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Mediators of Inflammation
Volume 2013, Article ID 171437, 18 pages
Research Article

TNF-α and IFN-s-Dependent Muscle Decay Is Linked to NF- B- and STAT-1α-Stimulated Atrogin1 and MuRF1 Genes in C2C12 Myotubes

1Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences—SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland
2Electron Microscopy Platform, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland

Received 4 July 2013; Revised 9 September 2013; Accepted 4 October 2013

Academic Editor: Elaine Hatanaka

Copyright © 2013 Barbara Pijet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary material 1: Dose-response and time-dependent curves showing long term effects of TNF-α, IFNα, IFNγ (10 ng/mL each) on cell viability.

Supplementary material 2: Immunofluorescent detection of NF-κB location in 3-day old C2C12 myotubes using confocal microscopy.

Supplementary material 3: Myotube formation from C2C12 myoblasts.

  1. Supplementary Material 1
  2. Supplementary Material 2
  3. Supplementary Material 3