Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells: A Nondirected Metabolomic Study

Figure 4

Variations in phospholipid metabolites in HUVEC cell homogenates (𝑛=3, for each experiment). Endothelial cells were incubated over 24 h with 50 mg/L isolated human LDL (L); 50 mg/L oxidized LDL (O); 50 mg/L oxidized LDL + 40 mg/L HDL from wild type mice (OH); 50 mg/L oxidized LDL + 40 mg/L HDL from PON1^(−/−) mice (KO); or with serum-free media as controls (C). ^∗𝑃<0.05 with respect to L; ^†𝑃<0.05 with respect to O; ^‡𝑃<0.05 with respect to OH.