santos, and Bruna Pontin, “Lipids and Metabolic Syndrome,” Handbook of Lipids in Human Function, pp. 543–556, 2016. View at Publisher · View at Google Scholar
  • Sartika, Achmad, Triyanti, and Rustika, “Effect of trans fatty acid on glucose level and pancreatic β cell in rats,” Pakistan Journal of Nutrition, vol. 15, no. 8, pp. 760–762, 2016. View at Publisher · View at Google Scholar
  • Yuan E Zhou, Maciej S Buchowski, Jianguo Liu, David G Schlundt, Flora A M Ukoli, William J Blot, and Margaret K Hargreaves, “Plasma Lycopene Is Associated with Pizza and Pasta Consumption in Middle-Aged and Older African American and White Adults in the Southeastern USA in a Cross-Sectional Study.,” PloS one, vol. 11, no. 9, 2016. View at Publisher · View at Google Scholar
  • Rosamaria Lappano, Anna Sebastiani, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Giulia Raffaella Galli, Rosita Curcio, Roberta Malaguarnera, Antonino Belfiore, Anna Rita Cappello, and Marcello Maggiolini, “The lauric acid-activated signaling prompts apoptosis in cancer cells,” Cell Death Discovery, vol. 3, pp. 17063, 2017. View at Publisher · View at Google Scholar
  • Yoshinori Nagasawa, Toshiro Shinke, Ryuji Toh, Tatsuro Ishida, Hiromasa Otake, Tomofumi Takaya, Daisuke Sugiyama, Takayosi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Natsuko Tahara, Yuto Shinkura, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Yuichiro Nagano, Hiroyuki Yamamoto, Kenichi Yanaka, Yoshiro Tsukiyama, and Ken-ichi Hirata, “The impact of serum trans fatty acids concentration on plaque vulnerability in patients with coronary artery disease: Assessment via optical coherence tomography,” Atherosclerosis, 2017. View at Publisher · View at Google Scholar
  • Su-Ying Wen, Bharath Kumar Velmurugan, Cecilia Hsuan Day, Chia-Yao Shen, Li-Chin Chun, Yi-Chieh Tsai, Yueh-Min Lin, Ray-Jade Chen, Chia-Hua Kuo, and Chih-Yang Huang, “High density lipoprotein (HDL) reverses palmitic acid induced energy metabolism imbalance by switching CD36 and GLUT4 signaling pathways in cardiomyocyte,” Journal of Cellular Physiology, 2017. View at Publisher · View at Google Scholar
  • Isabella Reccia, Jayant Kumar, Cherif Akladios, Francesco Virdis, Madhava Pai, Nagy Habib, and Duncan Spalding, “Non-alcoholic Fatty Liver Disease: a sign of systemic disease,” Metabolism, 2017. View at Publisher · View at Google Scholar
  • Yusuke Hirata, Miki Takahashi, Yuki Kudoh, Kuniyuki Kano, Hiroki Kawana, Kumiko Makide, Yasuharu Shinoda, Yasushi Yabuki, Kohji Fukunaga, Junken Aoki, Takuya Noguchi, and Atsushi Matsuzawa, “ trans -Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway ,” Journal of Biological Chemistry, vol. 292, no. 20, pp. 8174–8185, 2017. View at Publisher · View at Google Scholar
  • Sherazed Hamza-Reguig, Nabila Boukhari Benahmed Daidj, Sabrine Louala, Ahmed Boualga, and Myriem Lamri-Senhadji, “Effect of replacing sardine oil with margarine on dyslipidemia, dysglycemia and redox status of adipose tissue in high-fat diet-induced obesity in Wistar rats,” Nutrition & Food Science, vol. 47, no. 1, pp. 2–17, 2017. View at Publisher · View at Google Scholar
  • Weilong Zheng, Xudong Wang, Wenjing Cao, Bowen Yang, Ying Mu, Yuesheng Dong, and Zhilong Xiu, “E-configuration structures of EPA and DHA derived from Euphausia superba and their significant inhibitive effects on growth of human cancer cell lines in vitro,” Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol. 117, pp. 47–53, 2017. View at Publisher · View at Google Scholar
  • Wanwanut Limpimwong, Thanutchaporn Kumrungsee, Norihisa Kato, Noriyuki Yanaka, and Masubon Thongngam, “Rice bran wax oleogel: A potential margarine replacement and its digestibility effect in rats fed a high-fat diet,” Journal of Functional Foods, vol. 39, pp. 250–256, 2017. View at Publisher · View at Google Scholar
  • Chengting Zhang, Yanli Ma, Yingxin Zhao, Yaoqin Hong, Shengbao Cai, and Mingjie Pang, “ Phenolic composition, antioxidant and pancreatic lipase inhibitory activities of Chinese sumac ( Rhus chinensis Mill.) fruits extracted by different solvents and interaction between myricetin-3- O -rhamnoside and quercetin-3- O -rhamnoside ,” International Journal of Food Science & Technology, 2017. View at Publisher · View at Google Scholar
  • Nannan Wang, Jie Guo, Fuding Liu, Mingxia Wang, Chuntao Li, Lihong Jia, Lingling Zhai, Wei Wei, and Yinglong Bai, “Depot-specific inflammation with decreased expression of ATM2 in white adipose tissues induced by high-margarine/lard intake,” Plos One, vol. 12, no. 11, pp. e0188007, 2017. View at Publisher · View at Google Scholar
  • Hwi Won Seo, Jae Hyun Suh, Seung-Ho So, Jong-Soo Kyung, Yong-Soon Kim, and Chang-Kyun Han, “Subacute oral toxicity and bacterial mutagenicity study of Korean Red Ginseng oil,” Journal of Ginseng Research, 2017. View at Publisher · View at Google Scholar
  • David Porras, Esther Nistal, Susana Martínez-Flórez, Sandra Pisonero-Vaquero, José Luis Olcoz, Ramiro Jover, Javier González-Gallego, María Victoria García-Mediavilla, and Sonia Sánchez-Campos, “Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation,” Free Radical Biology and Medicine, vol. 102, pp. 188–202, 2017. View at Publisher · View at Google Scholar
  • Michelle McMacken, and Sapana Shah, “A plant-based diet for the prevention and treatment of type 2 diabetes,” Journal of Geriatric Cardiology, vol. 14, no. 5, pp. 342–354, 2017. View at Publisher · View at Google Scholar
  • Adolfo Toledano, Arantxa Rodriguez-Casado, and Adolfo Toledano-Díaz, “Defective insulin signalling, mediated by inflammation, connects obesity to Alzheimer disease; relevant pharmacological therapies and preventive dietary interventions,” Current Alzheimer Research, vol. 14, no. 8, pp. 894–911, 2017. View at Publisher · View at Google Scholar
  • Po-Jung Tsai, Mei-Ling Chang, Ching-Mei Hsin, Chung-Chieh Chuang, Lu-Te Chuang, and Wen-Huey Wu, “ Antilipotoxicity Activity of Osmanthus fragrans and Chrysanthemum morifolium Flower Extracts in Hepatocytes and Renal Glomerular Mesangial Cells ,” Mediators of Inflammation, vol. 2017, pp. 1–12, 2017. View at Publisher · View at Google Scholar
  • Ana Carolina Momentti, Débora Estadella, and Luciana Pellegrini Pisani, “Role of vitamin D in pregnancy and Toll-like receptor pathway,” Steroids, vol. 137, pp. 22–29, 2018. View at Publisher · View at Google Scholar
  • Hossein Montakhab-Yeganeh, Hossein Babaahmadi-Rezaei, and Mahmood Doosti, “Effect of elaidic acid on ABCA1 expression in RAW 264.7 cells. is it through PPAR−γ?,” EXCLI Journal, vol. 17, pp. 864–870, 2018. View at Publisher · View at Google Scholar
  • Leandra Koletzko, Abdo Mahli, and Claus Hellerbrand, “Development of an in vitro model to study hepatitis C virus effects on hepatocellular lipotoxicity and lipid metabolism,” Pathology - Research and Practice, 2018. View at Publisher · View at Google Scholar
  • Uzma Zafar, Saba Khaliq, Hafiz Usman Ahmad, Sobia Manzoor, and Khalid P. Lone, “Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links,” Hormones, 2018. View at Publisher · View at Google Scholar
  • Mohsen Mazidi, Niki Katsiki, Dimitri P. Mikhailidis, and Maciej Banach, “Link between plasma trans- fatty acid and fatty liver is moderated by adiposity,” International Journal of Cardiology, 2018. View at Publisher · View at Google Scholar
  • Qianwen Ding, Zhen Zhang, Chao Ran, Suxu He, Yalin Yang, Zhenyu Du, Jinxiong Zhang, and Zhigang Zhou, “The Hepatotoxicity of Palmitic Acid in Zebrafish Involves the Intestinal Microbiota,” The Journal of Nutrition, 2018. View at Publisher · View at Google Scholar
  • Monika Sobol, Stanisława Raj, and Grzegorz Skiba, “Inulin supplementation reduces the negative effect of a high-fat diet rich in SFA on bone health of growing pigs,” British Journal of Nutrition, vol. 119, no. 10, pp. 1111–1118, 2018. View at Publisher · View at Google Scholar
  • Seon-Heui Cha, Yongha Hwang, Kil-Nam Kim, and Hee-Sook Jun, “Palmitate induces nitric oxide production and inflammatory cytokine expression in zebrafish,” Fish & Shellfish Immunology, 2018. View at Publisher · View at Google Scholar
  • Sun Ryoung Choi, Ji Hee Lim, Min Young Kim, Eun Nim Kim, Yaeni Kim, Beom Soon Choi, Yong-Soo Kim, Hye Won Kim, Kyung-Min Lim, Min Jeong Kim, and Cheol Whee Park, “Adiponectin Receptor Agonist AdipoRon Decreased Ceramide, and Lipotoxicity, and Ameliorated Diabetic Nephropathy,” Metabolism, 2018. View at Publisher · View at Google Scholar
  • Gurdeep Marwarha, Jared Schommer, Jonah Lund, Trevor Schommer, and Othman Ghribi, “Palmitate-induced C/EBP homologous protein activation leads to NF-κB-mediated increase in BACE1 activity and amyloid beta genesis,” Journal of Neurochemistry, 2018. View at Publisher · View at Google Scholar
  • Yeh-Peng Chen, Wei-Wen Kuo, Rathinasamy Baskaran, Cecilia-Hsuan Day, Ray-Jade Chen, Su-Ying Wen, Tsung-Jung Ho, Viswanadha Vijaya Padma, Chia-Hua Kuo, and Chih-Yang Huang, “Acute hypoxic preconditioning prevents palmitic acid-induced cardiomyocyte apoptosis via switching metabolic GLUT4-glucose pathway back to CD36-fatty acid dependent,” Journal of Cellular Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Cassiano Felippe Gonçalves-de-Albuquerque, Marcos Roberto Colombo Barnese, Mariana Alves Soares, Mauro Velho Castro-Faria, Adriana Ribeiro Silva, Hugo Caire de Castro-Faria-Neto, Patrícia Burth, and Mauricio Younes-Ibrahim, “Serum albumin saturation test based on non-esterified fatty acids imbalance for clinical employment,” Clinica Chimica Acta, vol. 495, pp. 422–428, 2019. View at Publisher · View at Google Scholar
  • Ismail Cimen, Zehra Yildirim, Asli Ekin Dogan, Asli Dilber Yildirim, Özlem Tufanlı, Umut Inci Onat, UyenThao Nguyen, Steven M. Watkins, Christian Weber, and Ebru Erbay, “Double bond configuration of palmitoleate is critical for atheroprotection,” Molecular Metabolism, 2019. View at Publisher · View at Google Scholar
  • Aline Boveto Santamarina, Giovana Jamar, Laís Vales Mennitti, Helena de Cássia Cesar, José Ronnie Vasconcelos, Lila Missae Oyama, Veridiana Vera de Rosso, and Luciana Pellegrini Pisani, “Obesity-related inflammatory modulation by juçara berry (Euterpe edulis Mart.) supplementation in Brazilian adults: a double-blind randomized controlled trial,” European Journal of Nutrition, 2019. View at Publisher · View at Google Scholar
  • Aline Boveto Santamarina, Giovana Jamar, Laís Vales Mennitti, Daniel Araki Ribeiro, Caroline Margonato Cardoso, Veridiana Vera de Rosso, Lila Missae Oyama, and Luciana Pellegrini Pisani, “Polyphenols-Rich Fruit (Euterpe edulis Mart.) Prevents Peripheral Inflammatory Pathway Activation by the Short-Term High-Fat Diet,” Molecules, vol. 24, no. 9, pp. 1655, 2019. View at Publisher · View at Google Scholar
  • Megu Y Baden, Ambika Satija, Frank B Hu, and Tianyi Huang, “Change in Plant-Based Diet Quality Is Associated with Changes in Plasma Adiposity-Associated Biomarker Concentrations in Women,” The Journal of Nutrition, 2019. View at Publisher · View at Google Scholar
  • Yoon Hee Kim, Kyung Won Kim, So-Yeon Lee, Kyeong Ok Koo, Sung-Ok Kwon, Ju-Hee Seo, Dong In Suh, Youn Ho Shin, Kangmo Ahn, Se-Young Oh, Sooyoung Lee, Myung Hyun Sohn, and Soo-Jong Hong, “Maternal Perinatal Dietary Patterns Affect Food Allergy Development in Susceptible Infants,” The Journal of Allergy and Clinical Immunology: In Practice, 2019. View at Publisher · View at Google Scholar
  • Shenzong Rao, Jingsong Huang, Zhijun Shen, Changgang Xiang, Min Zhang, and Xueliang Lu, “Inhibition of TREM-1 attenuates inflammation and lipid accumulation in diet-induced nonalcoholic fatty liver disease,” Journal of Cellular Biochemistry, 2019. View at Publisher · View at Google Scholar
  • Terry L. Wahls, Catherine A. Chenard, and Linda G. Snetselaar, “Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic,” Nutrients, vol. 11, no. 2, pp. 352, 2019. View at Publisher · View at Google Scholar
  • Cassiano Felippe Gonçalves-de-Albuquerque, Marcos Roberto Colombo Barnese, Mariana Alves Soares, Mauro Velho Castro Faria, Adriana Ribeiro Silva, Hugo Caire Castro Faria Neto, Patrícia Burth, and Mauricio Younes-Ibrahim, “Serum albumin-fatty acid saturation test,” MethodsX, vol. 6, pp. 1871–1875, 2019. View at Publisher · View at Google Scholar